169032-03-5 Usage
General Description
4-Hydroxy-2,3-dihydro-1H-indene-2-carboxylic acid, also known as droxidopa, is a synthetic amino acid precursor that is used as a prodrug to the neurotransmitter norepinephrine. It is primarily used for the treatment of neurogenic orthostatic hypotension, a condition characterized by a sudden drop in blood pressure upon standing. Droxidopa works by increasing the levels of norepinephrine in the body, which helps to regulate blood pressure and improve symptoms of orthostatic hypotension. It is typically administered orally in the form of capsules and has been shown to be effective in improving standing blood pressure and reducing symptoms such as dizziness, lightheadedness, and fainting in patients with neurogenic orthostatic hypotension. Droxidopa has also been investigated for its potential therapeutic benefits in conditions such as fibromyalgia and fatigue in patients with Parkinson's disease.
Check Digit Verification of cas no
The CAS Registry Mumber 169032-03-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,9,0,3 and 2 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 169032-03:
(8*1)+(7*6)+(6*9)+(5*0)+(4*3)+(3*2)+(2*0)+(1*3)=125
125 % 10 = 5
So 169032-03-5 is a valid CAS Registry Number.
169032-03-5Relevant articles and documents
Synthetic studies on aphidicolane and stemodane diterpenes. III. An alternative stereoselective access to aphidicolane-type B/C/D-ring system
Tanaka,Murakami,Okuda,Kuroda,Inoue,Kamei,Murata,Yoshino,Imanishi,Iwata
, p. 1756 - 1759 (1994)
Compound 2, corresponding to the B/C/D-ring for aphidicolane-type diterpenes, was synthesized stereoselectively from a perhydroindane derivative (3) which was obtained by rhodium-alumina catalyzed hydrogenation of an indane ester (4) as a key step.
