1698293-93-4

Basic information

• Product Name: 4-methyl-2-(1-methylethyl)-3-pyridinamine
• CAS NO: 1698293-93-4
• Molecular Weight: 150.224
• Mol File: 1698293-93-4.mol
• Article Data: 23

Chemical Properties

• Boiling Point: 267.7±35.0 °C(Predicted)
• Density: 0.992±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 4-methyl-2-(1-methylethyl)-3-pyridinamine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methyl-2-(1-methylethyl)-3-pyridinamine(1698293-93-4)
• EPA Substance Registry System: 4-methyl-2-(1-methylethyl)-3-pyridinamine(1698293-93-4)

Safety Data

• Hazardous Substances Data: 1698293-93-4(Hazardous Substances Data)

Usage

Uses

Used as reagent to prepare KRAS G12C inhibitors which are useful for treatment pancreatic, colorectal and lung cancer.

Upstream product

• 65169-38-2 2-chloro-4-methyl-3-pyridinecarbonitrile 
• 65996-02-3 2-bromo-4-methylpyridine-3-carbonitrile 
• 93271-59-1 1,2-dihydro-2-oxo-4-methylpyridine-3-carbonitrile 
• 920-39-8 isopropylmagnesium bromide 
• 126325-50-6 3-amino-2-bromo-4-methylpyridine 
• 29509-06-6 4-methyl-3-oxopentanonitrile 
• 133627-45-9 3-Amino-2-chloro-4-methylpyridine 
• 1269438-44-9 4-methyl-3-nitro-2-isopropenylpyridine 
• 23056-39-5 2-chloro-3-nitro-4-methylpyridine 
• 1068-55-9 isopropylmagnesium chloride 
• 77047-87-1 isopropyl zinc bromide 

Downstream Products

• 2252403-82-8 7-chloro-6-fluoro- 1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione 
• 2252403-56-6 (1R)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(1-methylethyl)-3-pyridinyl]-4-[(2S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]pyrido[2,3-d]pyrimidin-2(1H)-one 

Relevant articles and documents

HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF

The present disclosure relates to inhibitors of one or more isoforms of RAS, such as inhibitors of one or more of KRAS, HRAS and NRAS, or mutants thereof, such as G12D, G12V, G13D or G12C mutants thereof. Therapeutic methods of treating conditions and diseases using these inhibitors are also provided.

Synthesis method of 2-isopropyl-3-amino-4-methylpyridine

The invention discloses a synthesis method of 2-isopropyl-3-amino-4-methylpyridine, wherein the synthesis method comprises the steps: by taking ethyl isobutyrate as a raw material, sequentially carrying out condensation, aldol condensation, methylation condensation and aminopyridine cyclization to obtain AMG-2, and then carrying out hydrolysis and Hofmann degradation to obtain the 2-isopropyl-3-amino-4-methylpyridine. The method has the advantages of cheap and easily available raw materials, mild conditions, simple and safe operation, high reaction selectivity, high product yield and purity, low cost and wide application prospect.

Synthesis method of 2-isopropyl-3-amino-4-methylpyridine

The invention discloses a preparation method of 2-isopropyl-3-amino-4-methylpyridine, and the preparation method comprises the following specific steps: (1) carrying out a reaction on 3-cyano-4-methyl-2-pyridone and phosphorus oxybromide to obtain 2-bromo-3-cyano-4-methylpyridine, (2) hydrolyzing the 2-bromo-3-cyano-4-methylpyridine by using concentrated sulfuric acid, so as to obtain 2-bromo-4-methyl nicotinamide; (3) reacting the 2-bromine-4-methyl nicotinamide with a sodium hypochlorite solution under the condition of sodium hydroxide, and carrying out Hofmann rearrangement to obtain 2-bromine-3-amino-4-methylpyridine; and (4) enabling the 2-bromo-3-amino-4-methylpyridine to react with an isopropyl Grignard reagent under the action of a catalyst containing iron or nickel, so as to obtain the 2-isopropyl-3-amino-4-methylpyridine. The method disclosed by the invention is low in cost and simple to operate, and is a novel method for synthesizing the 2-isopropyl-3-amino-4-methylpyridine.