Tetrahedron Letters p. 215 - 218 (1994)
Update date:2022-08-03
Topics:
Ramasamy, Kanda S.
Zounes, Maryann
Gonzalez, Carolyn
Freier, Susan M.
Lesnik, Elena A.
et al.
Oligonucleotides containing novel N2-Imidazolylpropylguanine and N2-Imidazolylpropyl-2-aminoadenine moieties were synthesized and studied for their hybridization and biophysical properties.Interestingly, these heterocycle modified oligonucleotides showed a remarkable enhancement of heteroduplex binding when hybridized to complementary DNA.
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