170245-15-5

Basic information

• Product Name: 3H-IMIDAZO[4,5-C]PYRIDINE
• Synonyms: 3H-IMIDAZO[4,5-C]PYRIDINE;3H-Imidazo[4,5-c]pyridine(9CI)
• CAS NO: 170245-15-5
• Molecular Formula: C6H5N3
• Molecular Weight: 119.12
• Product Categories: PYRIDINE
• Mol File: 170245-15-5.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 425.1°C at 760 mmHg
• Flash Point: 224.4°C
• Appearance: /
• Density: 1.348g/cm³
• Vapor Pressure: 4.85E-07mmHg at 25°C
• Refractive Index: 1.715
• CAS DataBase Reference: 3H-IMIDAZO[4,5-C]PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3H-IMIDAZO[4,5-C]PYRIDINE(170245-15-5)
• EPA Substance Registry System: 3H-IMIDAZO[4,5-C]PYRIDINE(170245-15-5)

Safety Data

• Safety Statements: S22:Do not inhale dust.; S24/25:Avoid contact with skin and eyes.
• Hazardous Substances Data: 170245-15-5(Hazardous Substances Data)

Usage

Description

3H-Imidazo[4,5-c]pyridine is a heterocyclic compound belonging to the Benzimidazole family, characterized by its unique chemical structure and properties. It is known for its potential role in the synthesis of bioactive compounds and its ability to form carbocyclic nucleosides.

Uses

Used in Pharmaceutical Industry:
3H-Imidazo[4,5-c]pyridine is used as a key intermediate in the synthesis of various bioactive compounds for pharmaceutical applications. Its unique structure allows it to be incorporated into drug molecules, potentially enhancing their therapeutic effects and targeting specific biological pathways.
Used in Organic Chemistry:
3H-Imidazo[4,5-c]pyridine is used as a building block in organic chemistry for the construction of carbocyclic nucleosides. These nucleosides are important components in the development of new antiviral and anticancer drugs, as they can mimic the structure of natural nucleosides and interfere with the replication and transcription processes of viruses and cancer cells.

InChI:InChI=1/C6H5N3/c1-2-7-3-6-5(1)8-4-9-6/h1-4H,(H,8,9)

Upstream product

• 2770-01-6 4-chloro-1H-imidazo[4,5-c]pyridine 
• 1681-37-4 4-amino-3-nitropyridine 
• 54-96-6 3,4-diaminopyridine 
• 1758-73-2 Aminoiminomethanesulfinic acid 
• 68-12-2 N,N-dimethyl-formamide 
• 122-51-0 orthoformic acid triethyl ester 
• 124-38-9 carbon dioxide 
• 89792-18-7 3,4-bis(formylamino)pyridine 
• 3243-24-1 imidazo<4,5-c>pyridine-4-one 
• 33631-02-6 3,4-diamino-pyridin-2-ol 
• 105952-93-0 5-aminoimidazo<4,5-c>pyridinium mesitylenesulfonate 
• 105952-94-1 5-ethoxycarbonyliminoimidazo<4,5-c>pyridinium ylide 
• 64-18-6 formic acid 
• 50-00-0 formaldehyd 

Downstream Products

• 78582-15-7 4-chloro-1-(2'-deoxy-β-D-erythro-pentofuranosyl)-1H-imidazo<4,5-c>pyridine 
• 78582-17-9 4-Amino-1-(2-deoxy-β-D-erythropentofuranosyl)-1H-imidazo<4,5-c>pyridine 
• 62002-31-7 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine dihydrochloride 
• 7465-42-1 3-β-D-Ribofuranosyl-3H-imidazo<4.5-c>pyridin 
• 91184-02-0 1H-Imidazo[4,5-c]pyridine-N-oxide 
• 7239-81-8 1H-imidazo[4,5-c]pyridine-2(3H)-thione 
• 6811-77-4 3-deazaadenine 

Relevant articles and documents

Complete Catalytic Deoxygenation of CO2 into Formamidine Derivatives

-

Methyltrioxorhenium (MeReO3) catalyzed selective oxidation of purine and related compounds into their N-oxides

A convenient method for the selective N-oxidation of purine, 6-methylpurine, 1H-imidazo[4,5-c]pyridine, 1H-imidazo[4,5-b]pyridine, 6-chloropurine, 6-bromopurine, and 7-azaindole by H2O2 catalyzed by methyltrioxorhenium is reported.

-

-

Family-wide analysis of aminoacyl-sulfamoyl-3-deazaadenosine analogues as inhibitors of aminoacyl-tRNA synthetases

Aminoacyl-tRNA synthetases (aaRSs) are enzymes that precisely attach an amino acid to its cognate tRNA. This process, which is essential for protein translation, is considered a viable target for the development of novel antimicrobial agents, provided species selective inhibitors can be identified. Aminoacyl-sulfamoyl adenosines (aaSAs) are potent orthologue specific aaRS inhibitors that demonstrate nanomolar affinities in vitro but have limited uptake. Following up on our previous work on substitution of the base moiety, we evaluated the effect of the N3-position of the adenine by synthesizing the corresponding 3-deazaadenosine analogues (aaS3DAs). A typical organism has 20 different aaRS, which can be split into two distinct structural classes. We therefore coupled six different amino acids, equally targeting the two enzyme classes, via the sulfamate bridge to 3-deazaadenosine. Upon evaluation of the inhibitory potency of the obtained analogues, a clear class bias was noticed, with loss of activity for the aaS3DA analogues targeting class II enzymes when compared to the equivalent aaSA. Evaluation of the available crystallographic structures point to the presence of a conserved water molecule which could have importance for base recognition within class II enzymes, a property that can be explored in future drug design efforts.

Highly Efficient and Catalyst-Free Synthesis of Benzimidazoles in Aqueous Media

Abstract: A convenient and highly efficient, catalysts-free synthesis of benzimidazoles in an aqueous medium has been developed. The conditions of the synthesis were optimized, and its scope was successfully extended to various substrates with good to excellent yields. The experimental procedure is simple, and the products can be isolated by filtration followed by recrystallization from water.

Method For Preparing Nitrogen Compounds

The present invention relates to a method for preparing nitrogen compounds using carbon dioxide, and to the use of the method in the production of vitamins, pharmaceutical products, adhesives, acrylic fibres, synthetic leathers, pesticides, herbicides, antifungal agents and fertilisers. The invention also relates to a method for producing vitamins, pharmaceutical products, adhesives, acrylic fibres, synthetic leathers, pesticides, herbicides, antifungal agents and fertilisers, which includes a step of preparing nitrogen compounds using the method of the invention. The invention further relates to a method for preparing labelled nitrogen compounds using carbon dioxide and to the uses thereof.