167641-89-6

Upstream product

• 4104-89-6 triphenylpropargyl stannane 
• 167641-88-5 Benzoic acid (2R,3S,5R)-3-iodo-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 
• 70838-44-7 2,3'-anhydro-5'-O-benzoyl-2'-deoxythymidine 
• 169382-16-5 1-(5-benzoyl-3-bromo-2,3-dideoxy-β-D-erythro-pentofuranosyl)thymine 

Relevant academic research and scientific papers

Radical Mediated Synthesis of 3'-α-C-allenyl-2',3'-dideoxythymidine as a non-polar analogue of AZT

The 1,2-propadienyl (allenyl) group was selectively introduced at the 3'-α-C position by free radical C-C bond formation reaction involving triphenylprop-2-ynylstannane and protected 2',3'-dideoxy-3'-halogenothymidine.

Radical mediated synthesis of 3'-α-C-allenyl-2',3'-dideoxythymidine as a non-polar analogue of AZT

The synthesis of the novel modified nucleoside (1) exhibiting the 1,2- propadienyl [allenyl] group at the 3'-α-position is described. The 3'-C-C bond was formed by radical reaction between triphenylprop 2-ynylstannane (2) and the 3'-bromo(iodo)-2',3'-dide