1698-80-2

Basic information

• Product Name: 10H-Phenothiazine-10-propanenitrile
• Synonyms: 10H-Phenothiazine-10-propanenitrile;Phenothiazine-10-propionitrile;10-(2-Cyanoethyl)phenothiazine;3-(Phenothiazin-10-yl)propanenitrile;NSC 139052;NSC 21556
• CAS NO: 1698-80-2
• Molecular Formula: C₁₅H₁₂N₂S
• Molecular Weight: 252.3342
• Product Categories: Aromatics;Heterocycles;Intermediates;Sulfur & Selenium Compounds
• Mol File: 1698-80-2.mol

Chemical Properties

• Melting Point: 158-159 °C
• Boiling Point: 448.8°Cat760mmHg
• Flash Point: 225.2°C
• Appearance: /
• Density: 1.236g/cm³
• Vapor Pressure: 3.02E-08mmHg at 25°C
• Refractive Index: 1.653
• Storage Temp.: -20°C Freezer
• Solubility: Chloroform (Slightly, Methanol (Slightly)
• PKA: -0.33±0.20(Predicted)
• CAS DataBase Reference: 10H-Phenothiazine-10-propanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 10H-Phenothiazine-10-propanenitrile(1698-80-2)
• EPA Substance Registry System: 10H-Phenothiazine-10-propanenitrile(1698-80-2)

Safety Data

• Hazardous Substances Data: 1698-80-2(Hazardous Substances Data)

Usage

Uses

Used in Chemical Synthesis:
10H-Phenothiazine-10-propanenitrile is used as a reagent for the addition of Phenothiazine (P318040). This application is significant in the chemical industry, as it allows for the synthesis of various phenothiazine derivatives with different properties and potential uses.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 10H-Phenothiazine-10-propanenitrile is used as an intermediate in the synthesis of various drugs, particularly those with antipsychotic, antiemetic, and antihistamine properties. The compound's unique structure contributes to the development of new medications with improved efficacy and reduced side effects.
Used in Dye Industry:
10H-Phenothiazine-10-propanenitrile is also utilized in the dye industry as a starting material for the production of various dyes and pigments. Its chemical properties make it suitable for creating a wide range of colors, which can be used in various applications such as textiles, plastics, and printing inks.
Used in Analytical Chemistry:
In analytical chemistry, 10H-Phenothiazine-10-propanenitrile is employed as a reagent for the detection and quantification of specific substances. Its unique chemical properties enable it to selectively react with target analytes, making it a valuable tool for research and quality control in various industries.

InChI:InChI=1/C15H12N2S/c16-10-5-11-17-12-6-1-3-8-14(12)18-15-9-4-2-7-13(15)17/h1-4,6-9H,5,11H2

Upstream product

• 92-84-2 10H-phenothiazine 
• 107-13-1 acrylonitrile 
• 2417-90-5 bromopropionitrile 

Downstream Products

• 5909-59-1 10-(3-chloropropyl)-10H-phenothiazine 
• 109510-69-2 3-phenothiazin-10-yl-propionamidine; hydrochloride 
• 1612155-90-4 prop-2-ynyl N-[3-(10H-phenothiazin-10-yl)propanoyl]glycylglycyltyrosinate 
• 1612155-89-1 N-[3-(10H-phenothiazin-10-yl)propanoyl]glycylglycyl-N'-prop-2-ynyltyrosinamide 
• 1612155-88-0 prop-2-ynyl N-[3-(10H-phenothiazin-10-yl)propanoyl]glycyltyrosinate 
• 1612155-87-9 N-[3-(10H-phenothiazin-10-yl)propanoyl]glycyl-N'-prop-2-ynyltyrosinamide 
• 1612155-81-3 prop-2-ynyl N-[3-(10H-phenothiazin-10-yl)propanoyl]tyrosinate 
• 1612155-79-9 N-[3-(10H-phenothiazin-10-yl)propanoyl]-N'-prop-2-ynyltyrosinamide 
• 1612155-75-5 N-[3-(10H-phenothiazin-10-yl)propanoyl]tyrosine 
• 1612155-77-7 methyl N-[3-(10H-phenothiazin-10-yl)propanoyl]tyrosinate 
• 1390635-79-6 N-({1-[2-(4-methoxyphenyl)-2-oxoethyl]-1H-1,2,3-triazol-4-yl}methyl)-3-(10H-phenothiazin-10-yl)propanamide 
• 1390635-78-5 N-({1-[2-(4-methylphenyl)-2-oxoethyl]-1H-1,2,3-triazol-4-yl}methyl)-3-(10H-phenothiazin-10-yl)propanamide 
• 1390635-89-8 {1-[2-(4-cyanophenyl)-2-oxoethyl]-1H-1,2,3-triazol-4-yl}methyl 3-(10H-phenothiazin-10-yl)propanoate 
• 1390635-88-7 {1-[2-(4-fluorophenyl)-2-oxoethyl]-1H-1,2,3-triazol-4-yl}methyl 3-(10H-phenothiazin-10-yl)propanoate 

Relevant articles and documents

Phenothiazine-based CaaX competitive inhibitors of human farnesyltransferase bearing a cysteine, methionine, serine or valine moiety as a new family of antitumoral compounds

A new family of CaaX competitive inhibitors of human farnesyltransferase based on phenothiazine and carbazole skeleton bearing a l-cysteine, l-methionine, l-serine or l-valine moiety was designed, synthesized and biologically evaluated. Phenothiazine derivatives proved to be more active than carbazole-based compounds. Phenothiazine 1b with cysteine residue was the most promising inhibitor of human farnesyltransferase in the current study.

Ultrafast electrochromic windows based on redox-chromophore modified nanostructured semiconducting and conducting films

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Electrical communication between glucose oxidase and electrodes mediated by phenothiazine-labeled poly(ethylene oxide) bonded to lysine residues on the enzyme surface

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