169736-18-9

Upstream product

• 100-39-0 benzyl bromide 
• 13039-67-3 (2S,3S,4S)-2-(hydroxymethyl)-5-methoxyoxolane-3,4-diol 

Downstream Products

• 135910-13-3 (3R,4R,5R)-3,4,6-tris(benzyloxy)hexane-1,5-diol 
• 909801-49-6 (2R,3R,4R)-N-benzyloxycarbonyl-1,3,4-tris(benzyloxy)-2-(but-3-enylamino)-hex-5-ene 
• 909801-45-2 (2R,3R,4R)-1,3,4-Tris(benzyloxy)-N-(but-3-en-1-yl)hex-5-en-2-amine 
• 724705-48-0 (2R,3R,4R)-benzyl 3,4-bis(benzyloxy)-2-[(benzyloxy)methyl]-2,3,4,7-tetrahydro-1H-azepine-1-carboxylate 
• 724705-47-9 (3R,4R,5R)-N-benzyloxycarbonyl-5-allylamino-3,4,6-tribenzyloxy-hex-1-ene 
• 160925-98-4 benzyl [(2R,3R,4R)-1,3,4-tris(benzyloxy)hex-5-en-2-yl]carbamate 
• 161290-44-4 (1R,2R,3R)-2,3-Bis-benzyloxy-1-benzyloxymethyl-pent-4-enylamine 
• 203112-67-8 2-[(2R,3R,4R)-1,3,4-tris(benzyloxy)hex-5-en-2-yl]isoindoline-1,3-dione 
• 1129725-82-1 (2S,3R,4R)-1-benzyl-3,4-bis(benzyloxy)-2-[(benzyloxy)methyl]piperidine 
• 135910-18-8 (2R,3S,4S)-2,3,5-tri(benzyloxy)-1,4-di(methylsulfonyloxy)pentane 
• 137820-47-4 (3R,4R,5S)-5-hydroxy-3,4,6-tribenzyloxy-1-hexene 
• 162491-58-9 (5R,6R,7R,8S)-8-azido-6,7-bis(benzyloxy)-5-[(benzyloxy)methyl]-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine 
• 181782-18-3 Acetic acid (5R,6R,7S,8S)-6,7-bis-benzyloxy-5-benzyloxymethyl-5,6,7,8-tetrahydro-imidazo[1,2-a]pyridin-8-yl ester 

Relevant academic research and scientific papers

Synthesis of d -Fagomine and Its Seven- and Eight-Membered Higher-Ring Analogues, and the Formal Synthesis of (+)-Australine from l -Xylose-Derived Chiron

The synthesis of d-fagomine and its seven- and eight-membered higher-ring analogues from commercially available l-xylose is reported. The syntheses involve elaboration of a common alkenol precursor obtained from l-xylose-derived hemiacetal. The key steps

PYRROLIDINE DERIVATIVES AS SELECTIVE GLYCOSIDASE INHIBITORS AND USES THEREOF

Disclosed are compounds of formula (I): or a pharmaceutically acceptable salt, derivative, solvate, isomer, tautomer, N-oxide, ester, prodrug, isotope or protected form thereof, which are of use as OGA inhibitors, for example in the treatment of various conditions and diseases, including neurodegenerative disorders.

PYRROLIDINE DERIVATIVES AS SELECTIVE GLYCOSIDASE INHIBITORS AND USES THEREOF

Disclosed are compounds of formula (I) or a pharmaceutically acceptable salt, derivative, solvate, isomer, tautomer, N-oxide, ester, prodrug, isotope or protected form thereof, which are of use as OGA inhibitors, for example in the treatment of various conditions and diseases, including neurodegenerative disorders

Preparation of thioarabinofuranosyl compounds and use thereof

Patients suffering from cancer are treated by being administered a compound represented by the following formula: wherein each R individually is H or an aliphatic or aromatic acyl group; A is selected from the group consisting of wherein X is selected from the group consisting of hydrogen, fluorine, alkoxy, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, amino, monoalkylamino, dialkylamino, cyano and nitro. The above compounds also inhibit DNA replication in mammalian cells,

Synthesis of 6-deoxy-homoDMDP and its C(5)-epimer: Absolute stereochemistry of natural products from Hyacinthus orientalis

A concise enantioselective synthesis of 2,5-imino-2,5,6-trideoxy-D-manno-heptitol (6-deoxy-homoDMDP) and 2,5-imino-2,5,6-trideoxy-L-gulo-heptitol has been achieved. These compounds were used as stereochemical references to establish the absolute configuration of the corresponding naturally occurring stereoisomers, recently isolated from Hyacinthus orientalis.

A facile and rapid route to a new series of pyrrolizidines structurally related to (+)-alexine and (+)-australine

Addition of allylmagnesium chloride to protected L-xylofuranosylamine gave, after intramolecular cyclization, the corresponding polyhydroxylated 2-allylpyrrolidines. New series of analogues of (+)-alexine and (+)-australine were readily obtained from these intermediates by dihydroxylation, intramolecular nucleophilic displacement and subsequent deprotection. The determination of the configuration at the newly formed stereocentres was based on NMR experiments. Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002.

The synthesis and biological activity of certain 4'-thionucleosides

Results are presented on the synthesis and biological activity of several types of 4'-thionucleosides as potential anticancer agents. Detailed studies on the mechanism of action of 4'-thiothymidine are also presented.

Total Syntheses of De-branched Nagstatin and Its Analogs Having Glycosidase Inhibiting Activities

De-branched nagstatin and its analogs have been synthesized from protected L-ribo- and xylo-furanoses through the inter- and intra-molecular nucleophilic reactions with the imidazole moieties.

α-glucosidase inhibitors

This invention relates to novel N-glycosyl derivatives of 1,4-dideoxy-1,4-imino-D-arabinitol, to the chemical processes for their preparation, to their α-glucosidase inhibiting properties, and to their end-use application in the treatment of diabetes, obe