167408-63-1

Basic information

• Product Name: Methyl 3-tert-butyl-1-Methyl-1H-pyrazole-5-carboxylate
• Synonyms: Methyl 3-tert-butyl-1-Methyl-1H-pyrazole-5-carboxylate;5-tert-Butyl-2-methyl-2H-pyrazole-3-carboxylic acid methyl ester
• CAS NO: 167408-63-1
• Molecular Formula: C10H16N2O2
• Molecular Weight: 196.24624
• Mol File: 167408-63-1.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Methyl 3-tert-butyl-1-Methyl-1H-pyrazole-5-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 3-tert-butyl-1-Methyl-1H-pyrazole-5-carboxylate(167408-63-1)
• EPA Substance Registry System: Methyl 3-tert-butyl-1-Methyl-1H-pyrazole-5-carboxylate(167408-63-1)

Safety Data

• Hazardous Substances Data: 167408-63-1(Hazardous Substances Data)

Upstream product

• 42957-17-5 methyl 5,5-dimethyl-2,4-dioxohexanoate 
• 77-78-1 dimethyl sulfate 
• 75-97-8 3,3-dimethyl-butan-2-one 
• 67-56-1 methanol 
• 175277-11-9 3-(tert-butyl)-1-methyl-1H-pyrazole-5-carboxylic acid 

Relevant articles and documents

Ligand-Promoted C(sp3)-H Olefination en Route to Multi-functionalized Pyrazoles

A Pd-catalyzed/N-heterocycle-directed C(sp3)-H olefination has been developed. The monoprotected amino acid ligand (MPAA) is found to significantly promote Pd-catalyzed C(sp3)-H olefination for the first time. Cu(OAc)2 instead of Ag+ salts are used as the terminal oxidant. This reaction provides a useful method for the synthesis of alkylated pyrazoles. The right moves: A pyrazole-directed C(sp3)-H olefination has been developed (see scheme). The monoprotected amino acid ligands (MPAA) are found to significantly promote the reactivity in Pd-catalyzed C(sp3)-H olefination. The applicability of using this reaction for late-stage diversification of pyrazole-based complex scaffold is demonstrated.