16737-71-6

Upstream product

• 576-22-7 2-Bromo-m-xylene 
• 107-21-1 ethylene glycol 
• 576-26-1 2.6-dimethylphenol 
• 540-51-2 2-bromoethanol 
• 107-07-3 2-chloro-ethanol 
• 75-21-8 oxirane 
• 96-49-1 [1,3]-dioxolan-2-one 
• 6279-47-6 ethyl 2-(2,6-dimethylphenoxy)acetate 
• 445283-38-5 2-[2-(2,6-dimethyl-phenoxy)-ethoxy]-tetrahydro-pyran 

Downstream Products

• 227750-60-9 (2,6-dimethyl)-phenoxyethyl-4-toluenesulfonate 
• 72102-89-7 2,6-dimethylphenoxyacetaldehyde 
• 38285-13-1 2-(2-chloroethyl)-1,3-dimethylbenzene 
• 1347727-76-7 trans-(±)-4N-[(2,6-dimethylphenoxy)ethyl]aminocyclohexan-1-ol 
• 39085-53-5 Essigsaeure-<2-(2,6-dimethyl-phenoxy)-ethylester> 
• 116773-67-2 [2-(2,6-dimethyl-phenoxy)-ethyl]-4-toluenesulfonate 
• 37136-92-8 2-(2,6-Dimethyl-phenoxy)-1-bromo-ethane 

Relevant academic research and scientific papers

A photopolymerization initiator, and ink composition using the same

PROBLEM TO BE SOLVED: To provide a compound useful as a water soluble photopolymerization initiator, and an ink composition containing the same.SOLUTION: A compound is represented by general formula (1) [in general formula (1), each of Rto Rindependently represents a hydrogen atom or a substituent, however, at least one of Rto Ris a group represented by R-X-* (wherein Xrepresents an oxygen atom or a sulfur atom, Rrepresents a substituent, and * represents a site connecting with a benzene ring), also Rrepresents a substituent other than an aryl group and a heterocyclic group, and two or more Rs may be identical to or different from one another].

Copper(ii)-catalyzed C-O coupling of aryl bromides with aliphatic diols: Synthesis of ethers, phenols, and benzo-fused cyclic ethers

A highly efficient copper-catalyzed C-O cross-coupling reaction between aryl bromides and aliphatic diols has been developed employing a cheaper, more efficient, and easily removable copper(ii) catalyst. A broad range of aryl bromides were coupled with aliphatic diols of different lengths using 5 mol% CuCl2 and 3 equivalents of K2CO3 in the absence of any other ligands or solvents to afford the corresponding hydroxyalkyl aryl ethers in good to excellent yields. In this newly developed protocol, aliphatic diols have multilateral functions as coupling reactants, ligands, and solvents. The resulting hydroxyalkyl aryl ethers were further readily converted into the corresponding phenols, presenting a valuable alternative way to phenols from aryl bromides. Furthermore, it was demonstrated that they are useful intermediates for more advanced molecules such as benzofurans and benzo-fused cyclic ethers. This journal is

Zirconium complexes with pendant aryloxy groups attached to the metallocene moiety by ethyl or hexyl spacers

Four zirconium complexes with pendant aryloxy groups attached to the metallocene moiety by ethyl or hexyl spacers have been synthesized and characterized by spectroscopic methods and HR-MS or elemental analysis. The solid state structure of bis[{6-(2,6-dimethylphenoxy)hexyl}cyclopentadienyl] zirconium dichloride was determined by single crystal X-ray diffraction. The prepared complexes were tested as catalyst precursors in the polymerization of ethylene upon activation with MAO. The results showed a marked effect of the spacer length on the catalytic activity, while only a minor effect of the substitution on the aryl group, which affected its steric properties.

Microwave mediated protection of hindered phenols and alcohols

Hindered phenols and alcohols were protected as their corresponding ethers using different alkylating agents in presence of KOH/DMSO under microwave irradiation.

β-Hydroxyalkylation of sterically hindered phenols with epoxides in acid medium

Reactions of 2,6-dialkylphenols with ethylene oxide, propylene oxide and epichlorohydrin in the presence of SnCl4 at the temperature from -5 to +5°C leads to the formation of respective phenols containing a hydroxy group in the β-position of the aliphatic chain of the para-substituent. The conditions for maximum selectivity of the reaction of 2,6-di-tert-butylphenol with ethylene oxide were determined. By HPLC-MS method the directions of the side reactions were explored. The method has been successfully tested in a pilot installation. With 2,6-dimethylphenol instead of 2,6-di-tert-butylphenol a sharp increase occurs in the content of ethers in the reaction product. With epichlorohydrin, 2,6-di-tert-butylphenol affords a product, which is easily converted into an epoxide containing a sterically hindered phenol in its structure.

SALICYLIC ACID DERIVATIVE COMPOUND AND PHARMACEUTICAL COMPOSITION CONTAINING THEM

The present invention provides the salicylic acid derivative compound or its pharmaceutically acceptable salt useful for treating several diseases, a pharmaceutical composition containing the compound or its salt, and a treating or preventing method using the compound or its salt. The salicylic acid derivative compound of the present invention has suppressing effect on excitatory toxicity, anti-oxidant effect, cell-protecting effect, anti-inflammatory effect, etc. and can be effectively used for treating or preventing brain neuronal disease such as amyotrophic lateral sclerosis, Parkinson' s disease, Huntington' s disease, Alzheimer' s disease, stroke, traumatic brain injury and traumatic spinal cord injury; ocular disease such as glaucoma, diabetic retinopathy and macular degeneration; pain disease such as neuropathic pain; and inflammatory disease such as arteriosclerosis, gastritis, colitis, arthritis, nephritis, hepatitis, cancer and degenerative disease.

Omega-hydrofluoroalkyl ethers, precursor carboxylic acids and derivatives thereof, and their preparation and application

Normally liquid, omega-hydrofluoroalkyl ether compounds (and selected mixtures thereof) have a saturated perfluoroaliphatic chain of carbon atoms interrupted by one or more ether oxygen atoms. The compounds can be prepare, e.g. by decarboxylation of the corresponding fluoroalkyl ether carboxylic acids and are useful, e.g., in cleaning and drying applications.

Design, synthesis, and biological evaluation of aryloxyethyl thiocyanate derivatives against Trypanosoma cruzi

As a continuation of our project aimed at the search for new and safe chemotherapeutic and chemoprophylactic agents against American trypanosomiasis (Chagas' disease), several drugs structurally related to 4-phenoxyphenoxyethyl thiocyanate (4) were designed, synthesized, and evaluated as antiproliferative agents against the parasite responsible for this disease, the hemoflagellated protozoan Trypanosoma cruzi. This thiocyanate derivative was previously shown to be an effective and potent agent against T. cruzi proliferation. Several drugs possessing thiocyanate groups proved to be effective growth inhibitors of T. cruzi growth. Among the designed compounds, it is important to point out the extremely potent activity shown by 11, 23, 38, 53, 90, 99, and 117 against the epimastigote forms of the parasite. All of them exhibited IC50 values in the low micromolar range, and these values were comparable with those presented by our lead drug 4 and ketokonazole, a well-known antiparasitic agent. The activity displayed by the nitrogen-containing derivative 90 was very promising with IC50 values of 3.3 μM. Several other thiocyanate derivatives also proved to be very potent inhibitors of the multiplication of T. cruzi epimastigotes, such as compounds 28, 33, 43, 48, 56, 61, 66, 71, 76, and 124. Compound 43 resulted in being a promising drug because it was also very effective against amastigotes, the clinically more relevant form of the parasite. This compound was 3-fold more potent than 4, while 11 showed nearly the same activity as our lead drug against intracellular T. cruzi. It was very surprising that the experimental juvenoid 124, although fairly devoid of activity against epimastigotes, was very effective against intracellular amastigotes growing in myoblasts. The rest of the designed compounds showed a broad degree of inhibitory action, from moderately active drugs to drugs almost devoid of antiparasitic activity. Compound 43 is an interesting example of an effective antichagasic agent that presents excellent prospectives not only as a lead drug but also to be used for further in vivo studies.