478411-22-2

Upstream product

• 62023-62-5 allophenylnorstatine 
• 167678-46-8 3-acetoxy-2-methylbenzoyl chloride 

Downstream Products

• 478410-84-3 KNI-1317 
• 749905-01-9 (2S,3S)-2-Acetoxy-3-(3-acetoxy-2-methyl-benzoylamino)-4-phenyl-butyric acid 
• 1054648-28-0 acetic acid 3-{(1S,2S)-1-benzyl-3-[(4R)-5,5-dimethyl-4-(2-methyl-benzylcarbamoyl)-thiazolidin-3-yl]-2-hydroxy-3-oxo-propylcarbamoyl}-2-methyl-phenyl ester 

Relevant academic research and scientific papers

COMPOSITIONS COMPRISING AN HIV PROTEASE INHIBITOR

The present invention relates to pharmaceutical compositions comprising amorphous (4R)-N-allyl-3-{(2S,3S)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-phenylbutanoyl}-5,5-dimethyl-1,3-thiazolidine-4-carboxamide, or a pharmaceutically acceptable salt o

Therapeutic combinations

The present invention relates to methods for improving the pharmacokinetics of certain compounds useful as inhibitors of the HIV protease enzyme by inhibiting the enzyme activity of cytochrome P450. The present invention also relates to compositions compr

Therapeutic combinations

The present invention relates to methods for treating an HIV infection a mammal by administering to the mammal a therapeutically effective amount of a combination of compounds. The present invention also relates to compositions comprising certain compound

Methods of preparing compounds useful as protease inhibitors

The invention relates to methods of preparing compounds of formula (I), useful as inhibitors of the HIV protease enzyme. The present invention also relates to intermediate compounds useful in the preparation of compounds of formula (I).

METHODS OF PREPARING COMPOUNDS USEFUL AS PROTEASE INHIBITORS

The invention relates to methods of preparing compounds of formula (I) that are useful as inhibitors of the HIV protease enzyme. The present invention also relates to intermediate compounds useful in the preparation of compounds of formula (I).

HIV protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis

The present invention concerns processes for preparing compounds of formula (I-H), or a prodrug, pharmaceutically active metabolite, or pharmaceutically active salt or solvate thereof, which are useful as inhibitors of the HIV protease enzyme.

HIV protease inhibitors, compositions containing the same, their pharmaceutical uses, material for their synthesis

Compounds of the formula: where the formula variables are as defined herein, are disclosed that advantageously inhibit or block the biological activity of the HIV protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with the HIV virus. Intermediates and synthetic methods for preparing such compounds are also described.