167764-27-4Relevant academic research and scientific papers
Solid-Phase Photochemical C-S Bond Cleavage Of Thioethers - A New Approach To The Solid-Phase Production Of Non-Peptide Molecules.
Sucholeiki, Irving
, p. 7307 - 7310 (1994)
Thioethers can readily be used as a method for attachment of organic molecules to solid supports and can undergo light induced heterogeneous C-S bond cleavage upon irradiation with 350 nm light.
Method for preparing and selecting pharmaceutically useful sulfur-bridged bi- and triaromatic ring compounds from a structurally diverse universal library
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, (2008/06/13)
Methods for rapidly generating large rationally designed libraries of structurally-diverse small molecular weight compounds using a multicombinatorial approach. Also disclosed are compounds of the formula
Solid-Phase Synthetic Methods in Combinatorial Chemistry
Sucholeiki, Irving
, p. 618 - 630 (2007/10/03)
The gel-phase carbon NMR spectra of various polymer supports are evaluated as to their suitability in the production of non-peptide combinatorial libraries. The solid-phase synthesis of biphenyls as scaffolds for the production of combinatorial libraries is also described. Both substituted and unsubstituted trialkylphenyltins were shown to undergo heterogenous palladium-catalyzed Stille coupling with aryl electrophiles to give after photolytic cleavage using the NpSSMpact linker biphenyls containing no residual amide, carboxylic acid, or alcohol appendages.
