87100-61-6

Usage

General Description

1-(5-Hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)butane-1,3-dione is a chemical compound with a molecular formula C14H14N2O3. It is a pyrazol-based compound that contains a butane-1,3-dione moiety. The compound has potential pharmaceutical significance and may exhibit a range of biological activities, including anti-inflammatory and analgesic properties. Its structure indicates that it is a derivative of pyrazol-5-ol and may be used in the production of pharmaceutical drugs or as a research chemical in the discovery of new therapeutic agents. However, further studies and research are needed to fully understand its medicinal potential and possible applications.

Upstream product

• 141-78-6 ethyl acetate 
• 37703-59-6 1-phenyl-3-methyl-4-acetylpyrazol-5-one 
• 54107-17-4 3-(2-phenylhydrazonoethyl)-4-hydroxy-6-methylpyrone-2-one 
• 100-63-0 phenylhydrazine 
• 771-03-9 3-acetyl-4-hydroxy-6-methyl-2H-pyran-2-one 
• 16807-48-0 3‐acetyl‐2‐hydroxy‐6‐methyl‐4H‐pyran‐4‐one 
• 89-25-8 edaravone 
• 54107-17-4 4-hydroxy-6-methyl-3-[(1E)-1-(2-phenylhydrazinylidene)ethyl]-2H-pyran-2-one 

Downstream Products

• 20062-41-3 3-methyl-s-triazolo<3,4-a>phthalazine 
• 37703-59-6 1-phenyl-3-methyl-4-acetylpyrazol-5-one 
• 64360-24-3 3,6-dimethyl-1-phenylpyrano[2,3-c]pyrazole-4(1H)-one 
• 168848-22-4 5-hydroxy-3-methyl-1-phenyl-4-(3-methylpyrazol-5-yl)pyrazole 
• 615-15-6 2-Methyl-1H-benzimidazole 
• 942-32-5 5-methyl-2-phenyl-2H-pyrazol-3-ol 
• 40966-84-5 2-methyl-9-hydroxy-4H-pyrido<1,2-a>pyrimidin-4-one 

Relevant academic research and scientific papers

One-Pot Three-Component Synthesis of Bispyrazole-thiazole-pyran-2-one Heterocyclic Hybrids

A new series of some interesting bispyrazole-thiazole-pyran-2-one heterocyclic hybrids has been efficiently synthesized via a one-pot catalyst-free three-component reaction of α-bromoacetylated pyran-2-one derivatives, thiosemicarbazide, and polysubstitut

1,4-Disubstituted-5-hydroxy-3-methylpyrazoles and some derived ring systems as cytotoxic and DNA binding agents. Synthesis, in vitro biological evaluation and in silico ADME study

Some novel polysubstituted pyrazoles, bipyrazoles and pyranopyrazoles, supported with various chemotherapeutically-active pharmacophores, were synthesized and biologically evaluated for their cytotoxic potential. Fifteen compounds (7–9, 12, 16, 17, 19, 21

Evaluation of heteroatom-rich derivatives as antitubercular agents with InhA inhibition properties

Two series of heterocyclic compounds derived from 3-acetyl-4-hydroxy-6-methyl-2H-pyran-2-one (DHA) and 2-acetylbutyrolactone have been synthesized and characterized. The compounds were evaluated for their activities against Mycobacterium tuberculosis stra

Synthesis, Anti-Inflammatory Activity, and COX-1/2 Inhibition Profile of Some Novel Non-Acidic Polysubstituted Pyrazoles and Pyrano[2,3-c]pyrazoles

The synthesis and evaluation of the anti-inflammatory activity of some structure hybrids comprising basically the 5-hydroxy-3-methyl-1-phenyl-4-substituted-1H-pyrazole scaffold directly linked to a variety of heterocycles and functionalities, or annulated

N-substituted [phenyl-pyrazolo]-oxazin-2-thiones as COX-LOX inhibitors: Influence of the replacement of the oxo -group with thioxo- group on the COX inhibition activity of N-substituted pyrazolo-oxazin-2-ones

Targeting to the synthesis of potent dual acting COX/LOX inhibitors as future anti-inflammatory drugs, we attempted a modification of the compounds based on docking analysis results. A substitution of the oxygen of the oxo-group of the oxazin-2-one ring b

Synthesis of some pyrano[2,3-c]pyrazoles

Synthetic methods have been developed to prepare pyrano[2,3-c]pyrazoles with various substituents at ring positions 1, 3, and 6. The 1H- and 13C-NMR properties of these products and their precursors are presented and discussed.

Synthesis and in silico biological activity evaluation of new N-substituted pyrazolo-oxazin-2-one systems

Cyclisation of pyrazolo-β-enaminones 3 readily obtained from 4-aceto acetyl pyrazol 2 with triphosgene led to the formation of N-substituted pyrazolo-1,3-oxazin-2-ones 4 in good yields. Estimation of pharmacotherapeutic potential, possible molecule mechan

C-C bond cleavage studies in bipyrazoles: A convenient synthesis of pyrazolo-5-ols

The treatment of 4-acetoacetyl derivative (3) of the pyrazoles with hydrazines in ethanol/HCl furnished a variety of bipyrazoles (4). However, when the reaction was performed in sodium acetate/acetic acid/ethanol, different hydrazines gave different products. Under these conditions an unexpected C-C bond cleavage was observed thus affording a convenient route for the formation of pyrazolo-5-ols (5 and 6).

Pyranopyrazoles III synthesis of 1H-pyrano[2,3-c]pyrazol-4-ones [1]

Various derivatives of title ring system were synthesized by Claisen condensation of 4 acetyl-5-hydroxypyrazoles with appropriate esters, followed by acid-catalyzed ring closure.

Synthesis and A1 and A(2A) adenosine binding activity of some pyrano[2,3-c]pyrazol-4-ones

A series of pyrano[2,3-c]pyrazol-4-ones was synthesized and evaluated for bovine brain adenosine A1 and A(2A) receptor binding affinity. Substituents at positions 5 and/or 6 were varied in order to define the structure-activity relationships in