23068-36-2

Basic information

• Product Name: N-(2,3-dichlorophenyl)acetamide
• Synonyms: N-(2,3-dichlorophenyl)acetamide
• CAS NO: 23068-36-2
• Molecular Formula: C₈H₇Cl₂NO
• Molecular Weight: 204.06
• Mol File: 23068-36-2.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 351.7°C at 760 mmHg
• Flash Point: 166.5°C
• Appearance: /
• Density: 1.393g/cm³
• Vapor Pressure: 4.04E-05mmHg at 25°C
• Refractive Index: 1.603
• CAS DataBase Reference: N-(2,3-dichlorophenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2,3-dichlorophenyl)acetamide(23068-36-2)
• EPA Substance Registry System: N-(2,3-dichlorophenyl)acetamide(23068-36-2)

Safety Data

• Hazardous Substances Data: 23068-36-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H7Cl2NO/c1-5(12)11-7-4-2-3-6(9)8(7)10/h2-4H,1H3,(H,11,12)

Upstream product

• 608-27-5 2,3-dichloroaniline 
• 75-36-5 acetyl chloride 
• 3209-22-1 1,2-Dichloro-3-nitrobenzene 
• 108-24-7 acetic anhydride 
• 507-09-5 tiolacetic acid 

Downstream Products

• 65078-77-5 2,3-dichloro-6-nitroaniline 
• 69951-03-7 2,3-dichloro-4-nitroaniline 
• 65078-76-4 2,3-dichloro-6-nitroacetanilide 
• 261764-91-4 2,3-dichloro-4-nitroacetanilide 
• 1668-01-5 3,4-dichloro-1,2-phenylenediamine 
• 4146-25-2 7-chloro-2-methylbenzo[d]thiazole 
• 261764-92-5 2-chloro-4-nitro-1,3-benzenediammine 
• 261764-96-9 6,7-diaminoquinoline 
• 269-08-9 1H-imidazo[4,5-g]quinoline 
• 193090-61-8 C₇H₄Cl₂N₂ 
• 113571-16-7 4-Bromo-2,3-dichloroacetanilide 
• 65183-01-9 N-(2,3-dichlorophenyl)methanethioamide 

Relevant articles and documents

Design, synthesis, and preliminary in vitro and in silico antiviral activity of [4,7]phenantrolines and 1-oxo-1,4-dihydro-[4,7]phenantrolines against single-stranded positive-sense RNA genome viruses

Following the antiviral screening of a wide series of new angular and linear N-tricyclic systems both in silico and in vitro, the [4,7]phenantroline nucleus emerged as a new ring system endowed with activity against viruses containing single-stranded, positive-sense RNA genomes (ssRNA+). Here, we report our new pathway to the synthesis of this nucleus and of several related derivatives, as well as the results of both cell-based antiviral assays and molecular dynamics simulations. In the antiviral screening, several compounds (9 and 16-20) showed to be fairly active against BVDV, CVB-2, and Polio 1 (EC50, 6-25 μM). According to molecular dynamics simulations, compounds (15) and (17) emerged for its potency against the HCV NS5B, with a calculated IC50 of 11-12 μM.

Creating an antibacterial with in vivo efficacy: Synthesis and characterization of potent inhibitors of the bacterial cell division protein FTSZ with improved pharmaceutical properties

3-Methoxybenzamide (1) is a weak inhibitor of the essential bacterial cell division protein FtsZ. Alkyl derivatives of 1 are potent antistaphylococcal compounds with suboptimal drug-like properties. Exploration of the structure-activity relationships of analogues of these inhibitors led to the identification of potent antistaphylococcal compounds with improved pharmaceutical properties.

HIV reverse transcriptase inhibitors

Compounds having the structure: are HIV reverse transcriptase inhibitors, wherein A, X, Y, Z, R1 and R2 are defined herein. The compounds and their pharmaceutically acceptable salts are useful in the inhibition of HIV reverse transcriptase, the prophylaxis and treatment of infection by HIV and in the prophylaxis, delay in the onset, and treatment of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.