16802-73-6

Usage

InChI:InChI=1/C10H10N2OS/c1-2-14-10-11-8-6-4-3-5-7(8)9(13)12-10/h3-6H,2H2,1H3,(H,11,12,13)

Upstream product

• 62-53-3 aniline 
• 80947-13-3 N¹-Aethoxycarbonyl-N²-phenyl-5-aethylisothioharnstoff 
• 64-67-5 diethyl sulfate 
• 13906-09-7 2-mercapto-3H-quinazolin-4-one 
• 118-92-3 anthranilic acid 
• 74-96-4 ethyl bromide 
• 13906-09-7 2-thioxo-2,3-dihydro-1H-quinazolin-4-one 
• 75-03-6 ethyl iodide 
• 24774-92-3 N¹-Aethoxycarbonyl-N²-phenylthioharnstoff 

Downstream Products

• 129663-89-4 2-(4-phenylpiperazin-1-yl)quinazolin-4(3H)-one 
• 86-96-4 quinazoline-2,4-diol 
• 122009-54-5 2-(4-allyl-1-piperazinyl)-4-pentyloxyquinazoline 
• 58803-78-4 4-chloro-2-ethylsulfanylquinazoline 
• 39213-14-4 2-(4-methylpiperazin-1-yl)-4-phenoxyquinazoline 
• 129112-57-8 2-(4-Benzyl-piperazin-1-yl)-4-phenoxy-quinazoline 
• 129112-39-6 4-(3-Methoxy-phenoxy)-2-(4-methyl-piperazin-1-yl)-quinazoline 
• 129112-56-7 2-(4-Allyl-piperazin-1-yl)-4-phenoxy-quinazoline 
• 129112-55-6 4-Phenoxy-2-(4-propyl-1-piperazinyl)quinazoline 
• 129112-54-5 2-(4-Ethyl-piperazin-1-yl)-4-phenoxy-quinazoline 
• 129112-67-0 2-(4-Methyl-piperazin-1-yl)-4-p-tolyloxy-quinazoline 
• 129664-02-4 4-Pentyloxy-2-(4-pentyl-piperazin-1-yl)-quinazoline; compound with (E)-but-2-enedioic acid 
• 129664-22-8 2-[4-(2-Methyl-allyl)-piperazin-1-yl]-4-pentyloxy-quinazoline; compound with (E)-but-2-enedioic acid 
• 129664-21-7 2-[((E)-4-But-2-enyl)-piperazin-1-yl]-4-pentyloxy-quinazoline; compound with (E)-but-2-enedioic acid 

Relevant academic research and scientific papers

Phase-transfer catalyzed alkylation and cycloalkylation of 2-mercaptoquinazolin-4(3H)-one

Solid/liquid phase-transfer catalyzed alkylation of 2-mercaptoquinazolin- 4(3H)-one at 25°C by different organohalogen compounds in the presence of tetrabutylammonium bromide as a catalyst underwent, exclusively, S-monoalkylation or S- and N-, di-, or cyc

A green and facile synthesis of 2-alkylsulfanyl-3H-quinazolin-4-one

Reaction of 2-thioquinazolinone (1) with various alkylating agents like dimethyl sulphate, diethyl sulphate and benzyl chloride in the presence of K2CO3 as a mild base, by a simple physical grinding, microwave irradiation and PEG-600 under solvent-free conditions for 10-15 min at room temperature, followed by processing, gave respectively 2-methylsulfanyl-3H-quinazolin-4-one (2a, i.e., R = CH3), 2-ethylsulfanyl-3H-quinazolin-4-one (2b, i.e., R = C2H5) and 2-benzyl sulfanyl-3H-quinazolin-4-one (2c, i.e., R = PhCH2Cl). It appears from this study that green syntheses such as solid phase synthesis (physical grinding) and microwave irradiation gives better yields, quality and in less reaction time the products over conventional methods involving green solvents like ethanol, PEG-600 etc. The entire sequences of reactions have been carried out using eco-friendly solvents and green conditions.

QUINAZOLINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF DIABETES AND OBESITY

The present invention relates to novel quinazoline derivatives effective in lowering blood glucose level and body weight, and a medicine for treatment and/or prevention of diabetes and/or obesity, which comprises the compound as an active ingredient.

SYNTHESIS OF 2-ALKYLTHIOQUINAZOL-4-ONES

Alkylation of 2-thioxoquinazol-4-one by different alkylating agents was studied, and it was found that the reaction proceeds at the exocyclic sulfur atom with the formation of 2-alkylthioquinazol-4-ones.

SYNTHESIS AND ALKYLATION OF 2-MERCAPTO-4-QUINAZOLONE AND THE FUNGICIDAL ACTIVITIES OF THE COMPOUNDS OBTAINED

A convenient method of obtaining 2-mercapto-4-quinazolone has been developed and the alkylation of its ambidentate anions has been studied.It has been found that they exhibit a dual reactivity in alkylation reactions.It has been shown that alkylated 2-mercapto-4-quinazolones possess a moderate fungicidal activity.

Herstellung Kondensierter 2-Alkylthio-4-hydroxypyrimidine

Aromatic amines and alkoxycarbonyl isothiokyanate give thioureas 7.These are alkylated to S-alkylisothioureas 8, which upon heating lose alcohol to give 2-alkylthio-4-hydroxypyrimidines.