Remarkable Enhancement of Binding Affinity of Heterocycle-Modified DNA to DNA and RNA. Synthesis, Characterization and Biophysical Evaluation of N2-Imidazolylpropylguanine and N2-Imidazolylpropyl-2-aminoadenine Modified Oligonucleotides.

DOI: 10.1016/S0040-4039(00)76514-2

Source and publish data:

Tetrahedron Letters p. 215 - 218 (1994)

Update date:2022-08-03

Topics:

Authors:

Ramasamy, Kanda S.

Zounes, Maryann

Gonzalez, Carolyn

Freier, Susan M.

Lesnik, Elena A.

et al. et al.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4039(00)76514-2

Oligonucleotides containing novel N²-Imidazolylpropylguanine and N²-Imidazolylpropyl-2-aminoadenine moieties were synthesized and studied for their hybridization and biophysical properties.Interestingly, these heterocycle modified oligonucleotides showed a remarkable enhancement of heteroduplex binding when hybridized to complementary DNA.

Full text of DOI:10.1016/S0040-4039(00)76514-2

Products guided by the article

Product name:N-[9-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2-(3-imidazol-1-yl-propylamino)-9H-purin-6-yl]-isobutyramide

Cas No:169765-81-5

R&D Labs maybe for 169765-81-5

Henan zhongda Biological Engineering Co., Ltd

Contact:86-28-18109029985

Address:shenzhou road,xuedian industrial estate,zhengzhou city,henan province CHN
Kono Chem Co.,Ltd

website:http://www.konochem.com

Contact:86-29-86107037

Address:No.170 West Avenue,Xi’an 710082,China
ORCHID CHEMICAL SUPPLIES LTD

website:http://www.orchid-chem.com

Contact:+86-571-85395792

Address:607, North Zhongshan Road, Hangzhou 310000 China
Guangxi Nanning Guangtai Agriculture Chemical Co.,Ltd

Contact:+86-771-2311266

Address:Room703,Building12, Software Park Phase II,NO.68,Keyuan Road,Nanning City,Guangxi,China
Anhui Gusheng Import&Export CO.,LTD

Contact:86-551-63662296

Address:Jinzhai Road NO.162 ,hefei, china

Relevant to this article

Doi:10.1021/ja00713a031
(1970)
Stereoselective diels-alder reactions of chiral anthracenes

Doi:10.1021/ol006206m
(2000)
Reaction between hydrazines and chiral α-acetylenic ketones: Synthesis of novel enantiomerically pure pyrazolyl-β-amino alcohols

Doi:10.1016/S0957-4166(00)00204-4
(2000)
Ring-closing metathesis of titanium - Carbene complexes prepared from thioacetals having a carbon - Carbon double bond

Doi:10.1016/S0040-4020(00)00201-5
(2000)
Doi:10.1016/0040-4020(58)80023-X
(1958)
Ureas from Lossen Rearrangements of Hydroxamic Acids Induced by p-Toluenesulfonyl Chloride or 2-Chloro-1-methylpyridinium Iodide in the Presence of Amines: A Correction

Doi:10.1055/s-1989-27154
(1989)

Article Doi