16936-96-2Relevant academic research and scientific papers
Direct C-H amidation of benzoic acids to introduce meta- and para-amino groups by tandem decarboxylation
Lee, Donggun,Chang, Sukbok
, p. 5364 - 5368 (2015/03/30)
The Ir-catalyzed mild C-H amidation of benzoic acids with sulfonyl azides was developed to give reactions with high efficiency and functional-group compatibility. Subsequent protodecarboxylation of ortho-amidated benzoic acid products afforded meta- or para-substituted (N-sulfonyl)aniline derivatives, the latter being inaccessible by other C-H functionalization approaches. The decarboxylation step was compatible with the amidation conditions, enabling a convenient one-pot, two-step process. Without a trace: Carboxylic acids are used as traceless directing groups in the Ir-catalyzed direct C-H amidation of arenes with sulfonyl azides under mild conditions. The tandem protodecarboxylation of the ortho-amidated benzoic acid products afforded meta- or para-substituted (N-sulfonyl)anilines, which are difficult to obtain by other C-H functionalization approaches.
Synthesis of biotinylated photoaffinity probes based on arylsulfonamide γ-secretase inhibitors
Fuwa, Haruhiko,Hiromoto, Kenichi,Takahashi, Yasuko,Yokoshima, Satoshi,Kan, Toshiyuki,Fukuyama, Tohru,Iwatsubo, Takeshi,Tomita, Taisuke,Natsugari, Hideaki
, p. 4184 - 4189 (2007/10/03)
Synthesis and biological evaluation of an arylsulfonamide class of γ-secretase inhibitors are described. Design, synthesis, and biological evaluation of multifunctional molecular probes harboring a benzophenone photophore as a cross-linking group and a biotin tag are also reported.
