1685-84-3Relevant academic research and scientific papers
Enzymatic resolution of α-tetralols by CALB-catalyzed acetylation
Ferraz, Helena M.C.,Bianco, Graziela G.,Teixeira, Carla C.,Andrade, Leandro H.,Porto, Andre L.M.
, p. 1070 - 1076 (2007)
A series of homochiral α-tetralols, as well as their respective acetates, has been obtained by esterification of racemic tetralols, using Candida antarctica lipase (CALB-Novozym 435) as the biocatalyst. This enzyme is shown to be highly efficie
Friedel-crafts acylation reactions using esters
Chavan, Subhash P.,Garai, Sumanta,Dutta, Achintya Kumar,Pal, Sourav
supporting information, p. 6841 - 6845 (2013/02/22)
Intermolecular and intramolecular Friedel-Crafts acylation reactions of various aliphatic and aromatic esters at room temperature with the use of very simple reagents and activating groups in are described. The products were obtained in good yield (60-85 %). The detailed mechanistic pathway was studied by DFT calculations and supported by experimental evidence. Copyright
(+)- And (-)-mutisianthol: First total synthesis, absolute configuration, and antitumor activity
Bianco, Graziela G.,Ferraz, Helena M. C.,Costas, Arinice M.,Costa-Lotufo, Leticia V.,Pessoa, Claudia,De Moraes, Manoel O.,Schreins, Marcus G.,Pfaltz, Andreas,Silva Jr., Luiz F.
supporting information; experimental part, p. 2561 - 2566 (2009/09/25)
The first synthesis of the natural product (+)-mutisianthol was accomplished in 11 steps and in 21% overall yield from 2-methylanisole. The synthesis of its enantiomer was also performed in a similar overall yield. The absolute configuration of the sesquiterpene (+)-mutisianthol was assigned as (15,37?). Key steps in the route are the asymmetric hydrogenation of a nonfunctionalized olefin using chiral iridium catalysts and the ring contraction of 1,2-dihydronaphthalenes using thallium(III) or iodine(III). The target molecules show moderate activity against the human tumor cell lines SF-295, HCT-8, and MDA-MB-435.
4,5-DIHYDRONAPHTHO [1,2-b] THIOPHENE DERIVATIVE
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Page/Page column 15, (2010/11/08)
A 4,5-dihydronaphtho[1,2-b]thiophene derivative expressed by the formula: (wherein R1 is a C1 to C10 1-hydroxyalkyl group or a C1 to C10 acyl group, and R2 and R3 separately substitute in the 6-, 7-, 8-, or 9-positions, and are each independently a hydrogen atom, a halogen atom, a C1 to C10 alkyl group, a hydroxy group, a C1 to C10 alkoxy group, a C1 to C5 alkenyloxy group, a C1 to C5 alkynyloxy group, a benzyloxy group, or the like, provided that when R1 is an acyl group and R2 is a hydrogen atom, then R3 is neither a hydrogen atom nor an acetyl group), or a pharmaceutically acceptable salt thereof. This is a novel compound that is effective in reducing triglyceride levels in the liver and reducing blood glucose levels.
Amines substituted with a dihydronaphthalenyl, chromenyl, or thiochromenyl group, an aryl or heteroaryl group and an alkyl group, having retinoid-like biological activity
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, (2008/06/13)
Compounds of the formula where the symbols are as defined in the specification, have retinoid agonist, antagonist or negative hormone-like biological activity.
Amines substituted with a dihydronaphthalenyl, chromenyl, or thiochromenyl group, an aryl or heteroaryl group and an alkyl group, having retinoid-like biological activity
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, (2008/06/13)
Compounds of the formula where the symbols are as defined in the specification, have retinoid agonist, antagonist or negative hormone-like biological activity.
Identification and synthesis of trinorcadalene phytoalexins formed by hibiscus cannabinus in honour of professor G. H. Neil towers 75th birthday
Bell, Alois A.,Stipanovic, Robert D.,Zhang, Jiuxu,Mace, Marshall E.,Reibenspies, Joseph H.
, p. 431 - 440 (2007/10/03)
Two trinorcadalene phytoalexins, hibiscanal (2,8-dihydroxy-4,7-dimethoxy-6-methyl-1-naph-thaldehyde) and o-hibiscanone (3,8-dimethyl-1,2-naphthoquinone), were isolated and identified from stem stele of kenaf (Hibiscus cannabinus) inoculated with the funga
A novel type of retinoic acid receptor antagonist: Synthesis and structure-activity relationships of heterocyclic ring-containing benzoic acid derivatives
Yoshimura,Nagai,Hibi,Kikuchi,Abe,Hida,Higashi,Yamanaka
, p. 3163 - 3173 (2007/10/02)
A new series of heterocyclic ring-containing benzoic acids was prepared, and the binding affinity and antagonism of its members against all-trans- retinoic acid were evaluated by in vitro assay systems using human promyelocytic leukemia (HL-60) cells. Structure-activity relationships indicated that both an N-substituted pyrrole or pyrazole (1-position) and a hydrophobic region, with these linked by a ring system, were indispensable for effective antagonism. Among the compounds evaluated, optimal antagonism was exhibited by 4-[4,5,7,8,9,10-hexahydro-7,7,10,-10-tetramethyl-1-(3- pyridylmethyl)anthra[1,2-b]pyrrol-3-yl]benzoic acid (31), 4-[4,5,7,8,9,10- hexahydro-7,7,10,10-tetramethyl-1-(3-pyridylmethyl)-5-thiaanthra[1,2- b]pyrrol-3-yl]benzoic acid (40), and 4-[4,5,7,8,9,10-hexahydro-7,7,10,10- tetramethyl-1-(3-pyridylmethyl)anthra[2,1-d]pyrazol-3-yl]benzoic acid (55), all of which possess a 3-pyridylmethyl group at the five-membered ring nitrogen atom.
An unusual C-C bond cleavage with chromium VI reagents: Oxidation of primary alcohols to ketones
Bijoy,Subba Rao
, p. 2701 - 2708 (2007/10/02)
Oxidation of 1-hydroxymethylindanes and 1-hydroxymethyltetralins with PDC or PCC in methylene chloride affords 1-indanones and 1-tetralones.
