168848-22-4

Basic information

• Product Name: 1-PHENYL-1'H-3,3'-DIMETHYL-5-DIMETHYL-5-HYDROXY[4,5']-BIPYRAZOL
• Synonyms: 1-PHENYL-1'H-3,3'-DIMETHYL-5-DIMETHYL-5-HYDROXY[4,5']-BIPYRAZOL;5,5'-dimethyl-2'-phenyl-2H,2'H-[3,4'-bipyrazole]-3'-ol
• CAS NO: 168848-22-4
• Molecular Formula: C₁₄H₁₄N₄O
• Molecular Weight: 254.29
• Mol File: 168848-22-4.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-PHENYL-1'H-3,3'-DIMETHYL-5-DIMETHYL-5-HYDROXY[4,5']-BIPYRAZOL(CAS DataBase Reference)
• NIST Chemistry Reference: 1-PHENYL-1'H-3,3'-DIMETHYL-5-DIMETHYL-5-HYDROXY[4,5']-BIPYRAZOL(168848-22-4)
• EPA Substance Registry System: 1-PHENYL-1'H-3,3'-DIMETHYL-5-DIMETHYL-5-HYDROXY[4,5']-BIPYRAZOL(168848-22-4)

Safety Data

• Hazardous Substances Data: 168848-22-4(Hazardous Substances Data)

Upstream product

• 100-63-0 phenylhydrazine 
• 54107-17-4 3-(2-phenylhydrazonoethyl)-4-hydroxy-6-methylpyrone-2-one 
• 771-03-9 3-acetyl-4-hydroxy-6-methyl-2H-pyran-2-one 
• 87100-61-6 1-(5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)butane-1,3-dione 

Relevant articles and documents

Synthesis of bipyrazoles and pyrazoloisoxazoles from 3-acetyl-4- hydroxy-6-methyl-2H-pyran-2-one

Phenylhydrazine or hydrazine react with 3-acetyl-4-hydroxy-6-methyl-2H- pyran-2-one (1) to give 4-acetoacetyl-3-methylpyrazolin-5-ones 4. The synthesis of bipyrazoles and pyrazoloisoxazoles from 4 are reported.

DIPYRAZOLES AS CENTRAL NERVOUS SYSTEM AGENTS

The present invention is directed to novel dipyrazole compounds compositions, or the pharmaceutically acceptable salts, stereoisomers, tautomers, or solvates thereof. Novel compounds include those of formula (I). The compounds of this invention modulate AMPA and NMDA receptor function, and therefore are useful as pharmaceutical agents, especially for the treatment of neuropsychiatric disorders.