170456-82-3

Basic information

• Product Name: 4-BroMo-1-tosylpyrrolidin-3-one
• Synonyms: 4-BroMo-1-tosylpyrrolidin-3-one;4-Bromo-1-(toluene-4-sulfonyl)-pyrrolidin-3-one
• CAS NO: 170456-82-3
• Molecular Formula: C₁₁H₁₂BrNO₃S
• Molecular Weight: 318.18688
• Mol File: 170456-82-3.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 446.1±55.0 °C(Predicted)
• Appearance: /
• Density: 1.638±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -10?+-.0.40(Predicted)
• CAS DataBase Reference: 4-BroMo-1-tosylpyrrolidin-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BroMo-1-tosylpyrrolidin-3-one(170456-82-3)
• EPA Substance Registry System: 4-BroMo-1-tosylpyrrolidin-3-one(170456-82-3)

Safety Data

• Hazardous Substances Data: 170456-82-3(Hazardous Substances Data)

Usage

General Description

4-Bromo-1-tosylpyrrolidin-3-one is a chemical compound with the molecular formula C13H14BrNO3S. It is a tosylpyrrolidinone derivative, which is a class of compounds commonly used in organic synthesis and pharmaceutical research. This specific compound has a bromine atom at the 4th position of the pyrrolidin ring and a tosyl group attached to the 1st position, making it a versatile building block for the synthesis of other organic molecules. It is often used as an intermediate in the production of pharmaceuticals, agrochemicals, and other fine chemicals, and its unique structure and reactivity make it a valuable tool for chemical synthesis.

Upstream product

• 170456-84-5 4-bromo-1-(toluene-4-sulfonyl)pyrrolidin-3-ol 
• 170456-83-4 1-tosyl-3-(R)-(-)-hydroxypyrrolidine 
• 16851-72-2 1-[(4-methylphenyl)sulfonyl]-2,5-dihydro-1H-pyrrole 
• 70-55-3 toluene-4-sulfonamide 
• 73696-28-3 1-[(4-methylphenyl)sulfonyl]pyrrolidin-3-one 

Downstream Products

• 170456-89-0 2-methyl-5-(toluene-4-sulfonyl)-4,6-dihydro-5H-pyrrolo<3,4-d>thiazole 
• 1620080-90-1 C₁₇H₁₇N₃O₃S₂ 
• 1620080-91-2 2-(pyridin-2-yl)-5-tosyl-5,6-dihydro-4H-pyrrolo[3,4-d]thiazole 
• 1004764-09-3 2-[4-(3-chloropropoxy)phenyl]-5-[(4-methylphenyl)sulfonyl]-5,6-dihydro-4H-pyrrolo[3,4-d][1,3]thiazole 
• 439692-14-5 C₂₀H₂₀N₂O₃S₂ 
• 439692-13-4 C₂₀H₂₂N₂O₄S₂ 
• 1004764-08-2 2-[4-(3-chloropropoxy)phenyl]-5-[(4-methylphenyl)sulfonyl]-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d][1,3]thiazol-3a-ol 
• 170456-91-4 2-Methylamino-5-(toluene-4-sulfonyl)-4,5,6,6a-tetrahydro-pyrrolo[3,4-d]thiazol-3a-ol 
• 170456-88-9 2-methyl-5-(toluene-4-sulfonyl)-4,5,6,6a-tetrahydropyrrolo<4,3-d>thiazol-3a-ol 

Relevant articles and documents

CRYSTAL AND SALT OF NITROIMIDAZOLE, AND MANUFACTURING METHOD THEREOF

The present invention discloses a crystal form and salt of a nitroimidazole compound, and a manufacturing method thereof. The invention further comprises an application of the crystal form and salt in preparing a pharmaceutical product for preventing and treating an infection caused by Mycobacterium tuberculosis or another microbe.

Discovery of novel thieno[2,3-d]pyrimidin-4-yl hydrazone-based cyclin-dependent kinase 4 inhibitors: synthesis, biological evaluation and structure-activity relationships

The design, synthesis, and evaluation of novel thieno[2,3-d]pyrimidin-4-yl hydrazone analogues as cyclin-dependent kinase 4 (CDK4) inhibitors are described. In continuing our program aim to search for potent CDK4 inhibitors, the introduction of a thiazole group at the hydrazone part has led to marked enhancement of chemical stability. Furthermore, by focusing on the optimization at the C-4′ position of the thiazole ring and the C-6 position of the thieno[2,3-d]pyrimidine moiety, compound 35 has been identified with efficacy in a xenograft model of HCT116 cells. In this paper, the potency, selectivity profile, and structure-activity relationships of our synthetic compounds are discussed.

FUSED OXAZOLES and THIAZOLES AS HISTAMINE H3- RECEPTOR LIGANDS

The present invention relates to compounds comprising fused oxazole or thiazole derivatives of formula (I), processes for preparing them, pharmaceutical compositions comprising said compounds and their uses as H3-receptor ligands, wherein A is a cyclic amine which is linked to the propylene group via an amino nitrogen; B is selected from the group consisting of heteroaryl, 5-8-membered heterocycloalkyl, 5-8-membered cycloalkyl; X is either N or CH; Y is either O or S.