16858-20-1

Usage

Uses

2-(4-Chlorophenyl)-6-methyl-4(3H)-pyrimidinone synthesis of 4-Pyrimidinols.

Upstream product

• 623-03-0 4-Cyanochlorobenzene 
• 14401-51-5 4-chlorobenzamidine hydrochloride 
• 105-45-3 acetoacetic acid methyl ester 

Downstream Products

• 66744-01-2 4-chloro-2-(4-chlorophenyl)-6-methylpyrimidine 
• 504400-11-7 2-{[2-(4-chlorophenyl)-6-methylpyrimidin-4-yl]amino}ethanol 

Relevant academic research and scientific papers

Discovery and biological evaluation of novel 4-amino-2-phenylpyrimidine derivatives as potent and orally active GPR119 agonists

Novel 4-amino-2-phenylpyrimidine derivatives were synthesized and evaluated as GPR119 agonists. Optimization of the substituents on the phenyl ring at the 2-position and the amino group at the 4-position led to the identification of 3,4-dihalogenated and

Synthesis and structure-activity relationship of 4-amino-2-phenylpyrimidine derivatives as a series of novel GPR119 agonists

Through preparation and examination of a series of novel 4-amino-2-phenylpyrimidine derivatives as agonists for GPR119, we identified 2-(4-bromophenyl)-6-methyl-N-[2-(1-oxidopyridin-3-yl)ethyl]pyrimidin-4-amine (9t). Compound 9t improved glucose tolerance in mice following oral administration and showed good pharmacokinetic profiles in rats.