Radical Mediated Synthesis of 3'-α-C-allenyl-2',3'-dideoxythymidine as a non-polar analogue of AZT

Article abstract of DOI:10.1016/0040-4039(94)02383-M

The 1,2-propadienyl (allenyl) group was selectively introduced at the 3'-α-C position by free radical C-C bond formation reaction involving triphenylprop-2-ynylstannane and protected 2',3'-dideoxy-3'-halogenothymidine.