167764-29-6Relevant academic research and scientific papers
Solid-Phase Synthetic Methods in Combinatorial Chemistry
Sucholeiki, Irving
, p. 618 - 630 (2007/10/03)
The gel-phase carbon NMR spectra of various polymer supports are evaluated as to their suitability in the production of non-peptide combinatorial libraries. The solid-phase synthesis of biphenyls as scaffolds for the production of combinatorial libraries is also described. Both substituted and unsubstituted trialkylphenyltins were shown to undergo heterogenous palladium-catalyzed Stille coupling with aryl electrophiles to give after photolytic cleavage using the NpSSMpact linker biphenyls containing no residual amide, carboxylic acid, or alcohol appendages.
