5900-56-1

Usage

Uses

Used in Pharmaceutical Industry:
2-(Acetylamino)-4-chlorobenzoic acid is used as an intermediate in the synthesis of anti-inflammatory and analgesic drugs. Its chemical structure allows for the development of medications that can effectively reduce inflammation and alleviate pain.
Used in Agricultural Industry:
2-(ACETYLAMINO)-4-CHLOROBENZOIC ACID is also utilized in the production of herbicides and fungicides. 2-(Acetylamino)-4-chlorobenzoic acid contributes to the formulation of agricultural chemicals that help control the growth of unwanted plants and fungi, thereby protecting crops and enhancing agricultural productivity.

InChI:InChI=1/C9H8ClNO3/c1-5(12)11-8-4-6(10)2-3-7(8)9(13)14/h2-4H,1H3,(H,11,12)(H,13,14)

Upstream product

• 5900-55-0 N-(5-chloro-2-methylphenyl)acetamide 
• 708-73-6 7-chloro-2-methyl-4H-3,1-benzoxazin-4-one 
• 7487-88-9 magnesium sulfate 
• 108-24-7 acetic anhydride 
• 89-77-0 2-Amino-4-chlorobenzoic acid 
• 89-59-8 4-chloro-2-nitrotoluene 
• 95-79-4 5-chloro-2-methyl-benzenamine 
• 75-36-5 acetyl chloride 
• 32833-96-8 N,N-dimethyloxamic acid 
• 588-07-8 3-Chloroacetanilide 

Downstream Products

• 112887-28-2 2-(acetylamino)-4-chloro-5-nitrobenzoic acid 
• 112887-27-1 2-amino-4-(dimethylamino)-5-nitrobenzoic acid 
• 112887-29-3 2-(acetylamino)-4-(dimethylamino)-5-nitrobenzoic acid 
• 170798-77-3 7-(dimethylamino)-6-nitro-2-phenyl-4H-3,1-benzoxazin-4-one 
• 170798-70-6 5-amino-2-(benzoylamino)-N-<(4-benzyl-2-morpholinyl)methyl>-4-(dimethylamino)benzamide 
• 170798-69-3 2-(benzoylamino)-N-<(4-benzyl-2-morpholinyl)methyl>-4-(dimethylamino)-5-nitrobenzamide 
• 50-84-0 2,4 dichlorobenzoic acid 
• 1677-49-2 2,4,7-trichloroquinoline 
• 412336-41-5 2-(2-ethoxycarbonyl-acetylamino)-4-chloro-benzoic acid methyl ester 
• 149231-52-7 4-chloroanthranilic acid hydrochloride 
• 7012-88-6 7-chloro-2-methylquinazolin-4(3H)-one 
• 127033-30-1 (E)-7-chloro-2-styrylquinazolin-4(3H)-one 
• 89-77-0 2-Amino-4-chlorobenzoic acid 
• 5900-58-3 2-amino-4-chloro-benzoic acid methyl ester 

Relevant academic research and scientific papers

Structure-Based Target-Specific Screening Leads to Small-Molecule CaMKII Inhibitors

Target-specific scoring methods are more commonly used to identify small-molecule inhibitors among compounds docked to a target of interest. Top candidates that emerge from these methods have rarely been tested for activity and specificity across a family

Palladium-catalyzed C-H bond carboxylation of acetanilides: An efficient usage of N,N-dimethyloxamic acid as the carboxylate source

N,N-Dimethyloxamic acid can be successfully employed as a carboxylate precursor in the palladium-catalyzed direct C-H carboxylation of acetanilides. The reaction proceeds smoothly under mild conditions over a broad range of substrates with high functional group tolerance, affording substituted N-acyl anthranilic acids in moderate to high yields.

Design, synthesis and anticonvulsant evaluation of N-(benzo[d]thiazol-2- ylcarbamoyl)-2-methyl-4-oxoquinazoline-3(4H)-carbothioamide derivatives: A hybrid pharmacophore approach

Novel N-(benzo[d]thiazol-2-ylcarbamoyl)-2-methyl-4-oxoquinazoline-3(4H)- carbothioamide derivatives were synthesized and evaluation of their anticonvulsant effects was done using various models of experimental epilepsy. Initial anticonvulsant activities of the compounds were investigated using intraperitoneal (i.p.) maximal electroshock shock (MES), subcutaneous pentylenetetrazole (scPTZ) seizure models in mice. The quantitative assessment after oral administration in rats showed that the most active was 2-methyl-4-oxo-N-(6-(trifluoromethoxy)benzo[d]thiazol-2-ylcarbamoyl) quinazoline-3(4H)-carbothioamide (SA 24) with ED50 values of 82.5 μmol/kg (MES) and 510.5 μmol/kg (scPTZ). This molecule was more potent than phenytoin and ethosuximide which were used as reference antiepileptic drugs. To explain the possible mechanism for anticonvulsant action, some of the selected active compounds were subjected to GABA (γ-amino butyric acid) assay and AMPA ((S)-2-amino-3-(3-hydroxyl-5-methyl-4-isoxazolyl) propionic acid) induced seizure test.

ONE-POT REDUCTIVE ACETAMIDATION OF ARYL NITRO COMPOUNDS

The present invention provides a method for the reductive acetamidation of an aryl nitro compound by reacting a substituted acid with an aryl nitro compound and adding a catalytic amount of a base with the substituted acid and the aryl nitro compound to form an acetamidation aryl nitro compound. The acetamidation aryl nitro compound is then purified.

1H and 13C NMR spectral studies of some 4H-3,1-benzoxazin-4-ones and their 2-acylaminobenzoic acid precursors

The 1H and 13C NMR spectra of twelve 4H-3,1-benzoxazine-4-ones and of their acylaminobenzoic acid precursors are presented. Differentiation between these two series of compounds is best achieved through the characteristic JCH coupling interactions in the high frequency carbonyl region. Some 4H-pyrido[2,3-d][1,3]oxazin-4-ones have also been studied and some earlier literature assignments revised.