167215-77-2

Upstream product

• 6908-41-4 4-(methoxycarbonyl)benzyl alcohol 
• 124-63-0 methanesulfonyl chloride 
• 99-75-2 4-methyl-benzoic acid methyl ester 
• 1001-62-3 bis(methanesulfonyl)peroxide 

Downstream Products

• 167215-78-3 N-[4-(carbomethoxy)benzyl]-N,N'-bis[(2-triphenylmethylthio)ethyl]glycinamide 
• 908288-87-9 C₂₅H₃₁NO₃ 
• 162554-06-5 methyl 4-(4-cyanobenzyl)benzoate 
• 905818-70-4 methyl 4-{[(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)amino]methyl}benzoate 
• 167215-80-7 N-[4-(Carboxy)benzyl]-N,N'-bis[(2-triphenylmethyl-thio)ethyl]glycinamide N-hydroxysuccinimide ester 
• 167215-79-4 N-[4-(Carboxy)benzyl]-N,N'-bis[(2-triphenylmethylthio)ethyl]glycinamide 
• 1571-08-0 methyl 4-formylbenzoate 
• 6908-41-4 4-(methoxycarbonyl)benzyl alcohol 
• 23450-30-8 methyl 4-benzylbenzoate 

Relevant academic research and scientific papers

Synthesis of Benzylic Alcohols by C-H Oxidation

Selective methylene C-H oxidation for the synthesis of alcohols with a broad scope and functional group tolerance is challenging due to the high proclivity for further oxidation of alcohols to ketones. Here, we report the selective synthesis of benzylic alcohols employing bis(methanesulfonyl) peroxide as an oxidant. We attempt to provide a rationale for the selectivity for monooxygenation, which is distinct from previous work; a proton-coupled electron transfer mechanism (PCET) may account for the difference in reactivity. We envision that our method will be useful for applications in the discovery of drugs and agrochemicals.

Cobalt-Catalyzed Formation of Functionalized Diarylmethanes from Benzylmesylates and Aryl Halides

A simple cobalt-catalyzed reductive coupling protocol allowing the synthesis of functionalized diarylmethanes from benzyl mesylate is described. The possibility to directly use the benzyl alcohol as a result of a two-step reaction is also presented. This method tolerates a variety of functional groups. A benzyl radical is likely involved. (Figure presented.).

Coupling of arylboronic acids with benzyl halides or mesylates without adding transition metal catalysts

We report herein a transition-metal-free coupling reaction of arylboronic acids with benzyl halides and mesylates for the construction of C(sp2)[sbnd]C(sp3) bonds. A unique feature of this coupling reaction is the formation regioisomers in some cases. Mechanistic studies suggest that this reaction may proceed via an unprecedented Friedel–Crafts-type reaction pathway under base conditions with the assistance of boronic acid moiety.

SELECTIVE HDAC6 INHIBITORS

The present invention provides hydroxamic acids of the formula described herein, that have activity toward inhibiting histone deacetylases, and in particular HDAC6. Also contemplated are pharmaceutical compositions and methods of use of an effective amount of the hydroxamic acid compounds provided, for treating a disease in a subject. In certain embodiments, the subject is afflicted with cancer, neurodegenerative disease, or HIV infection.

BENZAZOLE POTENTIATORS OF METABOTROPIC GLUTAMATE RECEPTORS

The present invention is directed to benzazole compounds which are potentiators of metabotropic glutamate receptors, including the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated wi