42957-17-5

Upstream product

• 75-97-8 3,3-dimethyl-butan-2-one 
• 95-92-1 oxalic acid diethyl ester 
• 553-90-2 Dimethyl oxalate 
• 7664-93-9 sulfuric acid 
• 124-41-4 sodium methylate 

Downstream Products

• 55107-14-7 Methyl 4,4-dimethyl-3-oxopentanoate 
• 103653-53-8 2-[(4-Dimethylamino-benzoyl)-hydrazono]-5,5-dimethyl-4-oxo-hexanoic acid methyl ester 
• 103653-54-9 2-[(4-Methoxy-benzoyl)-hydrazono]-5,5-dimethyl-4-oxo-hexanoic acid methyl ester 
• 70997-30-7 methyl 5,5-dimethyl-4-oxo-2-[2-(phenylcarbonyl)hydrazinylidene]hexanoate 
• 70997-31-8 methyl 5,5-dimethyl-4-oxo-2-[2-(phenylcarbonyl)hydrazinylidene]hexanoate 
• 103653-57-2 5,5-Dimethyl-2-[(4-nitro-benzoyl)-hydrazono]-4-oxo-hexanoic acid methyl ester 
• 103653-55-0 5,5-Dimethyl-2-[(4-methyl-benzoyl)-hydrazono]-4-oxo-hexanoic acid methyl ester 
• 103653-56-1 2-[(4-Bromo-benzoyl)-hydrazono]-5,5-dimethyl-4-oxo-hexanoic acid methyl ester 
• 109690-36-0 2,2-dimethyl-1-(1-phenyl-1H-pyrazol-4-yl)-propan-1-one 
• 130188-01-1 4-(2,2-dimethyl-1-oxopropyl)-1-phenyl-1H-pyrazole-5-carboxylic acid 
• 130188-00-0 4-(2,2-Dimethyl-propionyl)-2-phenyl-2H-pyrazole-3-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Synthesis, Acaricidal Activity, and Structure-Activity Relationships of Pyrazolyl Acrylonitrile Derivatives

A series of novel pyrazolyl acrylonitrile derivatives was designed, targeting Tetranychus cinnabarinus, and synthesized. Their structures were identified by combination of1H NMR,13C NMR, and MS spectra. The structures of compounds 18 and 19 were further confirmed by X-ray diffraction. Extensive greenhouse bioassays indicated that compound 19 exhibits excellent acaricidal activity against all developmental stages of T. cinnabarinus, which is better than the commercialized compounds cyenopyrafen and spirodiclofen. It was shown that the acute toxicity of compounds 19 to mammals is quite low. The structure-activity relationships are also discussed.

Evidence for Ketene Intermediates in the Decarbonylation of 2,4-Dioxo Acids and Esters and 2-Oxobutanedioic Acid Esters

The mechanism by which α,γ-dioxo carboxylic acid esters 1 and 2-oxobutanedioic acid diesters 2 lose CO was explored.The compounds, 5,5-dimethyl-2,4-dioxohexanoic acid ethyl ester, 1a, α-2-dioxocyclohexaneacetic acid ethyl ester, 1b, and α,1-dioxotetrahydro-2-naphthaleneacetic acid ethyl ester, 1c, lose CO at 170-190 deg C to yield the corresponding β-keto esters 3a-c.When compounds 1 or the parent acids 4 were heated to 170-190 deg C with water in a sealed reactor, they yielded ketones resulting from replacement by H of C(O)CO2R from 1 or C(O)CO2H from 4. β-Ketoesters suffered replacement by H of the carbethoxy group to yield the corresponding ketones when heated with water at about 105 deg C.Acylketenes, such as 4,4-dimethyl-1-pentene-1,3-dione, 6a, 2-oxo-cyclohexylidenemethanone, 6b, 1-oxotetrahydro-2-naphthylidenemethanone, 6c, 3-methyl-1-butene-1,3-dione, 6d, and 1-butene-1,3-dione, 6e, are implicated as the common intermediates that react with water to form β-keto acids that subsequently decarboxylateto yield the ketones 5.Intense IR frequencies in the region of 2120-2140 cm-1, characteristic of ketenes, are observed when 1, 2, or 3 is subjected to GC-FTIR analysis with the injector and light pipe at 280 deg C.Loss of carbon monoxide and alcohol at high temperature is required to form 6 from 1, while only the loss of alcohol at lower temperature is needed to form 6 from 3.

Process for the preparation of pivaloylpyruvic acid esters

An improved process for the preparation of pivaloylpyruyic acid ester by reaction of pinacolin with an oxalic acid dialkyl ester followed by neutralization of the reaction mixture is disclosed, wherein the reactants are mixed at a temperature of -50° to +