170376-11-1

Upstream product

• 4099-88-1 (3aS,6R,6aS)-6-(hydroxymethyl)-2,2-dimethyl-tetrahydrofuro[3,4-d]-[1,3]dioxol-4-ol 
• 98-88-4 benzoyl chloride 
• 87-72-9 D-lyxose 
• 14131-84-1 2,3:5,6-di-O-isopropylidene-α-D-mannofuranose 
• 36574-21-7 α-D-mannose 
• 57492-91-8 1-O-benzoyl 2,3-O-isopropylidene-α-D-lyxopentodialdehydo-1,4-furanoside 
• 57526-34-8 (+)-2,3:5,6-di-O-isopropylidene-α-D-mannofuranos-3-yl benzoate 
• 57492-90-7 1-O-benzoyl-2,3-O-isopropylidene-α-D-mannofuranoside 
• 110808-28-1 1-O-benzoyl-2,3-O-isopropylidene-α-D-lyxofuranose 
• 110808-29-2 1-O-benzoyl-2,3-O-isopropylidene-5-O-(p-tolylsulfonyl)-α-D-lyxofuranose 

Downstream Products

• 497181-36-9 (3R,5R)-3,4,5-Trihydroxy-piperidine-1-carboxylic acid benzyl ester 
• 497181-35-8 (3R,4S,5R)-1-benzyloxycarbonyl-4,5-isopropylidenedioxypiperidin-3-ol 
• 497181-52-9 (3S,5S)-1-benzyloxycarbonyl-3,5-bis(tert-butyldimethylsilyloxy)piperidine 
• 497181-37-0 (3R,5R)-1-benzyloxycarbonyl-3,5-bis(tert-butyldimethylsilyloxy)piperidin-4-ol 
• 497181-41-6 (3R,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-4-phenoxythiocarbonyloxy-piperidine-1-carboxylic acid benzyl ester 
• 497181-39-2 (3R,5R)-1-benzyloxycarbonyl-3,5-bis(tert-butyldimethylsilyloxy)-4-[3'-(tert-butyldimethylsilyloxy)propoxy]piperidine 
• 664978-86-3 (3R,5R)-1-benzyloxycarbonyl-3,5-bis(tert-butyldimethylsiloxy)-4-(1-imidazolylcarbothioyloxy)-piperidine 
• 1236033-61-6 1-O-benzoyl-5-[(N',N''-di-tert-butoxycarbonyl)guanidino]-5-deoxy-2,3-O-isopropylidene-α-D-lyxofuranose 
• 204992-81-4 (3S,4S,5R)-4,5-Bis-benzoyloxy-3-benzoyloxymethyl-3-hydroxy-piperidine-1-carboxylic acid tert-butyl ester 
• 328533-48-8 benzoyl 5-(N-benzyloxycarbonyl)amino-5-deoxy-2,3-O-isopropylidene-α-D-lyxofuranoside 

Relevant academic research and scientific papers

Synthesis of novel 1α,25-dihydroxy-19-norvitamin D3 with an amide conjugate

The diene system of 1α,25-dihydroxy-19-norvitamin D3 was replaced by a stable amide bond. A 3-hydroxypropoxy group, which was effective on enhancing binding affinity of 1α,25-dihydroxyvitamin D3 for vitamin D receptor (VDR), was introduced to the C2-position of the amide type analogue of 1α,25-dihydroxy-19-norvitamin D3. The amide analogue was found to be not suitable for binding to the ligand binding domain of the bovine thymus VDR, and additional modification at the C2-position did not improve the affinity. Potency in induction of HL-60 cell differentiation was evaluated for the novel amide analogues (3a-c).

Fragmentation of carbohydrate anomeric alkoxy radicals. Synthesis of polyhydroxy piperidines and pyrrolidines related to carbohydrates

Imino sugars of the piperidine and pyrrolidine types can be specifically obtained when protected 5-amino-5-deoxyfuranopentoses, 5-amino-5-deoxyfuranohexoses, 6-amino-6-deoxyfuranohexoses, and 6-amino-6-deoxypyranohexoses undergo a tandem alkoxy radical β-fragmentation-intramolecular cyclization reaction. The reaction is promoted by the system: iodosylbenzene - iodine under mild conditions. The tert-butoxycarbonyl, benzyloxycarbonyl, and diphenylphosphinoyl radicals have been studied as amino-protecting groups. Using this methodology, polyhydroxylated pyrrolidines of the D-erythrofuranoses 34 and 35, D-threofuranose 36, L-xylofuranose 42, and D-arabinofuranose 43 series and polyhydroxylated piperidines of the D-arabinopyranose type 37 and 38 were obtained.

1-N-Iminosugars: Potent and selective inhibitors of β-glycosidases

A series of 1-N-iminosugars were synthesized to supply the need for glycosidase inhibitors that are both highly potent and selective for β- glycosidases. Designed on the basis of the transition-state model of the β- glucosidase reaction, these iminosugar

An extremely potent inhibitor for β-galactosidase

A new galactose-type iminosugar in which a nitrogen atom is in the anomeric position was synthesized and was found to be an extremely potent inhibitor for β-galactosidase with Ki = 4 nM.