193882-56-3

Basic information

• Product Name: 1H-Isoindole-1,3(2H)-dione, 2-[3-[4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl]propyl]-
• CAS NO: 193882-56-3
• Molecular Formula: C22H23ClN2O3
• Molecular Weight: 398.889
• Mol File: 193882-56-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1H-Isoindole-1,3(2H)-dione, 2-[3-[4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl]propyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Isoindole-1,3(2H)-dione, 2-[3-[4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl]propyl]-(193882-56-3)
• EPA Substance Registry System: 1H-Isoindole-1,3(2H)-dione, 2-[3-[4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl]propyl]-(193882-56-3)

Safety Data

• Hazardous Substances Data: 193882-56-3(Hazardous Substances Data)

Upstream product

• 5460-29-7 2-(3-bromopropyl)isoindole-1,3-dione 
• 39512-49-7 4-(4-chlorophenyl)-4-hydroxypiperidine 

Downstream Products

• 182188-92-7 3-{3-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-propyl}-2-p-tolyl-thiazolidin-4-one 
• 166809-58-1 1-(3-Aminopropyl)-4-(4-chlorophenyl)-4-hydroxypiperidine 

Relevant articles and documents

Identification of novel series of human CCR1 antagonists

A hit-to-lead optimization process was carried out on the high throughput screening hit compound 1 resulting in the identification of several potent and selective CCR1 receptor antagonists. Compound 37 shows the best overall profile with IC50 values of 100 nM in binding and functional assays.

Synthesis and pharmacological activity of 2-(substituted phenyl)-3{2 or 3-[(4-substituted phenyl-4-hydroxy)piperidino]ethyl or propyl}-1,3- thiazolidin-4-ones

A series of aryl-hydroxy-piperidinoalkyl-thiazolidinones was synthesized and evaluated to inhibit castor oil-induced diarrhea in mice. The dose dependent antidiarrheal activity of the most active compound 2-(p- nitrophenyl)-3-[2-[(4-(p-chlorophenyl)-4-hydroxy)piperidino]ethyl]-1,3- thiazolidin-4-one (6) was counteracted by naloxone, resulting comparable with that of loperamide, a μ opiate agonist.