209920-41-2

Basic information

• Product Name: 1-Piperidinecarboxylic acid, 4-(phenylmethylene)-, 1,1-dimethylethyl ester
• CAS NO: 209920-41-2
• Molecular Formula: C17H23NO2
• Molecular Weight: 273.375
• Mol File: 209920-41-2.mol

Chemical Properties

• CAS DataBase Reference: 1-Piperidinecarboxylic acid, 4-(phenylmethylene)-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperidinecarboxylic acid, 4-(phenylmethylene)-, 1,1-dimethylethyl ester(209920-41-2)
• EPA Substance Registry System: 1-Piperidinecarboxylic acid, 4-(phenylmethylene)-, 1,1-dimethylethyl ester(209920-41-2)

Safety Data

• Hazardous Substances Data: 209920-41-2(Hazardous Substances Data)

Upstream product

• 1449-46-3 benzyltriphenylphosphonium bromide 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 100-39-0 benzyl bromide 
• 1100-88-5 benzyltriphenylphosphonium chloride 

Downstream Products

• 167263-11-8 N-tert-butyloxycarbonyl-4-benzylpiperidine-4-carboxylic acid 
• 305794-71-2 4-(1-Bromo-1-phenyl-methylene)-piperidine-1-carboxylic Acid tert-butyl Ester 

Relevant articles and documents

Harnessing Applied Potential: Selective β-Hydrocarboxylation of Substituted Olefins

The construction of carboxylic acid compounds in a selective fashion from low value materials such as alkenes remains a long-standing challenge to synthetic chemists. In particular, β-addition to styrenes is underdeveloped. Herein we report a new electrosynthetic approach to the selective hydrocarboxylation of alkenes that overcomes the limitations of current transition metal and photochemical approaches. The reported method allows unprecedented direct access to carboxylic acids derived from β,β-trisubstituted alkenes, in a highly regioselective manner.

Synthesis of O- tert-Butyl- N,N-disubstituted Hydroxylamines by N-O Bond Formation

The reaction of magnesium amides with tert-butyl 2,6-dimethyl perbenzoate in tetrahydrofuran at 0 °C provides a method for the synthesis O-tert-butyl-N,N-disubstituted hydroxylamines by direct N-O bond formation with a broad functional group tolerance. Less sterically hindered magnesium amides require ortho,ortho-disubstitution on the perester electrophile component, whereas sterically encumbered magnesium amides perform comparably with either tert-butyl perbenzoate or tert-butyl 2,6-dimethyl perbenzoate. A reaction mechanism is presented to account for the observed reactivity.

DOPAMINE D3 RECEPTOR ANTAGONISTS COMPOUNDS

The disclosure is directed to novel dopamine D3 receptor antagonists, processes for their preparation, intermediates used in these processes, pharmaceutical compositions containing them and their use in therapy, including treating drug dependency and psychosis.

Indole, azaindole and related heterocyclic 4-alkenyl piperidine amides

This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with new piperidine 4-alkenyl derivatives that possess unique antiviral activity. More particularly, the present invention relates to compounds useful for the treatment of HIV and AIDS. The compounds of the invention for the general Formula I: wherein: Z is Q is selected from the group consisting of: —W— is

Indole, azaindole and related heterocyclic 4-alkenyl piperidine amides

This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with new piperidine 4-alkenyl derivatives that possess unique antiviral activity. More particularly, the present invention relates to compounds useful for the treatment of HIV and AIDS. The compounds of the invention for the general Formula I: wherein: Z is Q is selected from the group consisting of: —W— is