166809-58-1

Upstream product

• 39512-49-7 4-(4-chlorophenyl)-4-hydroxypiperidine 
• 166809-57-0 3-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]propionitrile 
• 75-09-2 dichloromethane 
• 193882-56-3 2-{3-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-propyl}-isoindole-1,3-dione 

Downstream Products

• 873107-36-9 C₂₂H₂₅ClN₄O₂ 
• 1021170-52-4 C₂₀H₂₄Cl₂N₂O₃S 
• 1021170-57-9 C₂₁H₂₇ClN₂O₃S 
• 1021170-61-5 C₂₁H₂₄ClF₃N₂O₄S 
• 1021170-70-6 C₂₀H₂₃Cl₃N₂O₃S 
• 1021170-62-6 C₂₁H₂₄ClF₃N₂O₄S 
• 1021170-48-8 C₂₄H₂₇ClN₂O₃S 
• 1021170-63-7 C₂₁H₂₇ClN₂O₄S 
• 1021170-58-0 C₂₁H₂₇ClN₂O₃S 
• 1021170-50-2 C₂₀H₂₅ClN₂O₃S 
• 1021170-76-2 C₂₀H₂₃Cl₂FN₂O₃S 
• 1021170-54-6 C₂₀H₂₄Cl₂N₂O₃S 
• 1021170-53-5 C₂₀H₂₄Cl₂N₂O₃S 
• 1021170-71-7 C₂₀H₂₃Cl₃N₂O₃S 

Relevant academic research and scientific papers

Identification of novel series of human CCR1 antagonists

A hit-to-lead optimization process was carried out on the high throughput screening hit compound 1 resulting in the identification of several potent and selective CCR1 receptor antagonists. Compound 37 shows the best overall profile with IC50 values of 100 nM in binding and functional assays.

CYCLIC AMIDE COMPOUNDS, PROCESS FOR THE PREPARATION OF THE SAME AND USES THEREOF

A compound of the formula: wherein R1 is a hydrocarbon group, R2 is a hydrocarbon group having 2 or more carbon atoms, where R1 and R2 may in combination form, together with an adjacent nitrogen atom, a ring optionally having a substituent or substituents, R3 is a hydrocarbon group optionally having a substituent or substituents or a heterocyclic group optionally having a substituent or substituents, R4 is a hydrogen atom, a hydrocarbon group, a heterocyclic group and the like, E is a divalent chain hydrocarbon group and the like, G is CO or SO2, J is a nitrogen atom, a methine group and the like, and Q and R are each a divalent chain C1-3 hydrocarbon group and the like, and a salt thereof show a superior CCR5 antagonistic activity and are useful as agents for the prophylaxis or treatment of HIV infection of human peripheral blood mononuclear cells, particularly AIDS.

Synthesis and pharmacological activity of 2-(substituted phenyl)-3{2 or 3-[(4-substituted phenyl-4-hydroxy)piperidino]ethyl or propyl}-1,3- thiazolidin-4-ones

A series of aryl-hydroxy-piperidinoalkyl-thiazolidinones was synthesized and evaluated to inhibit castor oil-induced diarrhea in mice. The dose dependent antidiarrheal activity of the most active compound 2-(p- nitrophenyl)-3-[2-[(4-(p-chlorophenyl)-4-hydroxy)piperidino]ethyl]-1,3- thiazolidin-4-one (6) was counteracted by naloxone, resulting comparable with that of loperamide, a μ opiate agonist.