1683-85-8

Usage

Uses

Used in Pharmaceutical Industry:
2-Pyrimidinamine, 5-fluoro(9CI) is used as a pharmaceutical intermediate for the development of new drugs. Its unique structure and properties may contribute to the discovery of novel therapeutic agents with improved efficacy and selectivity.
Used in Agrochemical Industry:
2-Pyrimidinamine, 5-fluoro(9CI) is used as a building block in the synthesis of agrochemicals, such as pesticides and herbicides. Its incorporation into these compounds may enhance their effectiveness in controlling pests and weeds, while minimizing environmental impact.
Used in Materials Science:
2-Pyrimidinamine, 5-fluoro(9CI) is used as a component in the development of advanced materials with specific properties. Its unique structure may contribute to the creation of materials with improved performance in various applications, such as electronics, sensors, and energy storage systems.

InChI:InChI=1/C4H4FN3/c5-3-1-7-4(6)8-2-3/h1-2H,(H2,6,7,8)

Upstream product

• 50-01-1 guanidine hydrochloride 
• 128229-03-8 (Z)-(2,3,3-trifluoro-l-propenyl)trimethylammonium iodide 
• 109-89-7 diethylamine 
• 62802-42-0 2-chloro-5-fluoropyrimidine 

Downstream Products

• 1354819-21-8 N-(2,4-dimethoxybenzyl)-5-fluoropyrimidin-2-amine 
• 1354819-16-1 5-chloro-2,4-difluoro-N-(5-fluoropyrimidin-2-yl)benzenesulfonamide 

Relevant academic research and scientific papers

Compounds for treating spinal muscular atrophy

Provided herein are compounds, compositions thereof and uses therewith for treating spinal muscular atrophy. In a specific embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN2 into mRNA that is transcribed from the SMN2 gene. In another specific embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN1 into mRNA that is transcribed from the SMN1 gene. In yet another embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN1 and SMN2 into mRNA that is transcribed from the SMN1 and SMN2 genes, respectively.

Peptide deformylase inhibitors

The present invention relates to a compound of Formula (I): or a pharmaceutically acceptable salt thereof, corresponding pharmaceutical compositions, compound preparation and treatment methods directed to bacterial infections and inhibition of bacterial peptide deformylase (PDF) activity.

PEPTIDE DEFORMYLASE INHIBITORS

The present invention relates to a compound of Formula (I): or a pharmaceutically acceptable salt thereof, corresponding pharmaceutical compositions, compound preparation and treatment methods directed to bacterial infections and inhi-bition of bacterial peptide deformylase (PDF) activity

Reactions of β-Fluorovinamidinium Salt with Bifunctional Hetero Nucleophiles. A New Synthetic Route to Fluorinated Heterocycles

β-Fluorovinamidium salt (2), readily prepared from N-(2,3,3-trifluoro-1-propenyl) trimethyl-ammonium iodide (1) and diethylamine, reacted with bifunctional hetero nucleophiles such as amidine and guanidine hydrochlorides in the presence of a base to afford regiospecifically monofluoronated pyrimidines 4 in good yields.The one-pot procedure starting from 1 was applicable for synthesizing heterocyclic compounds 4 in almost comparable yields.

Reactions of 1-Substituted-polyfluoro-1-propenyl p-Toluenesulfonates with Bifunctional Nitrogen Nucleophiles. A New Expedient Access to Monofluorinated Nitrogen Heterocycles

1-Substituted-2,3,3-trifluoro-1-propenyl p-toluenesulfonates, readily available by the alkylation or arylation of 2,3,3-trifluoro-1-tosyloxy-1-propenyllithium or -zinc reagent, reacted smoothly with amidine or hydrazine derivatives at 70 deg C for 1h to give the corresponding 5-fluoropyrimidine or 4-fluoropyrazole compounds, respectively, in moderate to excellent yields.