169765-81-5

Upstream product

• 5036-48-6 3-(1H-imidazol-1-yl)propan-1-amine 
• 4291-63-8 2-chloro-2'-deoxyadenosine 
• 136834-45-2 (2R,3S,5R)-5-[6-Amino-2-(3-imidazol-1-yl-propylamino)-purin-9-yl]-2-hydroxymethyl-tetrahydro-furan-3-ol 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 155369-05-4 N-[9-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2-(3-imidazol-1-yl-propylamino)-9H-purin-6-yl]-isobutyramide 

Relevant academic research and scientific papers

Remarkable Enhancement of Binding Affinity of Heterocycle-Modified DNA to DNA and RNA. Synthesis, Characterization and Biophysical Evaluation of N2-Imidazolylpropylguanine and N2-Imidazolylpropyl-2-aminoadenine Modified Oligonucleotides.

Oligonucleotides containing novel N2-Imidazolylpropylguanine and N2-Imidazolylpropyl-2-aminoadenine moieties were synthesized and studied for their hybridization and biophysical properties.Interestingly, these heterocycle modified oligonucleotides showed a remarkable enhancement of heteroduplex binding when hybridized to complementary DNA.