170456-82-3

Usage

Uses

Used in Pharmaceutical Research:
4-Bromo-1-tosylpyrrolidin-3-one is used as a versatile building block for the synthesis of pharmaceuticals due to its unique structure and reactivity. It serves as an intermediate in the production of various drugs, contributing to the development of new therapeutic agents.
Used in Agrochemical Production:
4-Bromo-1-tosylpyrrolidin-3-one is used as an intermediate in the production of agrochemicals, such as pesticides and herbicides. Its unique properties allow for the creation of effective and targeted agricultural products.
Used in Organic Synthesis:
4-Bromo-1-tosylpyrrolidin-3-one is used as a valuable tool in organic synthesis for the creation of other organic molecules. Its reactivity and structural features make it suitable for various chemical reactions, leading to the formation of a wide range of compounds.
Used in Fine Chemicals Production:
4-Bromo-1-tosylpyrrolidin-3-one is used as an intermediate in the production of fine chemicals, which are high-purity chemicals used in various industries, including pharmaceuticals, fragrances, and flavors. Its unique structure and reactivity contribute to the synthesis of high-quality fine chemicals.

Upstream product

• 70-55-3 toluene-4-sulfonamide 
• 170456-84-5 4-bromo-1-(toluene-4-sulfonyl)pyrrolidin-3-ol 
• 170456-83-4 1-tosyl-3-(R)-(-)-hydroxypyrrolidine 
• 16851-72-2 1-[(4-methylphenyl)sulfonyl]-2,5-dihydro-1H-pyrrole 
• 73696-28-3 1-[(4-methylphenyl)sulfonyl]pyrrolidin-3-one 

Downstream Products

• 170456-88-9 2-methyl-5-(toluene-4-sulfonyl)-4,5,6,6a-tetrahydropyrrolo<4,3-d>thiazol-3a-ol 
• 170456-89-0 2-methyl-5-(toluene-4-sulfonyl)-4,6-dihydro-5H-pyrrolo<3,4-d>thiazole 
• 439692-14-5 C₂₀H₂₀N₂O₃S₂ 
• 1620080-90-1 C₁₇H₁₇N₃O₃S₂ 
• 1620080-91-2 2-(pyridin-2-yl)-5-tosyl-5,6-dihydro-4H-pyrrolo[3,4-d]thiazole 
• 1004764-09-3 2-[4-(3-chloropropoxy)phenyl]-5-[(4-methylphenyl)sulfonyl]-5,6-dihydro-4H-pyrrolo[3,4-d][1,3]thiazole 
• 439692-13-4 C₂₀H₂₂N₂O₄S₂ 
• 1004764-08-2 2-[4-(3-chloropropoxy)phenyl]-5-[(4-methylphenyl)sulfonyl]-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d][1,3]thiazol-3a-ol 
• 170456-91-4 2-Methylamino-5-(toluene-4-sulfonyl)-4,5,6,6a-tetrahydro-pyrrolo[3,4-d]thiazol-3a-ol 

Relevant academic research and scientific papers

CRYSTAL AND SALT OF NITROIMIDAZOLE, AND MANUFACTURING METHOD THEREOF

The present invention discloses a crystal form and salt of a nitroimidazole compound, and a manufacturing method thereof. The invention further comprises an application of the crystal form and salt in preparing a pharmaceutical product for preventing and treating an infection caused by Mycobacterium tuberculosis or another microbe.

ANTI-PULMONARY TUBERCULOSIS NITROIMIDAZOLE DERIVATIVE

Disclosed is a substituted nitroimidazole derivative, which is mainly used for treating related diseases caused by mycobacterial infections, such as Mycobacterium tuberculosis, especially being suitable for diseases caused by resistant Mycobacterium tuberculosis.

Discovery of novel thieno[2,3-d]pyrimidin-4-yl hydrazone-based cyclin-dependent kinase 4 inhibitors: synthesis, biological evaluation and structure-activity relationships

The design, synthesis, and evaluation of novel thieno[2,3-d]pyrimidin-4-yl hydrazone analogues as cyclin-dependent kinase 4 (CDK4) inhibitors are described. In continuing our program aim to search for potent CDK4 inhibitors, the introduction of a thiazole group at the hydrazone part has led to marked enhancement of chemical stability. Furthermore, by focusing on the optimization at the C-4′ position of the thiazole ring and the C-6 position of the thieno[2,3-d]pyrimidine moiety, compound 35 has been identified with efficacy in a xenograft model of HCT116 cells. In this paper, the potency, selectivity profile, and structure-activity relationships of our synthetic compounds are discussed.

FUSED OXAZOLES and THIAZOLES AS HISTAMINE H3- RECEPTOR LIGANDS

The present invention relates to compounds comprising fused oxazole or thiazole derivatives of formula (I), processes for preparing them, pharmaceutical compositions comprising said compounds and their uses as H3-receptor ligands, wherein A is a cyclic amine which is linked to the propylene group via an amino nitrogen; B is selected from the group consisting of heteroaryl, 5-8-membered heterocycloalkyl, 5-8-membered cycloalkyl; X is either N or CH; Y is either O or S.

SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF 1-CYCLOPROPYL-6,8-DIFLUORO-7-(2-SUBSTITUTED 4,6-DIHYDRO-1H-PYRROLOTHIAZOL-5-YL)-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACID

Quinolone derivatives (9 and 10) substituted with bicyclothiazole (7) and (8) at C-7 position were synthesized.Bicyclothiazole derivatives (7 and 8) were prepared through 9 steps by way of the 4-bromo-3-oxopyrrolidine (16) was a key intermediate and intro