Remarkable Enhancement of Binding Affinity of Heterocycle-Modified DNA to DNA and RNA. Synthesis, Characterization and Biophysical Evaluation of N2-Imidazolylpropylguanine and N2-Imidazolylpropyl-2-aminoadenine Modified Oligonucleotides.

DOI: 10.1016/S0040-4039(00)76514-2

Source and publish data:

Tetrahedron Letters p. 215 - 218 (1994)

Update date:2022-08-03

Topics:

Authors:

Ramasamy, Kanda S.

Zounes, Maryann

Gonzalez, Carolyn

Freier, Susan M.

Lesnik, Elena A.

et al. et al.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4039(00)76514-2

Oligonucleotides containing novel N²-Imidazolylpropylguanine and N²-Imidazolylpropyl-2-aminoadenine moieties were synthesized and studied for their hybridization and biophysical properties.Interestingly, these heterocycle modified oligonucleotides showed a remarkable enhancement of heteroduplex binding when hybridized to complementary DNA.

Full text of DOI:10.1016/S0040-4039(00)76514-2

Products guided by the article

Product name:N-[9-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2-(3-imidazol-1-yl-propylamino)-9H-purin-6-yl]-isobutyramide

Cas No:169765-81-5

R&D Labs maybe for 169765-81-5

Anyang Double Circle Auxiliary CO.,LTD

Contact:0086-134 6082 4403

Address:dongfeng road, anyang city, henan province,china
Shanghai Hope Chem Co., Ltd

website:http://www.hope-chem.com

Contact:86-21-58090396-805

Address:Floor 4, Building 5, No.588 Tianxiong Road, Zhoupu International Medical Zone, ShangHai, China
Guangzhou Probig Fine Chemical Co., Ltd.

Contact:020-86297874

Address:No.2, 1/F, No.20, Hetai Road,Hebian Village, Baiyun District,Guangzhou,China
QINGDAO TAOSIGN INTERNATIONAL TRADE CO.,LIMITED

Contact:+86-0532-82683616

Address:RM1402, Doublestar Seacoase 7#, No. 5 Guizhou Road, Qingdao, Shandong, China
Shanghai Hanhong Scientific Co.,Ltd.

website:http://www.chemvia.com

Contact:+86-21-64541543,54280654,13918533501

Address:Jiachuan Road 245

Relevant to this article

Doi:10.1021/ja00713a031
(1970)
Stereoselective diels-alder reactions of chiral anthracenes

Doi:10.1021/ol006206m
(2000)
Reaction between hydrazines and chiral α-acetylenic ketones: Synthesis of novel enantiomerically pure pyrazolyl-β-amino alcohols

Doi:10.1016/S0957-4166(00)00204-4
(2000)
Ring-closing metathesis of titanium - Carbene complexes prepared from thioacetals having a carbon - Carbon double bond

Doi:10.1016/S0040-4020(00)00201-5
(2000)
Doi:10.1016/0040-4020(58)80023-X
(1958)
Ureas from Lossen Rearrangements of Hydroxamic Acids Induced by p-Toluenesulfonyl Chloride or 2-Chloro-1-methylpyridinium Iodide in the Presence of Amines: A Correction

Doi:10.1055/s-1989-27154
(1989)

Article Doi