Methyl 3-tert-butyl-1-Methyl-1H-pyrazole-5-carboxylate

Base Information

• Chemical Name: Methyl 3-tert-butyl-1-Methyl-1H-pyrazole-5-carboxylate
• CAS No.: 167408-63-1
• Molecular Formula: C₁₀H₁₆N₂O₂
• Molecular Weight: 196.249
• Mol file: 167408-63-1.mol

Synonyms:

Chemical Property of Methyl 3-tert-butyl-1-Methyl-1H-pyrazole-5-carboxylate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

5-tert-Butyl-2-methyl-2H-pyrazole-3-carboxylicacidmethylester 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methyl 3-tert-butyl-1-Methyl-1H-pyrazole-5-carboxylate

There total 4 articles about Methyl 3-tert-butyl-1-Methyl-1H-pyrazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + 3-(tert-butyl)-1-methyl-1H-pyrazole-5-carboxylic acid (175277-11-9) → methyl 3-(tert-butyl)-1-methyl-1H-pyrazole-5-carboxylate (167408-63-1)

Guidance literature:

3-(tert-butyl)-1-methyl-1H-pyrazole-5-carboxylic acid; With oxalyl dichloride; In dichloromethane; at 20 ℃; for 2h;

methanol; In dichloromethane; at 20 ℃;

DOI:10.1002/chem.201600704

Reference yield:

3,3-dimethyl-butan-2-one (75-97-8) → methyl 3-(tert-butyl)-1-methyl-1H-pyrazole-5-carboxylate (167408-63-1)

Guidance literature:

Multi-step reaction with 3 steps

1: methanol

2: hydrazine hydrate / dichloromethane

3: dichloromethane

With hydrazine hydrate; In methanol; dichloromethane;

DOI:10.1021/acs.jafc.6b04221

Reference yield:

methyl 5,5-dimethyl-2,4-dioxohexanoate (42957-17-5) → methyl 3-(tert-butyl)-1-methyl-1H-pyrazole-5-carboxylate (167408-63-1)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / dichloromethane

2: dichloromethane

With hydrazine hydrate; In dichloromethane;

DOI:10.1021/acs.jafc.6b04221

upstream raw materials:

methanol

3-(tert-butyl)-1-methyl-1H-pyrazole-5-carboxylic acid

3,3-dimethyl-butan-2-one

dimethyl sulfate