1677-29-8

Usage

Uses

Used in Coordination Chemistry:
N,N''-BIS-(4-FLUORO-PHENYL)-MALONAMIDE serves as a ligand in coordination chemistry, facilitating the formation of complexes with metal ions. Its structural design allows for versatile interactions, making it a valuable component in the synthesis of new coordination compounds.
Used in Catalysis:
The ability of N,N''-BIS-(4-FLUORO-PHENYL)-MALONAMIDE to form stable complexes with metal cations positions it as a potential catalyst or catalyst precursor in various chemical reactions. Its use can enhance the efficiency and selectivity of catalytic processes.
Used in Extraction and Separation Processes:
In the realm of extraction and separation techniques, N,N''-BIS-(4-FLUORO-PHENYL)-MALONAMIDE can be utilized to selectively bind with certain metal ions. This selective binding property is advantageous for processes that require the separation or purification of metal-containing compounds.
Used in Pharmaceutical Applications:
Given its complex-forming capabilities, N,N''-BIS-(4-FLUORO-PHENYL)-MALONAMIDE holds potential in the pharmaceutical industry. It may be employed in the development of new drugs or as a component in drug delivery systems, targeting specific metal ion interactions relevant to therapeutic effects.
Used in Materials Science:
N,N''-BIS-(4-FLUORO-PHENYL)-MALONAMIDE's interaction with metal ions can also be leveraged in materials science to create new materials with tailored properties. This could include the development of advanced catalysts, sensors, or materials with specific electronic or optical characteristics.
Used in Environmental Remediation:
N,N''-BIS-(4-FLUORO-PHENYL)-MALONAMIDE's metal-binding properties can be applied in environmental remediation efforts, particularly for the treatment of water or soil contaminated with heavy metals. Its use could facilitate the extraction and removal of these contaminants, aiding in the cleanup of polluted environments.

Upstream product

• 371-40-4 4-fluoroaniline 
• 105-53-3 diethyl malonate 
• 108-59-8 malonic acid dimethyl ester 

Downstream Products

• 1677-37-8 6-fluoro-4-hydroxy-1H-quinolin-2-one 
• 1614221-71-4 3,3-dibenzyl-6-fluoro-4-hydroxy-3,4-dihydro-1H-quinolin-2-one 
• 1614221-49-6 3,3-dibenzyl-6-fluoro-1H-quinoline-2,4-dione 
• 1309870-85-6 C₁₅H₉FIN₃O₂ 
• 1309870-84-5 C₁₆H₉F₄N₃O₂ 
• 1309870-83-4 C₁₅H₉ClFN₃O₂ 
• 1309870-81-2 C₁₅H₉BrFN₃O₂ 
• 1309870-80-1 C₁₅H₉ClFN₃O₂ 
• 1234896-95-7 C₁₅H₉FN₄O₄ 
• 1234896-94-6 C₁₆H₉FN₄O₂ 

Relevant academic research and scientific papers

Synthesis of symmetrically substituted 3,3-dibenzyl-4-hydroxy-3,4-dihydro- 1H-quinolin-2-ones, as novel quinoline derivatives with antibacterial activity

A novel series of symmetrically substituted 3,3-dibenzyl-4-hydroxy-3,4- dihydro-1H-quinolin-2-ones was synthesized and tested as antimicrobials. The minimum inhibitory concentration (MIC) values of the most active heterocycles were slightly higher than those exhibited by levofloxacin, employed as comparator. Structural factors affecting the activity were explored along three diversification points, including the substituents of the aromatic rings of the 3-benzyl moieties, as well as the functionalization of both, the homocyclic ring of the heterocycle and the quinolonic nitrogen atom. 6-Chloro and 3,3-bis(4′-chlorobenzyl) derivatives showed the lower MIC values. Optimally substituted heterocycles were synthesized, which exhibited enhanced activity.

A study of Solvatochromism in diazonium coupling products of 6-flouro 4-hydroxyl-2-quinolone

6-flouro 4-hydroxyl-2-quinolone was synthesized from cyclocondensation of corresponding dianilide and subsequently used as a potent coupling component with some diazotized aromatic amines. The prepared azo dyes were characterized by UV-vis, FT-IR, 1

Synthesis of 6-chloro and 6-fluoro-4-hydroxyl-2-quinolone and their azo disperse dyes

In this study, 6-chloro-4-hydroxy-2-quinolone and 6-flouro-4-hydroxy-2-quinolone were synthesized from corresponding dianilides. These compounds were coupled with some diazotized aromatic amines to give the corresponding azo disperse dyes. The structures

MODIFIED MALONATE DERIVATIVES

The present invention relates to a novel class of modified malonate derivatives. The modified malonate compounds can be used to treat cancer. The modified malonate compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention may also be useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases. The present invention further provides pharmaceutical compositions comprising the modified malonate derivatives and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of the modified malonate derivatives in vivo.