16819-79-7

Usage

Uses

Used in Perfumery and Cosmetics Industry:
2'-Ethylpropiophenone is used as a fragrance ingredient for its sweet, floral odor, enhancing the sensory experience of perfumes and cosmetics. Its pleasant aroma makes it a valuable addition to these products, contributing to their appeal and consumer satisfaction.
Used in Pharmaceutical Industry:
In the pharmaceutical sector, 2'-Ethylpropiophenone serves as a key component in the production of various medications. Its chemical properties allow it to be integrated into drug formulations, potentially aiding in the development of new therapeutic agents.
Used as a Flavoring Agent in Food Industry:
2'-Ethylpropiophenone is also utilized in the food industry as a flavoring agent. Its distinctive sweet scent can be incorporated into food products to enhance their taste and aroma, providing a more enjoyable culinary experience for consumers.
Safety Considerations:

Upstream product

• 462-06-6 fluorobenzene 
• 96-22-0 pentan-3-one 
• 108-86-1 bromobenzene 
• 609-65-4 o-chlorobenzoyl chloride 
• 1973-22-4 1-bromo-2-ethylbenzene 
• 67541-89-3 1-(2-ethylphenyl)propanol 

Downstream Products

• 1126518-91-9 2-bromo-1-(2-ethylphenyl)propan-1-one 
• 56839-43-1 eperisone hydrochloride 
• 67541-89-3 1-(2-ethylphenyl)propanol 

Relevant academic research and scientific papers

Preparation method of Eperisone hydrochloride impurity F

The invention provides a preparation method of Eperisone hydrochloride impurity F, which comprises the following steps: 2-bromoethylbenzene is used as a raw material, 1- (2-ethylphenyl) propanol is obtained through Grignard reaction, 2-ethyl propiophenone is obtained through oxidation reaction, and finally the Eperisone hydrochloride impurity F is obtained through Mannich reaction of the 2-ethyl propiophenone, paraformaldehyde and piperidine hydrochloride by a one-pot method. The structure of the Eperisone hydrochloride impurity F is shown as a formula (I), the purity of theEperisone hydrochloride impurity F obtained by adopting the technical scheme provided by the invention can reach 99%, and the Eperisone hydrochloride impurity F can be used as a reference substance for experimental research.

An efficient MnCl2-catalyzed tandem acylation-cross-coupling reaction of o-halobenzoyl chloride with diorganyl magnesium compounds

An efficient tandem cross-coupling reaction of o-chlorobenzoyl chloride with dialkyl and diaryl magnesium compounds in the presence of manganese (II) chloride was developed, which proceeds in good yield under mild conditions. Copyright

Regioselectivity of the Base-Induced Ring Cleavage of 1-Oxygenated Derivatives of Cyclobutabenzene

Oxy anions 3 generated from 1,2-dihydrocyclobutabenzen-1-ones 1 through addition of a charged nucleophile or from 1-hydroxy-1,2-dihydrocyclobutabenzenes 2 by deprotonation with base lead to stable products through distal and/or proximal cleavage of the strained four-membered ring via benzyl carbanion 4 and/or aryl carbanion 5. A systematic study of this process reveals the relative stability of the two isomeric carbanions 4 and 5 as a key factor in determining the course of the ring-cleavage reaction. While benzyl carbanions 4 can be trapped with carbon electrophiles, attempts at trapping aryl carbanions 5 with electrophiles other than H+ failed. In protic solvents, the magnesium salt of the tertiary alcohol 2 shows an increased rate of proximal cleavage as compared to its alkali salts. From this, we conclude that, in contrast to benzyl carbanions 4, free aryl carbanions 5 are of transient existence only. Proximal C,C-bond cleavage seems to occur either through protonation of 5 from a fast, reversible equilibrium 3?5 in which 3 strongly predominates, or in protic solvents possibly even through a rate-limiting protonation of 3 at the aromatic C-atom, bypassing free anion 5 altogether. Thus, additional factors other than just the relative stability of isomeric carbanions 4 and 5 are of importance in determining the regiochemistry of the base-induced C,C-bond cleavage in ketones 1 and in alcohols 2.