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4-Hydroxy-2,3-dihydro-1H-indene-2-carboxylic acid, also known as droxidopa, is a synthetic amino acid precursor that serves as a prodrug to the neurotransmitter norepinephrine. It is a compound with significant therapeutic potential, primarily utilized for the treatment of neurogenic orthostatic hypotension, a condition where blood pressure drops abruptly upon standing.
Used in Pharmaceutical Industry:
4-Hydroxy-2,3-dihydro-1H-indene-2-carboxylic acid is used as a therapeutic agent for the treatment of neurogenic orthostatic hypotension. It functions by increasing the levels of norepinephrine in the body, which aids in regulating blood pressure and mitigating symptoms such as dizziness, lightheadedness, and fainting in affected patients.
Used in Neurological Conditions:
4-Hydroxy-2,3-dihydro-1H-indene-2-carboxylic acid is used as a potential therapeutic agent for conditions like fibromyalgia and fatigue in patients with Parkinson's disease. Its investigation in these areas highlights its potential to address a broader range of neurological symptoms and disorders beyond its primary application in orthostatic hypotension.
Used in Drug Formulation:
4-Hydroxy-2,3-dihydro-1H-indene-2-carboxylic acid is used as an active pharmaceutical ingredient, typically administered orally in the form of capsules. This method of administration has been demonstrated to effectively improve standing blood pressure and reduce the symptoms associated with neurogenic orthostatic hypotension.

169032-03-5

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169032-03-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 169032-03-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,9,0,3 and 2 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 169032-03:
(8*1)+(7*6)+(6*9)+(5*0)+(4*3)+(3*2)+(2*0)+(1*3)=125
125 % 10 = 5
So 169032-03-5 is a valid CAS Registry Number.

169032-03-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-Hydroxy-2,3-dihydro-1H-indene-2-carboxylic acid

1.2 Other means of identification

Product number -
Other names 4-hydroxy-2,3-dihydro-1H-indene-2-carboxylic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:169032-03-5 SDS

169032-03-5Downstream Products

169032-03-5Relevant academic research and scientific papers

Synthetic studies on aphidicolane and stemodane diterpenes. III. An alternative stereoselective access to aphidicolane-type B/C/D-ring system

Tanaka,Murakami,Okuda,Kuroda,Inoue,Kamei,Murata,Yoshino,Imanishi,Iwata

, p. 1756 - 1759 (1994)

Compound 2, corresponding to the B/C/D-ring for aphidicolane-type diterpenes, was synthesized stereoselectively from a perhydroindane derivative (3) which was obtained by rhodium-alumina catalyzed hydrogenation of an indane ester (4) as a key step.

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