169334-87-6Relevant academic research and scientific papers
Synthesis and biological activity of heterocyclic aminophosphonates
Boduszek, Bogdan
, p. 433 - 436 (1999)
A variety of synthetic methods for preparation of heterocyclic aminophosphonates is presented; which are concerning furyl, thienyl, pyrryl and pyridyl derivatives of aminomethanephosphonic acid and also phosphonic analogues of proline and homoproline. The obtained heterocyclic aminophosphonates were used as starting materials for synthesis of some peptidyl phosphonates. The compounds were evaluated as inhibitors of serine proteases. Most of the obtained heterocyclic aminophosphonates were preliminary tested as potential herbicides against selected plants, and some of them showed the herbicidal activity.
AN EFFICIENT SYNTHESIS OF 1-AMINOPHOSPHONIC ACIDS AND ESTERS BEARING HETEROCYCLIC MOIETY
Boduszek, Bogdan
, p. 63 - 70 (2007/10/03)
New α-aminophosphonic esters and acids derived from furan, thiophene and pyrazole were prepared in high yield, in the reactions of benzylamine, benzhydrylamine or benzyl carbamate with heterocyclic aldehydes and diethyl or diphenyl phosphonates.The protecting groups at amine (benzyl or benzhydryl) were removed by hydrogenolysis or hydrolysis, respectively.The N-benzoyloxycarbonyl (Z-group) was removed by treatment with 45percent HBr in acetic acid. Key words: Diphenyl α-aminofurylmethyl phosphonate, α-aminothienylmethylphosphonic acid, α-aminopyrazolylmethylphosphonic acid, imines, benzyl carbamate.
