16885-99-7

Basic information

• Product Name: 1H-Indole,1-(1-methylethyl)-(9CI)
• Synonyms: 1H-Indole,1-(1-methylethyl)-(9CI);1-isopropyl-1H-indole
• CAS NO: 16885-99-7
• Molecular Formula: C₁₁H₁₃N
• Molecular Weight: 159.22762
• Product Categories: ISOPROPYL
• Mol File: 16885-99-7.mol
• Article Data: 25

Chemical Properties

• Boiling Point: 58-60 °C(Press: 0.4 Torr)
• Appearance: /
• Density: 0.98±0.1 g/cm3(Predicted)
• CAS DataBase Reference: 1H-Indole,1-(1-methylethyl)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole,1-(1-methylethyl)-(9CI)(16885-99-7)
• EPA Substance Registry System: 1H-Indole,1-(1-methylethyl)-(9CI)(16885-99-7)

Safety Data

• Hazardous Substances Data: 16885-99-7(Hazardous Substances Data)

Usage

General Description

1H-Indole,1-(1-methylethyl)-(9CI) is a chemical compound with the molecular formula C11H13N. It is an indole derivative with a branched isopropyl group attached to the nitrogen atom. 1H-Indole,1-(1-methylethyl)-(9CI) is commonly used as a building block in the synthesis of various pharmaceuticals and agrochemicals. It is also used as an intermediate in the production of dyes, perfumes, and flavorings. Additionally, it has been studied for its potential biological activities, including its role in modulating serotonin receptors in the brain. Overall, 1H-Indole,1-(1-methylethyl)-(9CI) has a wide range of applications in the fields of medicine, agriculture, and chemistry.

Upstream product

• 120-72-9 indole 
• 75-26-3 isopropyl bromide 
• 496-15-1 1-indoline 
• 67-64-1 acetone 
• 187737-37-7 propene 
• 133437-43-1 3-(phenylsulfonyl)-1H-indole 
• 54491-43-9 3-phenylthioindole 
• 1243565-30-1 1-isopropyl-3-phenylsulfonylindole 
• 167479-15-4 1-isopropyl-1H-indole-2-carboxylic acid 
• 75-30-9 2-iodo-propane 

Downstream Products

• 1228761-29-2 N-(2-(4-butylpiperidin-1-yl)ethyl)-2-(1-isopropyl-1H-indol-3-yl)-2-oxoacetamide 
• 10487-31-7 1-isopropyl-1H-indole-2,3-dione 
• 151409-84-6 1-isopropyl-1H-indole-3-carbaldehyde 
• 949035-36-3 1-(1-isopropyl-1H-indol-3-yl)ethan-1-one 

Relevant articles and documents

Copper-Catalyzed Synthesis of Indolyl Benzo[b]carbazoles and Their Photoluminescence Property

A copper-catalyzed cascade cyclization of dihydroisobenzofurans with indoles for the rapid construction of indoly benzo[b]carbazoles has been reported, providing the desired products in moderate to good yields under mild conditions along with a broad substrate scope and good functional group tolerance. The photoluminescence property of these indoly benzo[b]carbazoles has also been investigated.

The palladium-catalyzed direct C3-cyanation of indoles using acetonitrile as the cyanide source

The ligand-free palladium-catalyzed C3-cyanation of indoles via direct C-H functionalization was achieved. This protocol, utilizing CH3CN as a green and readily available cyanide source, produced the desired products in moderate to good yields through transition-metal-catalyzed C-CN bond cleavage. This journal is

Synthesis and anticancer activity of novel bisindolylhydroxymaleimide derivatives with potent GSK-3 kinase inhibition

Synthesis and biological evaluation of a series of novel indole derivatives as anticancer agents is described. A bisindolylmaleimide template has been derived as a versatile pharmacophore with which to pursue chemical diversification. Starting from maleimide, the introduction of an oxygen to the headgroup (hydroxymaleimide) was initially investigated and the bioactivity assessed by screening of kinase inhibitory activity, identifying substituent derived selectivity. Extension of the hydroxymaleimide template to incorporate substitution of the indole nitrogens was next completed and assessed again by kinase inhibition identifying unique selectivity patterns with respect to GSK-3 and CDK kinases. Subsequently, the anticancer activity of bisindolylmaleimides were assessed using the NCI-60 cell screen, disclosing the discovery of growth inhibitory profiles towards a number of cell lines, such as SNB-75 CNS cancer, A498 and UO-31 renal, MDA MB435 melanoma and a panel of leukemia cell lines. The potential for selective kinase inhibition by modulation of this template is evident and will inform future selective clinical candidates.