3899-65-8

Basic information

• Product Name: BENZENE, 1-CHLORO-4,5-DIMETHOXY-2-NITRO-
• Synonyms: BENZENE, 1-CHLORO-4,5-DIMETHOXY-2-NITRO-;1-chloro-4,5-diMethoxy-2-nitrobenzene
• CAS NO: 3899-65-8
• Molecular Formula: C₈H₈ClNO₄
• Molecular Weight: 217.607
• Mol File: 3899-65-8.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 336.3 °C at 760 mmHg
• Flash Point: 157.2 °C
• Appearance: /
• Density: 1.349 g/cm³
• Vapor Pressure: 0.000221mmHg at 25°C
• Refractive Index: 1.545
• CAS DataBase Reference: BENZENE, 1-CHLORO-4,5-DIMETHOXY-2-NITRO-(CAS DataBase Reference)
• NIST Chemistry Reference: BENZENE, 1-CHLORO-4,5-DIMETHOXY-2-NITRO-(3899-65-8)
• EPA Substance Registry System: BENZENE, 1-CHLORO-4,5-DIMETHOXY-2-NITRO-(3899-65-8)

Safety Data

• Hazardous Substances Data: 3899-65-8(Hazardous Substances Data)

Usage

General Description

1-Chloro-4,5-dimethoxy-2-nitrobenzene is a chemical compound that falls under the category of organic compounds known as nitrobenzenes. Nitrobenzenes are compounds containing a nitrobenzene moiety, which consists of a benzene ring ortho, meta or para substituted with a nitro group. The detailed chemical classification of 1-Chloro-4,5-dimethoxy-2-nitrobenzene is Nitrobenzenes. BENZENE, 1-CHLORO-4,5-DIMETHOXY-2-NITRO- is known to be potentially toxic or harmful to the environment. Its applications are not widely documented, indicating that the compound might not be massively used in industry or synthetic processes.

InChI:InChI=1/C8H8ClNO4/c1-13-7-3-5(9)6(10(11)12)4-8(7)14-2/h3-4H,1-2H3

Upstream product

• 16766-27-1 4-chloro-1,2-dimethoxybenzene 
• 91-16-7 1,2-dimethoxybenzene 
• 16766-30-6 4-Chloroguaiacol 
• 37942-55-5 1-(4,5-Dimethoxy-2-nitrophenyl)-ethanol 
• 4998-07-6 4,5-dimethoxy-2-nitro-benzoic acid 
• 7697-37-2 nitric acid 

Downstream Products

• 5739-55-9 1-(3,4-Dimethoxy-phenylaethylamino)-2-nitro-4,5-dimethoxy-benzol 
• 4527-51-9 2-(4,5-dimethoxy-2-nitrophenylthio)acetic acid 
• 171084-55-2 N,N-dimethyl-3,4-dimethoxy-6-nitroaniline 
• 913837-98-6 ethyl 2-cyano-2-(4,5-dimethoxy-2-nitro-phenyl)-acetate 
• 14227-14-6 1,2,4-trimethoxy-5-nitrobenzene 
• 121641-88-1 5,6-dimethoxy-2-amino-3-carbethoxyindole 
• 76844-97-8 4-chloro-1,2-dihydroxy-5-nitrobenzene 
• 2989-85-7 2-(4,5-Dimethoxy-2-nitro-phenylsulfanyl)-acetamide 
• 4604-95-9 (4,5-Dimethoxy-2-nitro-benzenesulfonyl)-acetic acid methyl ester 
• 4527-52-0 (4,5-dimethoxy-2-nitro-benzenesulfonyl)-acetic acid 
• 2989-86-8 2-(4,5-Dimethoxy-2-nitro-phenylsulfanyl)-N-hydroxy-acetamide 
• 4527-26-8 (4,5-Dimethoxy-2-nitro-phenylsulfanyl)-acetic acid methyl ester 
• 55403-58-2 1-nitro-2,4,5-triethoxybenzene 
• 99360-06-2 1,2-diethoxy-4-chloro-5-nitro-benzene 

Relevant articles and documents

QUINAZOLINONE COMPOUNDS

New quinazolinone compounds are disclosed, as well as pharmaceutical compositions containing quinazolinones and methods for the treatment of diseases and conditions associated with mitochondrial dysfunction.

Inexpensive NaX (X = I, Br, Cl) as a halogen donor in the practical Ag/Cu-mediated decarboxylative halogenation of aryl carboxylic acids under aerobic conditions

Versatile and practical Ag/Cu-mediated decarboxylative halogenation between readily available aryl carboxylic acids and abundant NaX (X = I, Br, Cl) has been achieved under aerobic conditions in moderate to good yields. The halodecarboxylation is shown to be an effective strategy for S-containing heteroaromatic carboxylic acid and benzoic acids with nitro, chloro and methoxyl substituents at the ortho position. A gram-scale reaction and a three-step procedure to synthesize iniparib have been performed to evaluate the practicality of this protocol. A preliminary mechanistic investigation indicates that Cu plays a vital role and a radical pathway is involved in the transformation.

Decarboxylative Halogenation and Cyanation of Electron-Deficient Aryl Carboxylic Acids via Cu Mediator as Well as Electron-Rich Ones through Pd Catalyst under Aerobic Conditions

Simple strategies for decarboxylative functionalizations of electron-deficient benzoic acids via using Cu(I) as promoter and electron-rich ones by employing Pd(II) as catalyst under aerobic conditions have been established, which lead to smooth synthesis of aryl halides (-I, Br, and Cl) through the decarboxylative functionalization of benzoic acids with readily available halogen sources CuX (X = I, Br, Cl), and easy preparation of benzonitriles from decarboxylative cyanation of aryl carboxylic acids with nontoxic and low-cost K4Fe(CN)6 under an oxygen atmosphere for the first time.