16713-15-8

Basic information

• Product Name: N,N-DIETHYL-1,4-PHENYLENEDIAMINE DIHYDROCHLORIDE
• Synonyms: 4-benzenediamine,n,n-diethyl-hydrochloride;4-AMINO-N,N-DIETHYLANILINE DIHYDROCHLORIDE;N,N-DIETHYL-P-PHENYLENEDIAMINE DIHYDROCHLORIDE;N,N-DIETHYL-1,4-PHENYLENEDIAMINE DIHYDROCHLORIDE;4-amino-N,N-diethylaniline hydrochloride;N,N-Diethyl-1,4-phenylenediamine2HCl;N,N-Diethyl-1,4-phenylenediamine Dihydrochloride
• CAS NO: 16713-15-8
• Molecular Formula: C₁₀H₁₈N₂*2Cl
• Molecular Weight: 237.17
• EINECS: 240-760-2
• Mol File: 16713-15-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 272°Cat760mmHg
• Flash Point: 102.3°C
• Appearance: /
• Density: 1.072g/cm³
• Vapor Pressure: 4.47E-05mmHg at 25°C
• Water Solubility: almost transparency
• CAS DataBase Reference: N,N-DIETHYL-1,4-PHENYLENEDIAMINE DIHYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-DIETHYL-1,4-PHENYLENEDIAMINE DIHYDROCHLORIDE(16713-15-8)
• EPA Substance Registry System: N,N-DIETHYL-1,4-PHENYLENEDIAMINE DIHYDROCHLORIDE(16713-15-8)

Safety Data

• Hazardous Substances Data: 16713-15-8(Hazardous Substances Data)

Usage

Purification Methods

Crystallise the salt from EtOH. The free base [93-05-0] M 164.2 distils at 260-262o/~760mm.[Beilstein 14 IV 109.]

InChI:InChI=1/C10H16N2.2ClH/c1-3-12(4-2)10-7-5-9(11)6-8-10;;/h5-8H,3-4,11H2,1-2H3;2*1H

Upstream product

• 93-05-0 N,N-diethylaniline 

Downstream Products

• 148-90-3 4-diethylamino-benzenediazonium; chloride 
• 115122-71-9 sodium 1-amino-4-(diethylamino)-2-benzenesulfonate 
• 123135-50-2 4--1,2-naphthoquinone 
• 121501-64-2 7-chloro-2-(p-diethylaminophenyl)-2H-benzotriazolyl-5-amine 
• 121501-63-1 2-[4-(diethylamino)phenyl]-2H-benzotriazol-5-amine 
• 3009-34-5 quinoneimine 
• 76614-86-3 Diethyl-(4-oxo-cyclohexa-2,5-dienylidene)-ammonium 

Relevant articles and documents

Thioninium compounds and their use

This invention pertains generally to processes, uses, methods and materials utilising particular diaminophenothiazinium compounds, specifically, ETC, DEMTC, DMETC, DEETC, MTZ, ETZ, MTI, MTI.HL, ETI, ETI.HL, MTN, and ETN. These compounds are useful as drugs, for example, in the treatment of tauopathies, such as Alzheimer's disease.

METHODS OF CHEMICAL SYNTHESIS AND PURIFICATION OF DIAMINOPHENOTHIAZINIUM COMPOUNDS INCLUDING METHYLTHIONINIUM CHLORIDE (MTC)

This invention pertains generally to the field of chemical synthesis and purification, and more specifically to methods of synthesizing and purifying certain 3,7 diamino-phenothiazin-5-ium compounds (referred to herein as "diaminophenothiazinium compounds") including Methythioninium Chloride (MTC) (also known as Methylene Blue). In one embodiment, the method comprises the steps of, in order: nitrosylation (NOS); nitrosyl reduction (NR); thiosulfonic acid formation (TSAF); oxidative coupling (OC); Cr(VI) reduction (CR); isolation and purification of zwitterionic intermediate (IAPOZI); ring closure (RC); chloride salt formation (CSF); one of: sulphide treatment (ST); dimethyldithiocarbamate treatment (DT); carbonate treatment (CT); ethylenediaminetetraacetic acid treatment (EDTAT); organic extraction (OE); and recrystallisation (RX). The present invention also pertains to the resulting (high purity) compounds, compositions comprising them (e.g., tablets, capsules), and their use in methods of inactivating pathogens, and methods of medical treatment and diagnosis, etc., for example, for tauopathies, Alzheimer's disease (AD), skin cancer, melanoma, viral diseases, bacterial diseases, or protozoal diseases.