57526-34-8

Upstream product

• 98-88-4 benzoyl chloride 
• 14131-84-1 2,3:5,6-di-O-isopropylidene-α-D-mannofuranose 
• 65-85-0 benzoic acid 
• 693-13-0 diisopropyl-carbodiimide 
• 7306-64-1 2,3,5,6-di-O-isopropylidene-D-mannono-1,4-lactone 
• 36574-21-7 α-D-mannose 

Downstream Products

• 57492-90-7 1-O-benzoyl-2,3-O-isopropylidene-α-D-mannofuranoside 
• 73111-63-4 1-O-benzoyl-5,6-dideoxy-2,3-O-isopropylidene-α-D-lyxo-5-eno-furanoside 
• 57492-92-9 methyl 1-O-benzoyl-5,6,7,8-tetradeoxy-2,3-O-isopropylidene-D-lyxo-non-5,7-dienofuranuronate 
• 57492-93-0 methyl 1-O-benzoyl-5,6,7,8-tetradeoxy-2,3-O-isopropylidene-D-lyxo-nonofuranuronate 
• 664978-86-3 (3R,5R)-1-benzyloxycarbonyl-3,5-bis(tert-butyldimethylsiloxy)-4-(1-imidazolylcarbothioyloxy)-piperidine 
• 497181-39-2 (3R,5R)-1-benzyloxycarbonyl-3,5-bis(tert-butyldimethylsilyloxy)-4-[3'-(tert-butyldimethylsilyloxy)propoxy]piperidine 
• 497181-41-6 (3R,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-4-phenoxythiocarbonyloxy-piperidine-1-carboxylic acid benzyl ester 
• 497181-37-0 (3R,5R)-1-benzyloxycarbonyl-3,5-bis(tert-butyldimethylsilyloxy)piperidin-4-ol 
• 497181-52-9 (3S,5S)-1-benzyloxycarbonyl-3,5-bis(tert-butyldimethylsilyloxy)piperidine 
• 497181-35-8 (3R,4S,5R)-1-benzyloxycarbonyl-4,5-isopropylidenedioxypiperidin-3-ol 
• 497181-36-9 (3R,5R)-3,4,5-Trihydroxy-piperidine-1-carboxylic acid benzyl ester 
• 170376-11-1 5-azido-1-O-benzoyl-5-deoxy-2,3-O-isopropylidene-α-D-lyxofuranose 
• 110808-29-2 1-O-benzoyl-2,3-O-isopropylidene-5-O-(p-tolylsulfonyl)-α-D-lyxofuranose 
• 110808-28-1 1-O-benzoyl-2,3-O-isopropylidene-α-D-lyxofuranose 

Relevant academic research and scientific papers

Synthesis of novel 1α,25-dihydroxy-19-norvitamin D3 with an amide conjugate

The diene system of 1α,25-dihydroxy-19-norvitamin D3 was replaced by a stable amide bond. A 3-hydroxypropoxy group, which was effective on enhancing binding affinity of 1α,25-dihydroxyvitamin D3 for vitamin D receptor (VDR), was introduced to the C2-position of the amide type analogue of 1α,25-dihydroxy-19-norvitamin D3. The amide analogue was found to be not suitable for binding to the ligand binding domain of the bovine thymus VDR, and additional modification at the C2-position did not improve the affinity. Potency in induction of HL-60 cell differentiation was evaluated for the novel amide analogues (3a-c).

SYNTHESES OF 1-O-ACYLALDOSE DERIVATIVES via THE CORRESPONDING O-GLYCOSYLPSEUDOUREAS

A series of 1-O-acylaldose derivatives was prepared in good yield throught the reaction of 1,3-dialkyl-O-glycosylpseudoureas with carboxylic acids.