167281-71-2Relevant academic research and scientific papers
Enantioselective Stereodivergent Nucleophile-Dependent Isothiourea-Catalysed Domino Reactions
Matviitsuk, Anastassia,Taylor, James E.,Cordes, David B.,Slawin, Alexandra M. Z.,Smith, Andrew D.
supporting information, p. 17748 - 17757 (2016/11/29)
α,β-Unsaturated acyl ammoniums generated from the reaction of α,β-unsaturated 2,4,6-trichlorophenol (TCP) esters bearing a pendent enone with an isothiourea organocatalyst are versatile intermediates in a range of enantioselective nucleophile-dependent domino processes to form complex products of diverse topology with excellent stereoselectivity. Use of either 1,3-dicarbonyls, acyl benzothiazoles, or acyl benzimidazoles as nucleophiles allows three distinct, diastereodivergent domino reaction pathways to be accessed to form various fused polycyclic cores containing multiple contiguous stereocentres.
Synthesis and tautomerism of 2-phenacyl-1H-benzimidazoles and their hydrogen bromide salts
Dzvinchuk,Nesterenko,Polovinko,Ryabitskii,Lozinskii
experimental part, p. 953 - 963 (2012/03/26)
2-Phenacyl-1H-benzimidazoles were prepared by the acylation of 2-methylbenzimidazole using aroyl chlorides with subsequent alcoholysis or aminolysis of the N,C,O-triacylation products obtained. Treatment of the 2-phenacyl-1H-benzimidazoles with hydrobromic acid gave the corresponding salts. The structure of the products was supported by IR, 1H and 13C NMR, and HMBC spectroscopy as well as by quantum-chemical calculations. 2-Phenacyl-1H-benzimidazoles in DMSO-d6 solution were found to display predominantly imino-enamino tautomerism, while their salts were found to display predominantly keto-enol tautomerism.
Propane-1,3-dione derivatives
-
Page/Page column 23, (2008/06/13)
Provided is a pharmaceutical composition containing a propane-1,3-dione derivative as the active ingredient, particularly a GnRH receptor antagonist. Also, provided is a propane-1,3-dione derivative having a GnRH antagonistic effect.
C-MONOBENZOYLATION AND DIBENZOYLATION OF 2-METHYLBENZIMIDAZOLE WITH BENZOYL CHLORIDE
Dzvinchuk, I.B.,Lozinskii, M.O.,Vypirailenko, A.V.
, p. 971 - 976 (2007/10/02)
The reaction of 2-methylbenzimidazole with benzoyl chloride in the presence of triethylamine leads to the formation of N-, C-, and O-polybenzoylation products.C-Dibenzoylation takes place at elevated temperatures and is facilitated by the addition of benzoic acid or small amounts of water, which promote the formation of benzoic acid, to the reaction mixture after the C-monobenzoylation stage.
