16732-80-2

Basic information

• Product Name: 1H-Indole-2-carboxylic acid, 4-Methyl-, ethyl ester
• Synonyms: 1H-Indole-2-carboxylic acid, 4-Methyl-, ethyl ester;Ethyl 4-Methyl-1H-indole-2-carboxylate;4-methyl-1H-indole-2-carboxylic acid ethyl ester;4-Methylindole-2-carboxylic acid ethyl ester, 98%
• CAS NO: 16732-80-2
• Molecular Formula: C₁₂H₁₃NO₂
• Molecular Weight: 203.23712
• Mol File: 16732-80-2.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1H-Indole-2-carboxylic acid, 4-Methyl-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole-2-carboxylic acid, 4-Methyl-, ethyl ester(16732-80-2)
• EPA Substance Registry System: 1H-Indole-2-carboxylic acid, 4-Methyl-, ethyl ester(16732-80-2)

Safety Data

• Hazardous Substances Data: 16732-80-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1H-Indole-2-carboxylic acid, 4-methyl-, ethyl ester is used as a key intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of anti-inflammatory and anti-cancer medications. Its chemical structure allows for the creation of diverse drug candidates that can target specific biological pathways and mechanisms, offering potential therapeutic benefits in treating various diseases.
Used in Organic Compounds Synthesis:
In the field of organic chemistry, 1H-Indole-2-carboxylic acid, 4-methyl-, ethyl ester serves as a valuable starting material for the production of a wide range of organic compounds. Its unique structure facilitates various chemical reactions, enabling the synthesis of complex molecules with specific properties and applications.
Used in Laboratory Research:
1H-Indole-2-carboxylic acid, 4-methyl-, ethyl ester is utilized in laboratory research for studying its chemical properties, reactivity, and potential applications in various chemical and biological processes. Researchers use 1H-Indole-2-carboxylic acid, 4-methyl-, ethyl ester to explore new synthetic routes, investigate its interactions with other molecules, and understand its role in the development of new pharmaceutical agents.
Overall, 1H-Indole-2-carboxylic acid, 4-methyl-, ethyl ester is a crucial compound in the pharmaceutical and chemical industries, with its applications spanning from drug development to organic synthesis and laboratory research. Its unique properties and versatile structure make it an essential component in the pursuit of innovative and effective treatments for various health conditions.

Upstream product

• 4966-38-5 (E)-ethyl pyruvate 2-(2-methylphenyl)hydrazone 
• 529-20-4 2-methylphenyl aldehyde 
• 83-41-0 2,3-dimethylnitrobenzene 
• 24512-97-8 azide 
• 18474-57-2 4-methyl-1H-indole-2-carboxylic acid 
• 64-17-5 ethanol 
• 796069-22-2 4-methylindole-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester 
• 70467-01-5 (2-methyl-6-nitro-phenyl)-pyruvic acid 
• 81803-45-4 ethyl 2-azido-3-(2-methylphenyl)propenoate 

Downstream Products

• 50536-58-8 5-bromo-4-methyl-1H-indole-2-carboxylic acid 
• 229951-10-4 1-(3-carbamimidoyl-benzyl)-4-methyl-1H-indole-2-carboxylic acid 3-carbamimidoyl-benzylamide 
• 18474-57-2 4-methyl-1H-indole-2-carboxylic acid 
• 229953-80-4 1-(3-cyano-benzyl)-4-methyl-1H-indole-2-carboxylic acid (4-dimethylamino)-benzyl amide 
• 58518-51-7 4-monomethylindolecarboxaldehyde 

Relevant articles and documents

Regioselective Functionalization of 4-Methyl-1H-indole for Scalable Synthesis of 2-Cyano-5-formyl-4-methyl-1H-indole

We report a five-step synthesis of 2-cyano-5-formyl-4-methyl-1H-indole through sequential functionalization of readily available 4-methyl-1H-indole. Cyano and aldehyde functionalities are regioselectively installed at the 2 and 5 position, respectively. T

Three consecutive steps over the chirally modified Pt surface: Asymmetric catalytic cascade reaction of 2-nitrophenylpyruvates

The influence of the reaction conditions on the asymmetric heterogeneous cascade reaction of 2-nitrophenylpyruvates over Pt catalysts modified with cinchonidine leading to (R)-3-hydroxy-3,4-dihydroquinolin-2(1H)-one derivatives has been studied. Results of studies on the amount of acetic acid or catalyst, nature of the Pt support, kinetic examinations, effect of H2 pressure, and modifier and substrate concentrations showed that all three steps of this catalytic cascade take place on the Pt surface, with the nitro group reduction immediately following the enantioselective hydrogenation of the keto group, whereas the final intramolecular amidation was preceded by desorption after complete reduction of the substrate and re-adsorption of the corresponding intermediate.

ZrCl4-promoted facile synthesis of indole derivatives

Zirconium(iv) chloride effectively activates nitrogen (N2) extrusion from aryl azidoacrylates followed by annulation to provide the desired indole products in moderate to good yields. The reaction proceeds at low temperature and in short reaction time and is applicable to a variety of substrates.

INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful

Heterocyclyl-substituted dihydroquinazolines and their use as antiviral agents

The invention relates to heterocyclyl-substituted dihydroquinazolines of formula (I), to processes for their preparation, to medicaments containing them, and to methods for the treatment and/or prophylaxis of diseases, in particular, for use as anti-viral agents, in particular, against cytomegaloviruses.

Novel triazole derivatives, process for their preparation and pharmaceutical compositions containing them

The invention relates to a compound of formula in which R1, X1, X2, X3, X4, R4, Y1, Y2 and Y3 are as defined in claim 1. These compounds are CCK-receptor agonists.

HETEROCYCLYL-SUBSTITUTED DIHYDROQUINAZOLINES AND USE THEREOF AS AN ANTIVIRAL AGENT

The invention relates to heterocyclyl-substituted dihydroquinazolines of formula (I), methods for the production and use thereof for the production of medicaments for the treatment and/or prophylaxis of diseases, in particular, for use as anti-viral agents, in particular, against cytomegaloviruses.

Tripeptidyl peptidase inhibitors

The invention is relative to a compound of formula (I) and its use as an inhibitor of the CCK-inactivating peptidase tripeptidyl peptidase (TPP II). The invention concerns in particular the treatment of eating disorder, obesity, psychotic syndrome and associated psychiatric disorders. It concerns also the cosmetic use of a compound (I) in particular to aid slimming.

INDOLE- AND BEZIMIDAZOLE-SUBSTITUTED QUINOLINE DERIVATIVES

Compounds of the formula STR1 wherein X, R 1, R 2, R 3, R 4, R 5, R 6 and R 7 are as defined herein. These compounds inhibit the action of angiotensin II and are useful, therefore, for example, as antihypertensive agents.

Fischer indolization of variously ortho-substituted phenylhydrazones (Fischer indolization and its related compounds. XXV)

Various kinds of ethyl pyruvate 2-(2-substituted phenyl)hydrazones (1) were subjected to Fischer indolization with acid catalysts. All the phenylhydrazones gave corresponding normal 7-substituted indoles (2). In addition, phenylhydrazones whose ortho-substituent is electron-donative or has a central atom with an unshared electron pair tended to give the 4- or 5- substituted indole (3), which was produced by migration of the ortho- substituent during cyclization, whereas those whose ortho-substituent is electron-attractive tended to give little or no such abnormal product. The kind of acid catalyst used had some effect on the yield ratio of products but not on the kind of products.