412336-41-5

Upstream product

• 5900-58-3 2-amino-4-chloro-benzoic acid methyl ester 
• 1071-46-1 hydrogen ethyl malonate 
• 95-79-4 5-chloro-2-methyl-benzenamine 
• 5900-56-1 2-acetylamino-4-chlorobenzoic acid 
• 5900-55-0 N-(5-chloro-2-methylphenyl)acetamide 
• 89-59-8 4-chloro-2-nitrotoluene 
• 89-77-0 2-Amino-4-chlorobenzoic acid 
• 36239-09-5 ethyl chlorocarbonylacetate 
• 105-53-3 diethyl malonate 

Downstream Products

• 1677-49-2 2,4,7-trichloroquinoline 

Relevant academic research and scientific papers

4-hydroxy-2-quinolones 199*. Use of N,N'-dicyclohexylcarbodiimide in the synthesis of ethyl 4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylates

A novel method has been developed for the synthesis of 4-hydroxy-2-oxo-1,2- dihydroquinoline-3-carboxylic acids esters based on the use of monoethyl malonate as an acylating agent in the presence of N,N'-dicyclohexylcarbodiimide and characterized by high yields and purity for the final products. Practical recommendations are given for the removal of specific admixtures.

4-Hydroxy-2-quinolones. 90.* Synthesis and antitubercular activity of 4-methyl-2-thiazolylamides of halo-substituted 4-hydroxy-2-oxo-1,2-dihydro-3- quinolinecarboxylic acids

Several variants were studied for the synthesis of esters of halogen derivatives of 4-hydroxy-2-oxo-1,2-dihydro-3-quinolinecarboxylic acids, whose reaction with 2-amino-4-methylthiazole gives the corresponding hetarylamides. Results are given for a study of the antitubercular activity of these products. 2006 Springer Science+Business Media, Inc.