3899-65-8

Usage

Uses

Due to the limited information available on the applications of BENZENE, 1-CHLORO-4,5-DIMETHOXY-2-NITRO-, it is challenging to provide a comprehensive list of its uses across different industries. However, based on the information provided, it can be inferred that the compound may be used in specialized chemical synthesis or research applications where its unique structure and properties are required. Further investigation and research would be necessary to identify specific industries and applications where BENZENE, 1-CHLORO-4,5-DIMETHOXY-2-NITRO- is employed.

InChI:InChI=1/C8H8ClNO4/c1-13-7-3-5(9)6(10(11)12)4-8(7)14-2/h3-4H,1-2H3

Upstream product

• 16766-27-1 4-chloro-1,2-dimethoxybenzene 
• 7697-37-2 nitric acid 
• 4998-07-6 4,5-dimethoxy-2-nitro-benzoic acid 
• 91-16-7 1,2-dimethoxybenzene 
• 37942-55-5 1-(4,5-Dimethoxy-2-nitrophenyl)-ethanol 
• 16766-30-6 4-Chloroguaiacol 

Downstream Products

• 14227-14-6 1,2,4-trimethoxy-5-nitrobenzene 
• 32829-09-7 2-chloro-4,5-dimethoxyaniline 
• 3865-12-1 5-chloro-2-methoxy-4-nitro-phenol 
• 76844-97-8 4-chloro-1,2-dihydroxy-5-nitrobenzene 
• 100960-04-1 4-methoxy-6-nitro-resorcinol 
• 5739-55-9 1-(3,4-Dimethoxy-phenylaethylamino)-2-nitro-4,5-dimethoxy-benzol 
• 4527-51-9 2-(4,5-dimethoxy-2-nitrophenylthio)acetic acid 
• 30058-31-2 5-Nitro-4-phenoxyveratrol 
• 171084-55-2 N,N-dimethyl-3,4-dimethoxy-6-nitroaniline 
• 121641-88-1 5,6-dimethoxy-2-amino-3-carbethoxyindole 
• 913837-98-6 ethyl 2-cyano-2-(4,5-dimethoxy-2-nitro-phenyl)-acetate 
• 2989-85-7 2-(4,5-Dimethoxy-2-nitro-phenylsulfanyl)-acetamide 
• 4604-95-9 (4,5-Dimethoxy-2-nitro-benzenesulfonyl)-acetic acid methyl ester 
• 4527-52-0 (4,5-dimethoxy-2-nitro-benzenesulfonyl)-acetic acid 

Relevant academic research and scientific papers

Dehydroxyalkylative halogenation of C(aryl)-C bonds of aryl alcohols

We herein report Cu mediated side-directed dehydroxyalkylative halogenation of aryl alcohols. C(aryl)-C bonds of aryl alcohols were effectively cleaved, affording the corresponding aryl chlorides, bromides and iodides in excellent yields. Aryl alcohols could serve as both aromatic electrophilic and radical synthetic equivalents during the reaction.

QUINAZOLINONE COMPOUNDS

New quinazolinone compounds are disclosed, as well as pharmaceutical compositions containing quinazolinones and methods for the treatment of diseases and conditions associated with mitochondrial dysfunction.

Inexpensive NaX (X = I, Br, Cl) as a halogen donor in the practical Ag/Cu-mediated decarboxylative halogenation of aryl carboxylic acids under aerobic conditions

Versatile and practical Ag/Cu-mediated decarboxylative halogenation between readily available aryl carboxylic acids and abundant NaX (X = I, Br, Cl) has been achieved under aerobic conditions in moderate to good yields. The halodecarboxylation is shown to be an effective strategy for S-containing heteroaromatic carboxylic acid and benzoic acids with nitro, chloro and methoxyl substituents at the ortho position. A gram-scale reaction and a three-step procedure to synthesize iniparib have been performed to evaluate the practicality of this protocol. A preliminary mechanistic investigation indicates that Cu plays a vital role and a radical pathway is involved in the transformation.

Synthetic method of aryl halide taking aryl carboxylic acid as raw material

A synthetic method of an aryl halide taking aryl carboxylic acid as a raw material is characterized in that a corresponding aryl halide is formed by carrying out substitution reaction on an aryl carboxylic acid compound and haloid salt MX in an organic solvent under the condition that oxygen, a silver catalyst, a copper additive and a bidentate nitrogen ligand exist, wherein M in MX represents alkali metal or alkaline earth metal, and X represents F, Cl, Br or I. Compared with a conventional aryl halide synthetic method, the synthetic method disclosed by the invention has the obvious advantages that reaction raw materials (comprising aryl carboxylic acid and MX) are cheap and easy to obtain, the using amount of a metal catalyst is small, pollution to the environment when the oxygen is used as an oxidant is the smallest, good tolerance to various functional groups on an aromatic ring is obtained, the yield is high, and the like. The synthetic method disclosed by the invention can be widely applied to synthesis in the fields of medicine, materials, natural products and the like in industry and academia.

Decarboxylative Halogenation and Cyanation of Electron-Deficient Aryl Carboxylic Acids via Cu Mediator as Well as Electron-Rich Ones through Pd Catalyst under Aerobic Conditions

Simple strategies for decarboxylative functionalizations of electron-deficient benzoic acids via using Cu(I) as promoter and electron-rich ones by employing Pd(II) as catalyst under aerobic conditions have been established, which lead to smooth synthesis of aryl halides (-I, Br, and Cl) through the decarboxylative functionalization of benzoic acids with readily available halogen sources CuX (X = I, Br, Cl), and easy preparation of benzonitriles from decarboxylative cyanation of aryl carboxylic acids with nontoxic and low-cost K4Fe(CN)6 under an oxygen atmosphere for the first time.

NITROGENATED FUSED RING DERIVATIVE, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, AND USE OF THE SAME FOR MEDICAL PURPOSES

[Purpose] The present invention provides compounds useful as agents for the prevention or treatment of a sex hormone-dependent disease or the like. [Solution] The present invention provides nitrogen-containing fused ring derivatives represented by the following general formula (I) which has a GnRH antagonistic activity, prodrugs, salts, pharmaceutical compositions containing the same, medicinal uses thereof and the like. In the formula (I), rings A and B are independently aryl or heteroaryl; RA and RB are independently halogen, cyano, alkyl, alkylsulfonyl, -OW1, -SW1, -COW2, -NW3W4, -SO2NW3W4, aryl, etc.; RC is H or alkyl; E is oxygen atom, etc.; U is single bond or alkylene; and X is Y, -CO-Y, -SO2-Y -S-(alkylene)-Y, -O-(alkylene)-Y, -SO2-(alkylene)-Y, etc.; Y is Z or amino, etc.; and Z is cycloalkyl, heterocycloalkyl, aryl, heteroaryl, etc.

Silver-catalyzed decarboxylative halogenation of carboxylic acids

Decarboxylative halogenation of carboxylic acids catalyzed by silver carbonate is reported. ortho-Nitrobenzoic acids react with copper(II) chloride or bromide in DMF/DMSO at 130-140 °C leading to the corresponding aryl halides in moderate to good yields.

PROTEIN KINASE INHIBITORS

Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer. The compounds of this invention have the structure (I) including stereoisomers, prodrugs and pharmaceutically accep

N-substituted 2,4-dialkoxy benzenesulfonamides and pharmaceutical compositions

The invention relates to new N-substituted benzenesulfonamides, the process for their preparation and their use. The compounds according to the invention correspond to the general formula (I): STR1 in which: n and m have values from 0 to 4; R3 and R4 represent in particular a lower alkyl radical; R1 and R2 represent in particular hydrogen atoms, linear or branched alkyl groups having from 1 to 4 carbon atoms; R5 represents particularly a hydrogen atom, a halogen, the NO2, NH2, or CF3 group; R6 and R7 represent in particular a hydrogen atom, an alkyl radical of 1 to 6 carbon atoms. The invention is useful in the preparation of tranquilizing or anxiolytic medicines.