168897-20-9

Basic information

• Product Name: 4-(2-PYRROLIDIN-1-YL-ETHYL)-ANILINE
• Synonyms: TIMTEC-BB SBB010841;ASINEX-REAG BAS 06706100;4-(2-PYRROLIDIN-1-YL-ETHYL)-ANILINE;4-(2-PYRROLIDIN-1-YL-ETHYL)-PHENYLAMINE;4-[2-(1-pyrrolidinyl)ethyl]aniline(SALTDATA: 2HCl);4-[2-(1-Pyrrolidinyl)ethyl]aniline
• CAS NO: 168897-20-9
• Molecular Formula: C₁₂H₁₈N₂
• Molecular Weight: 190.28
• Mol File: 168897-20-9.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 314.9 °C at 760 mmHg
• Flash Point: 129.2 °C
• Appearance: /
• Density: 1.055 g/cm³
• Vapor Pressure: 0.000453mmHg at 25°C
• Refractive Index: 1.58
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-(2-PYRROLIDIN-1-YL-ETHYL)-ANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-PYRROLIDIN-1-YL-ETHYL)-ANILINE(168897-20-9)
• EPA Substance Registry System: 4-(2-PYRROLIDIN-1-YL-ETHYL)-ANILINE(168897-20-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• HazardClass: IRRITANT
• Hazardous Substances Data: 168897-20-9(Hazardous Substances Data)

Usage

General Description

4-(2-Pyrrolidin-1-yl-ethyl)-aniline is a chemical compound that belongs to the class of aniline derivatives. It is often used as a precursor in the synthesis of various pharmaceuticals and organic compounds. The compound contains a pyrrolidinyl group and an aniline group, making it valuable in the production of drugs and other organic materials. It has potential applications in the field of medicine and chemical research due to its unique structure and reactivity. Additionally, it is important to handle this compound with caution, as it may have potential health hazards and should be used in a controlled environment by trained professionals.

InChI:InChI=1/C12H18N2/c13-12-5-3-11(4-6-12)7-10-14-8-1-2-9-14/h3-6H,1-2,7-10,13H2

Upstream product

• 103-63-9 1-phenyl-2-bromoethane 
• 926265-87-4 4-(2-oxo-2-pyrrolidin-1-ylethyl)aniline 
• 168897-19-6 4-(2-(1-pyrrolidinyl)ethyl)nitrobenzene 
• 5339-26-4 (4-nitrophenyl)ethyl bromide 
• 168897-62-9 2-(4-nitrophenyl)-1-(pyrrolidin-1-yl)ethan-1-one 
• 555-16-8 4-nitrobenzaldehdye 
• 51738-10-4 2,2-dibromo-1-(4-nitrophenyl)ethene 

Downstream Products

• 945104-59-6 3-(4-tert-butylphenyl)-5,5-dimethyl-1-[(2-{[4-(2-pyrrolidin-1-ylethyl)phenyl]amino}pyridin-4-yl)-methyl]imidazolidine-2,4-dione 
• 1567327-13-2 2-(4-(2-(pyrrolidin-1-yl)ethyl)phenyl)benzo[d][1,2]selenazol-3(2H)-one 
• 1093125-10-0 4-methyl-N-(4-(2-(pyrrolidin-1-yl)ethyl)phenyl)-3-(4-(3-(trifluoromethyl)phenyl)pyrimidin-2-ylamino)benzamide 
• 1027356-75-7 C₂₈H₃₅N₅O₃ 

Relevant articles and documents

Synthesis and biological evaluation of a new series of ebselen derivatives as glutathione peroxidase (GPx) mimics and cholinesterase inhibitors against Alzheimer's disease

A series of ebselen derivatives were designed, synthesised and evaluated as inhibitors of cholinesterases (ChEs) and glutathione peroxidase (GPx) mimics. Most of the compounds were found to be potent against AChEs and BuChE, compounds 5e and 5i, proved to be the most potent against AChE with IC50 values of 0.76 and 0.46 μM, respectively. Among these hybrids, most of the compounds were found to be good GPx mimics compare with ebselen. The selected compounds 5e and 5i were also used to determine the catalytic parameters and in vitro hydrogen peroxide scavenging activity. The results indicate that compounds 5e and 5i may be excellent multifunctional agents for the treatment of AD.

Synthesis and biological evaluation of new 4β-anilino-4′-O- demethyl-4-desoxypodophyllotoxin derivatives as potential antitumor agents

A series of new 4β-anilino-4′-O-demethyl-4-desoxypodophyllotoxin derivatives were prepared and evaluated for their cytotoxicities against four human cancer cell lines including KB, KB/VCR, A549 and 95D. Most compounds showed better growth-inhibition activities against tested cell lines than that of etoposide (VP-16). Preliminary structure-activity relationships (SARs) were concluded and it indicated that the side chains substituted at 4β position of podophyllotoxin significantly influenced the cytotoxic activity, especially for the drug resistance profile. In vivo studies of compound 26c on highly metastatic human lung cancer xenograft in nude mice showed that it can significantly inhibit tumor growth with administrating by oral route.

Novel Cyclic Urea Derivatives, Preparation Thereof and Pharmaceutical Use Thereof as Kinase Inhibitors

Compounds of formula (I): wherein Ra, Rb, R, X1 and X2 are as defined in the disclosure, pharmaceutical compositions comprising said compounds, processes for making and methods of using the same are provided.