168897-62-9

Basic information

• Product Name: Pyrrolidine, 1-[(4-nitrophenyl)acetyl]-
• CAS NO: 168897-62-9
• Molecular Formula: C12H14N2O3
• Molecular Weight: 234.255
• Mol File: 168897-62-9.mol

Chemical Properties

• CAS DataBase Reference: Pyrrolidine, 1-[(4-nitrophenyl)acetyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrrolidine, 1-[(4-nitrophenyl)acetyl]-(168897-62-9)
• EPA Substance Registry System: Pyrrolidine, 1-[(4-nitrophenyl)acetyl]-(168897-62-9)

Safety Data

• Hazardous Substances Data: 168897-62-9(Hazardous Substances Data)

Upstream product

• 123-75-1 pyrrolidine 
• 104-03-0 4-nitrobenzeneacetic acid 
• 555-16-8 4-nitrobenzaldehdye 
• 51738-10-4 2,2-dibromo-1-(4-nitrophenyl)ethene 
• 940-13-6 1-(2-bromoethynyl)-4-nitrobenzene 

Downstream Products

• 926265-87-4 4-(2-oxo-2-pyrrolidin-1-ylethyl)aniline 
• 168897-19-6 4-(2-(1-pyrrolidinyl)ethyl)nitrobenzene 
• 168897-20-9 4-(2-pyrrolidin-1-yl-ethyl)phenylamine 
• 104-03-0 4-nitrobenzeneacetic acid 

Relevant articles and documents

Synthesis of Novel Heterocycles by Amide Activation and Umpolung Cyclization

Herein, we report a metal-free synthesis of cyclic amidines, oxazines, and an oxazinone under mild conditions by electrophilic amide activation. This strategy features an unusual Umpolung cyclization mode and enables the smooth union of α-aryl amides and diverse alkylazides, effectively rerouting our previously reported α-amination transform.

Synthesis and biological evaluation of new 4β-anilino-4′-O- demethyl-4-desoxypodophyllotoxin derivatives as potential antitumor agents

A series of new 4β-anilino-4′-O-demethyl-4-desoxypodophyllotoxin derivatives were prepared and evaluated for their cytotoxicities against four human cancer cell lines including KB, KB/VCR, A549 and 95D. Most compounds showed better growth-inhibition activities against tested cell lines than that of etoposide (VP-16). Preliminary structure-activity relationships (SARs) were concluded and it indicated that the side chains substituted at 4β position of podophyllotoxin significantly influenced the cytotoxic activity, especially for the drug resistance profile. In vivo studies of compound 26c on highly metastatic human lung cancer xenograft in nude mice showed that it can significantly inhibit tumor growth with administrating by oral route.

Novel Cyclic Urea Derivatives, Preparation Thereof and Pharmaceutical Use Thereof as Kinase Inhibitors

Compounds of formula (I): wherein Ra, Rb, R, X1 and X2 are as defined in the disclosure, pharmaceutical compositions comprising said compounds, processes for making and methods of using the same are provided.

An efficient method for one-carbon elongation of aryl aldehydes via their dibromoalkene derivatives

Various aryl aldehydes were efficiently converted into one-carbon extended aryl acetamides or aryl acetic acids through the reaction of their dibromoalkene derivatives with pyrrolidine in the presence of water under very mild conditions.