93221-48-8

Basic information

• Product Name: LEVOBETAXOLOL
• Synonyms: (2S)-1-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-3-(isopropylamino)propan-2-ol;(2S)-1-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-3-(propan-2-ylamino)propan-2-ol;(S)-1-[4-[2-(Cyclopropylmethoxy)ethyl]phenoxy]-3-[(1-methylethyl)amino]-2-propanol;Levoβxolol HCl;LEVOBETAXOLOL;(S)-(-)-Betaxolol;(S)-Betaxolol;2-Propanol, 1-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-3-[(1-methylethyl)amino]-, (2S)-
• CAS NO: 93221-48-8
• Molecular Formula: C₁₈H₂₉NO₃
• Molecular Weight: 307.43
• Mol File: 93221-48-8.mol
• Article Data: 10

Chemical Properties

• Melting Point: 71-72℃
• Boiling Point: 448°C at 760 mmHg
• Flash Point: 224.7°C
• Appearance: /
• Density: 1.067
• Vapor Pressure: 8.26E-09mmHg at 25°C
• Refractive Index: 1.529
• PKA: 13.89±0.20(Predicted)
• CAS DataBase Reference: LEVOBETAXOLOL(CAS DataBase Reference)
• NIST Chemistry Reference: LEVOBETAXOLOL(93221-48-8)
• EPA Substance Registry System: LEVOBETAXOLOL(93221-48-8)

Safety Data

• Hazardous Substances Data: 93221-48-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C18H29NO3/c1-14(2)19-11-17(20)13-22-18-7-5-15(6-8-18)9-10-21-12-16-3-4-16/h5-8,14,16-17,19-20H,3-4,9-13H2,1-2H3/t17-/m0/s1

Upstream product

• 874112-86-4 S-(-)-1-{4-[2-(allyloxy)-ethyl]phenoxy}-3-isopropylamino propan-2-ol 
• 75-11-6 diiodomethane 
• 947340-61-6 (5S)-2-(4-((3-isopropyl-2-phenyloxazolidin)-5-methoxy)phenyl)-4-ethanol 
• 63659-18-7 betaxolol 
• 62572-94-5 (+/-)-O-Demethylmetoprolol 
• 169613-97-2 Acetic acid (S)-2-(acetyl-isopropyl-amino)-1-[4-(2-cyclopropylmethoxy-ethyl)-phenoxymethyl]-ethyl ester 
• 169613-96-1 1-(N-acetyl-N-isopropyl)amino-3-<4-(2-cyclopropylmethoxy)ethyl>phenoxyprop-2-yl acetate 
• 7051-34-5 cyclopropylcarbinyl bromide 
• 131564-69-7 (-)-O-Demethylmetoprolol 
• 1312687-84-5 C₁₈H₂₇NO₅ 
• 959279-50-6 C₂₀H₂₉NO₆ 
• 75-31-0 isopropylamine 
• 86587-72-6 (S)-(-)-2-phenyl-3-isopropyl-5-<(tosyloxy)methyl>oxazolidine 
• 56441-69-1 2-<4-(phenylmethoxy)phenyl>acetic acid ethyl ester 

Downstream Products

• 93221-49-9 (S)-(-)-3-<4-<2-(cyclopropylmethoxy)ethyl>phenoxy>-1-(isopropylamino)-2-propanol maleate 

Relevant articles and documents

Technique for synthesizing levorotatory betaxolol hydrochloride (by machine translation)

The invention discloses a technique for synthesizing levorotatory betaxolol hydrochloride, the process adopts to hydroxy phenylacetic alcohol and R- epoxy halogen propane is used as starting material, under certain conditions after alkylation, amination,

Chemoenzymatic route to S-betaxolol

An efficient chemoenzymatic route to S-betaxolol is reported. A strain (Rhodotorula mucilaginosa DQ832198) screened from soil was used as biocatalyst for the kinetic resolution of the key acetylated intermediates. Excellent enantiomeric excess (ee99%) was

PROCESS FOR PREPARATION OF S-(-)-BETAXOLOL AND SALTS THEREOF

The present invention relates to an improved process for preparation of S-(?)-betaxolol salts. More particularly the present invention relates to the preparation of hydrochloride salt of S-(?)-betaxolol of formula (1).