169613-97-2Relevant academic research and scientific papers
Chemoenzymatic route to S-betaxolol
Li, Yong-Hong,Huang, Li-Hua,Liu, Hong-Min
, p. 2468 - 2474 (2011)
An efficient chemoenzymatic route to S-betaxolol is reported. A strain (Rhodotorula mucilaginosa DQ832198) screened from soil was used as biocatalyst for the kinetic resolution of the key acetylated intermediates. Excellent enantiomeric excess (ee99%) was
A chemoenzymatic route to both enantiomers of betaxolol
Di Bono,Scilimati
, p. 699 - 702 (2007/10/02)
Evaluation of some of the possible lipase-catalyzed transformations has been done in order to prepare both enantiomers of betaxolol. Resolution of betaxolol by lipase-catalyzed hydrolysis of its bisacetylated derivatives 4 led to (-)- and (+)-enantiomers with an ee of 20 and 60%, respectively. When the resolution was performed on the chlorohydrin precursor 6 of betaxolol, (-)- and (+)-enantiomers were obtained with an ee of 91 and 75%, respectively.
