167263-11-8

Basic information

• Product Name: N-BOC-4-BENZYL-4-PIPERIDINECARBOXYLIC ACID
• Synonyms: N-BOC-4-BENZYL-4-PIPERIDINECARBOXYLIC ACID;1-BOC-4-(PHENYLMETHYL)-4-PIPERIDINECARBOXYLIC ACID;HONGHUI-MED 070070040000;4-benzyl-1-[(tert-butoxy)carbonyl]piperidine-4- carboxylic acid;1-Boc-4-benzyl-4-piperidinecarboxylic acid;4-Benzyl-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester
• CAS NO: 167263-11-8
• Molecular Formula: C₁₈H₂₅NO₄
• Molecular Weight: 319.4
• Mol File: 167263-11-8.mol

Chemical Properties

• Boiling Point: 456.9±38.0 °C(Predicted)
• Appearance: /
• Density: 1.167±0.06 g/cm3(Predicted)
• PKA: 4.44±0.20(Predicted)
• CAS DataBase Reference: N-BOC-4-BENZYL-4-PIPERIDINECARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: N-BOC-4-BENZYL-4-PIPERIDINECARBOXYLIC ACID(167263-11-8)
• EPA Substance Registry System: N-BOC-4-BENZYL-4-PIPERIDINECARBOXYLIC ACID(167263-11-8)

Safety Data

• Hazardous Substances Data: 167263-11-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
N-BOC-4-BENZYL-4-PIPERIDINECARBOXYLIC ACID is used as a key intermediate for the synthesis of various pharmaceuticals. Its unique structure, featuring the N-BOC protective group and the benzyl substituent, allows for the creation of a wide range of drug molecules with diverse therapeutic properties.
Used in Organic Synthesis:
In the field of organic synthesis, N-BOC-4-BENZYL-4-PIPERIDINECARBOXYLIC ACID is used as a building block for the assembly of complex organic molecules. The N-BOC group can be selectively removed under mild conditions, enabling the controlled formation of amines and other nitrogen-containing functional groups. This makes it a valuable component in the synthesis of natural products, agrochemicals, and other specialty chemicals.
Used in Medicinal Chemistry:
N-BOC-4-BENZYL-4-PIPERIDINECARBOXYLIC ACID is utilized in medicinal chemistry as a starting material for the development of new drug candidates. Its structural features can be modified through various chemical reactions, allowing researchers to explore its potential in treating a variety of diseases and medical conditions.
Used in Chemical Research:
In the realm of chemical research, N-BOC-4-BENZYL-4-PIPERIDINECARBOXYLIC ACID serves as a model compound for studying reaction mechanisms and exploring new synthetic methodologies. Its reactivity and functional group compatibility make it an ideal candidate for investigating novel chemical transformations and developing innovative synthetic strategies.
Overall, N-BOC-4-BENZYL-4-PIPERIDINECARBOXYLIC ACID is a valuable chemical entity with broad applications across various industries, including pharmaceuticals, organic synthesis, medicinal chemistry, and chemical research. Its unique structural features and synthetic versatility make it an essential component in the development of new drugs, organic compounds, and innovative synthetic methods.

Upstream product

• 1126-09-6 4-carbethoxypiperidine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 100-39-0 benzyl bromide 
• 209920-41-2 tert-butyl 4-(phenylmethylidene)piperidine-1-carboxylate 
• 124-38-9 carbon dioxide 
• 1449-46-3 benzyltriphenylphosphonium bromide 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 124443-68-1 1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate 
• 741687-06-9 1-tert-butyl 4-methyl 4-benzylpiperidine-1,4-dicarboxylate 

Downstream Products

• 741687-06-9 1-tert-butyl 4-methyl 4-benzylpiperidine-1,4-dicarboxylate 
• 897669-44-2 4-benzyl-piperidine-1,4-dicarboxylic acid 4-benzyl ester 1-tert-butyl ester 
• 1015069-92-7 C₂₈H₃₂N₄O₄ 
• 885499-61-6 CCT₁₂₈₉₃₀ 
• 885500-63-0 4-[4-amino-4-(4-chlorobenzyl)-piperidin-1-yl]-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester 
• 885653-43-0 4-(4-chlorobenzyl)-piperidin-4-ylamine 
• 956460-41-6 C₁₇H₂₅ClN₂O₂ 
• 885500-38-9 4-(4-chlorobenzyl)piperidin-4-ylamine dihydrochloride 
• 1227169-92-7 4-benzyl-4-[(pyridin-3-ylmethyl)-carbamoyl]-piperidine-1-carboxylic acid tert-butyl ester 
• 249921-24-2 4-benzyl-4-(N',N'-dimethylhydrazinocarbonyl)piperidine-1-carboxylic acid tert-butyl ester 
• 885653-42-9 4-benzylpiperidin-4-amine 
• 741687-09-2 tert-butyl 4-amino-4-benzylpiperidine-1-carboxylate 

Relevant articles and documents

Harnessing Applied Potential: Selective β-Hydrocarboxylation of Substituted Olefins

The construction of carboxylic acid compounds in a selective fashion from low value materials such as alkenes remains a long-standing challenge to synthetic chemists. In particular, β-addition to styrenes is underdeveloped. Herein we report a new electrosynthetic approach to the selective hydrocarboxylation of alkenes that overcomes the limitations of current transition metal and photochemical approaches. The reported method allows unprecedented direct access to carboxylic acids derived from β,β-trisubstituted alkenes, in a highly regioselective manner.

Amino-substituted heterocycles, compositions thereof, and methods of treatment therewith

Provided herein are Heterocyclic Compounds having the following structure: wherein R1, R2, X, Y and Z are as defined herein, compositions comprising an effective amount of a Heterocyclic Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, metabolic conditions and conditions treatable or preventable by inhibition of a kinase pathway comprising administering an effective amount of a Heterocyclic Compound to a patient in need thereof.

PHARMACEUTICAL COMPOUNDS

The invention provides a compound of the formula (I) or salts, solvates, tautomers or N-oxides thereof, wherein T is N or CR5; J1-J2 is N=C(R6), (R7)C=N, (R8)N-C(O), (R8)2C-C(O), N=N or (R7)C=C(R6); E is a monocyclic carbocyclic or heterocyclic group of 5 or 6 ring members, the heterocyclic group containing up to 3 heteroatoms selected from O, N and S; Q1 is a bond or a saturated C1-3 hydrocarbon linker group, one of the carbon atoms in the linker group being optionally be replaced by an oxygen or nitrogen atom, or an adjacent pair of carbon atoms may be replaced by CONRq or NRqCO where Rq is hydrogen or methyl, or Rq is a C1-4 alkylene chain linked to R1 or a carbon atom of Q1 to form a cyclic moiety; and wherein the carbon atoms of the linker group Q1 may optionally bear one or more substituents selected from fluorine and hydroxy; Q2 is a bond or a saturated hydrocarbon linker group containing from 1 to 3 carbon atoms, wherein one of the carbon atoms in the linker group may optionally be replaced by an oxygen or nitrogen atom; and wherein the carbon atoms of the linker group may optionally bear one or more substituents selected from fluorine and hydroxy, provided that the hydroxy group when present is not located at a carbon atom α with respect to the G group; and provided that when E is aryl or heteroaryl, then Q2 is other than a bond; G is hydrogen, NR2R3, OH or SH provided that when E is aryl or heteroaryl and Q2 is a bond, then G is hydrogen; R1 is hydrogen or an aryl or heteroaryl group, with the proviso that when R1 is hydrogen and G is NR2R3, then Q2 is a bond; and R2, R3, R4, R6 and R8 are as defined in the claims, wherein the compound is for use in: (a) the treatment or prophylaxis of a disease or condition in which the modulation (e.g. inhibition) of ROCK kinase or protein kinase P70S6K is indicated; and/or (b) the treatment of a subject or patient population in which the modulation (e.g. inhibition) of ROCK kinase or protein kinase P70S6K is indicated.

Pyridine, pyrimidine, quinoline, quinazoline, and naphthalene urotensin-II receptor antagonists

The present invention relates to urotensin II receptor antagonists, pharmaceutical compositions containing them and their use.

Facile synthesis of 4-substituted-4-aminopiperidine derivatives, the key building block of piperazine-based CCR5 antagonists

4-Substituted-4-aminopiperidine is an interesting structural motif found in a number of bioactive compounds. An efficient and convenient method for the synthesis of 4-differently substituted-4-aminopiperidine derivatives was described, employing isonipecotate as a starting material and Curtius rearrangement as a key step. The alkylation of isonipecotate could introduce various substituents at the 4-position of the piperidine ring. With this key building block, we are able to efficiently synthesize piperazino-piperidine based CCR5 antagonist in a highly convergent manner free of using toxic reagents such as diethylaluminum cyanide. The concise synthesis of a potent bioavailable CCR5 antagonist as HIV-1 entry inhibitor, Sch-350634 (1) was accomplished in excellent yield using N′-Boc-4-methyl-4-aminopiperidine 5a as a smart building block. The new methodology provides a facile and practical access to the piperazino-piperidine amide analogs as HIV-1 entry inhibitors.

Compounds with growth hormone releasing properties

Disclosed are 4,4-disubstituted and 3,3-disubstituted piperidine compounds of formula I wherein D, E, G, J, R1, a, b, c, and d are defined in the specification, compositions containing them, and their use for treating medical disorders resultin