1693-05-6

Basic information

• Product Name: Benzenebutanoic acid, 4-fluoro-, ethyl ester
• Synonyms: Benzenebutanoic acid, 4-fluoro-, ethyl ester
• CAS NO: 1693-05-6
• Molecular Formula: C₁₂H₁₅FO₂
• Molecular Weight: 210.2447032
• Mol File: 1693-05-6.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 281.84°C at 760 mmHg
• Flash Point: 120.429°C
• Appearance: /
• Density: 1.073g/cm³
• Vapor Pressure: 0.003mmHg at 25°C
• Refractive Index: 1.484
• CAS DataBase Reference: Benzenebutanoic acid, 4-fluoro-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenebutanoic acid, 4-fluoro-, ethyl ester(1693-05-6)
• EPA Substance Registry System: Benzenebutanoic acid, 4-fluoro-, ethyl ester(1693-05-6)

Safety Data

• Hazardous Substances Data: 1693-05-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H15FO2/c1-2-15-12(14)5-3-4-10-6-8-11(13)9-7-10/h6-9H,2-5H2,1H3

Upstream product

• 462-06-6 fluorobenzene 
• 2969-81-5 Ethyl 4-bromobutyrate 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 405-99-2 para-fluorostyrene 
• 140-88-5 ethyl acrylate 
• 459-46-1 4-Fluorobenzyl bromide 
• 459-57-4 4-fluorobenzaldehyde 
• 623-51-8 ethyl 2-sulfanylacetate 
• 19493-09-5 Methylenetriphenylphosphorane 
• 352-11-4 1-chloromethyl-4-fluorobenzene 
• 366-77-8 4-(4-fluorophenyl)-4-oxopropionic acid 
• 64-17-5 ethanol 
• 589-06-0 4-(4-fluorophenyl)butanoic acid 
• 623-73-4 diazoacetic acid ethyl ester 

Downstream Products

• 40283-05-4 4-(4-fluorophenyl)-1-butanol 
• 711-80-8 7-Fluor-3,4-dihydro-naphthoesaeure-⁽¹⁾ 
• 89326-72-7 6-(4'-fluorophenyl)hexanoic acid 
• 89326-70-5 1-bromo-4-(4-fluorophenyl)-butane 
• 89326-76-1 6-(4-Fluoro-phenyl)-hexanoyl chloride 
• 89326-71-6 ethyl 2-ethoxycarbonyl-6-(4'-fluorophenyl)hexanoate 
• 89347-14-8 6-(4-Fluoro-phenyl)-hexanoic acid (8R,9S,10R,13S,14S,17R)-17-ethynyl-13-methyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl ester 
• 30087-09-3 Phosphoric acid 2,2-dichloro-vinyl ester 4-(4-fluoro-phenyl)-butyl ester methyl ester 
• 1431791-92-2 6-(4-fluorophenyl)-3-oxohexanenitrile 
• 1431791-16-0 2-diazo-6-(4-fluorophenyl)-3-oxohexanenitrile 

Relevant articles and documents

Coupling Photocatalysis and Substitution Chemistry to Expand and Normalize Redox-Active Halides

Photocatalysis can generate radicals in a controlled fashion and has become an important synthetic strategy. However, limitations due to the reducibility of alkyl halides prevent their broader implementation. Herein we explore the use of nucleophiles that can substitute the halide and serve as an electron capture motif that normalize the variable redox potentials across substrates. When used with photocatalysis, bench-stable, commercially available collidinium salts prove to be excellent radical precursors with a broad scope.

Mechanical metal activation for Ni-catalyzed, Mn-mediated cross-electrophile coupling between aryl and alkyl bromides

Liquid-assisted grinding has been successfully applied to eliminate the requirements of chemical activators and anhydrous solvents in nickel-catalyzed, manganese-mediated cross-electrophile coupling between aryl and alkyl bromides. In addition to the traditional reaction parameters, mechanical ones,e.g.the rotational speed of mill, the filling degree of jar and ball size, have been found to affect the catalytic efficiency remarkably, implying the involvement of the regeneration of nickel(0) species in the rate-determining steps. A combined evaluation of the reaction and mechanical parameters led to an optimal condition under which a variety ofn-alky aromatics with various functional groups could be readily obtained in good yields with a 1 mol% catalyst loading. The practical application of liquid-assisted grinding-enabled aryl/alkyl cross-electrophile coupling has been demonstrated in the gram-scale synthesis of 6-methoxytetralone.

Preparation method of substituted butyrate derivatives

The invention discloses a preparation method of substituted butyrate derivatives. The method specifically comprises the following steps: by taking compounds shown in a formula 1, a formula 2 and a formula 3 as raw materials, carrying out an illumination reaction process in the presence of a photocatalyst and a hydrogen transfer catalyst to obtain a target compound shown in a formula I through one-step reaction. The invention discloses a free radical-mediated olefin bifunctional reaction without a cyclopropanation intermediate. The reaction can realize a product which can be obtained through cyclopropanation and cyclopropane ring opening processes traditionally in one step. Meanwhile, the preparation method of the compound is simple, uses cheap and easily available compounds as raw materials, and has the beneficial effects of one-step synthesis, mild reaction conditions, fast reaction, low cost, less generated waste, simple and safe operation, high atom economy, high selectivity, extremely wide substrate applicability, high yield and the like.