169280-04-0

Basic information

• Product Name: 1-Butanone, 1-[4-(1-bromo-1-methylethyl)phenyl]-4-chloro-
• CAS NO: 169280-04-0
• Molecular Formula: C13H16BrClO
• Molecular Weight: 303.626
• Mol File: 169280-04-0.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 1-Butanone, 1-[4-(1-bromo-1-methylethyl)phenyl]-4-chloro-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Butanone, 1-[4-(1-bromo-1-methylethyl)phenyl]-4-chloro-(169280-04-0)
• EPA Substance Registry System: 1-Butanone, 1-[4-(1-bromo-1-methylethyl)phenyl]-4-chloro-(169280-04-0)

Safety Data

• Hazardous Substances Data: 169280-04-0(Hazardous Substances Data)

Upstream product

• 98-82-8 Isopropylbenzene 
• 77-48-5 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione 
• 70289-38-2 4-Chloro-1-(4-isopropyl-phenyl)-butan-1-one 
• 75-09-2 dichloromethane 

Downstream Products

• 169032-17-1 2-[4-(4-chloro-butyryl)-phenyl]-2-methyl-propionitrile 
• 873072-14-1 1-[4-(1-hydroxy-1-methyl-ethyl)-phenyl]-4-chloro-butan-1-one 
• 169280-21-1 2-[4-(4-chloro-butyryl)-phenyl]-2-methyl-propionic acid 
• 83799-24-0 fexofenadine 
• 76811-98-8 4-[4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-oxobutyl]-α,α-dimethylbenzeneacetic acid 

Relevant articles and documents

A fexofenadine and method for synthesizing intermediate

The invention relates to a simple and efficient synthetic method of fexofenadine (chemical name: 4-{1-hydroxyl-4-[4-(hydroxyl benzhydryl)-1-piperidyl]-butyl}-alpha, alpha-dimethyl-phenylacetic acid (I)) and its intermediate. According to the method, isopropyl benzene is used as a raw material. Through a Friedel-Crafts acylation reaction, a halogenation reaction and a carbonyl insertion reaction, a key intermediate 4-(4-chloro-1-butyryl)-alpha, alpha-dimethyl phenylacetic acid (IV) is obtained; the key intermediate reacts with another raw material dibenzyl-(4-pyridyl)-methanol (E) to obtain a key pyridinium intermediate 4-{4-chloro-[4-hydroxydiphenylmethyl]-1-pyridinium]-1-butyryl}-alpha, alpha-dimethyl phenylacetic acid (V); and through catalytic hydrogenation and metallic hydrogen reduction, high-purity fexofenadine is obtained. The synthetic method provided by the invention has advantages of smooth process, simple reaction, short route, convenient post-treatment, high yield and low cost, and is a very ideal preparation method of fexofenadine and industrialization feasible route.

METHOD FOR CARBONYLATING PHENYLALKYL DERIVATIVES BY MEANS OF CARBON MONOXIDE

The invention relates to a method for producing a phenylalkyl carboxylic acid of general formula (I), wherein identical or different R1 and R2 represent independently of each other -(C1-C4)-alkyl, Z is a hydrogen atom or -(CH2) n-CH3, wherein n=0 to 9, and R3 is-C(0)-(C1-C4)-alkyl which is substituted or not-substituted by CI or Br, only, or -C(0)-(C3-C6)-cycloalkyl, consisting in reacting a compound of formula (II), wherein X is Cl or Br or OH and R4 is defined as R2 rest represents jointly with X a C-C double bond with a carbon monoxide in the presence of a concentrated sulphuric acid, hydrogen fluoride or peracids and subsequently in adding water or alcohol of the formula CH3-(CH2)n-OH, wherein n=0 to 9.

Intermediates useful for the preparation of antihistaminic piperidine derivatives

The present invention is related to a novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of the formula whereinW represents —C(=O)— or —CH(OH)—;R1 represents hydrogen or hydroxy;R2 represents hydrogen;R1 and R2 taken together form a second bond between the carbon atoms bearing R1 and R2;n is an integer of from 1 to 5;m is an integer 0 or 1;R3 is —COOH or —COOalkyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched each of A is hydrogen or hydroxy; and pharmaceutically acceptable salts and individual optical isomers thereof,with the proviso that where R1 and R2 are taken together to form a second bond between the carbon atoms bearing R1 and R2 or where R1 represented hydroxy, m is an integer 0.