167765-43-7Relevant academic research and scientific papers
LACTOL DERIVATIVES, THEIR PRODUCTION AND USE
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, (2008/06/13)
The present invention provides novel compound of the formulas (Ia) or (I): STR1 wherein Q is one or two amino acid residues which may be substituted; R 3 is a carboxyl group which may be esterified or an acyl group; A is an alkylene group; B is hydrogen or an alkyl group which may be substituted or an acyl group; or a salt thereof; STR2 wherein R 1 and R 2 may be the same or different and each is hydrogen or a hydrocarbon residue which may be substituted; R 3, A and B have the same definitions as those shown above; m and n each is 0 or 1; provided that where both m and n are both equal to 0, R 3 is a carboxyl group which may be esterified or an acyl group having not less than 7 carbon atoms; or a salt thereof.The compound (Ia) or (I) shows cathepsin L inhibitory and bone resorption inhibitory activities and are useful as a prophylactic/therapeutic agent for osteoporosis.
