170456-83-4

Usage

Uses

Used in Organic Synthesis:
1-Tosyl-3-pyrrolidinol is used as a synthetic intermediate for the production of a wide range of organic compounds. Its application in this field is due to its ability to facilitate the formation of complex molecules through various chemical reactions, making it a versatile building block in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
1-Tosyl-3-pyrrolidinol is used as a key component in the development of new pharmaceuticals. Its role in this industry is attributed to its potential to be incorporated into the molecular structure of various drugs, thereby contributing to their therapeutic properties and effectiveness in treating different medical conditions.
Used in Agrochemical Industry:
In the agrochemical sector, 1-Tosyl-3-pyrrolidinol is used as a vital ingredient in the synthesis of novel agrochemicals. Its application in this industry is driven by its potential to enhance the performance of pesticides, herbicides, and other agricultural chemicals, ultimately leading to improved crop protection and yield.
Used in Specialty Chemicals:
1-Tosyl-3-pyrrolidinol is also employed in the production of specialty chemicals, which are tailored to meet the specific requirements of various industries. Its use in this area is due to its ability to impart unique properties to the final products, such as improved stability, reactivity, or selectivity, depending on the desired application.

InChI:InChI=1/C11H15NO3S/c1-9-2-4-11(5-3-9)16(14,15)12-7-6-10(13)8-12/h2-5,10,13H,6-8H2,1H3

Upstream product

• 775-15-5 1-benzyl-3-pyrrolidinol 
• 98-59-9 p-toluenesulfonyl chloride 
• 40499-83-0 pyrrolidin-3-ol 
• 70775-39-2 dimethylsulfoxonium methylide 
• 718633-51-3 N-1-(3-oxopropyl)-4-methyl-1-benzenesulfonamide 
• 10285-80-0 N-tosyl-3-butenylamine 
• 141-78-6 ethyl acetate 
• 5997-56-8 4-methyl-N-(oxiran-2-ylmethyl)benzenesulfonamide 
• 1774-47-6 trimethylsulfoxonium iodide 
• 111810-68-5 3-hydroxypyrrolidine hydrochloride 
• 16851-72-2 1-[(4-methylphenyl)sulfonyl]-2,5-dihydro-1H-pyrrole 
• 70-55-3 toluene-4-sulfonamide 
• 170456-84-5 4-bromo-1-(toluene-4-sulfonyl)pyrrolidin-3-ol 

Downstream Products

• 131912-34-0 1-tosylpyrrolidin-3-yl 4-methylbenzenesulfonate 
• 170456-85-6 2-(N-t-butoxycarbonylmethylamino)-5-(toluene-4-sulfonyl)-4,5,6,6a-tetrahydropyrrolo<3,4-d>thiazol-3a-ol 
• 170456-86-7 2-(N-t-butoxycarbonylmethylamino)-5-(toluene-4-sulfonyl)-4,6-dihydro-5H-pyrrolo<3,4-d>thiazole 
• 170456-91-4 2-Methylamino-5-(toluene-4-sulfonyl)-4,5,6,6a-tetrahydro-pyrrolo[3,4-d]thiazol-3a-ol 
• 170456-88-9 2-methyl-5-(toluene-4-sulfonyl)-4,5,6,6a-tetrahydropyrrolo<4,3-d>thiazol-3a-ol 
• 170456-89-0 2-methyl-5-(toluene-4-sulfonyl)-4,6-dihydro-5H-pyrrolo<3,4-d>thiazole 
• 170456-82-3 4-bromo-1-(p-toluenesulfonyl)pyrrolidin-3-one 
• 73696-28-3 1-[(4-methylphenyl)sulfonyl]pyrrolidin-3-one 

Relevant academic research and scientific papers

Proline-catalyzed sequential syn-Mannich and [4 + 1]-annulation cascade reactions to form densely functionalized pyrrolidines

A highly efficient one-pot [4 + 1]-annulation process for the asymmetric synthesis of densely functionalized pyrrolidine derivatives is described. The in situ generated syn-Mannich adduct obtained via proline catalysis acts as a four-atom component, and Corey's sulfur ylide or ethyl bromoacetate acts as a one-atom carbon source to construct pyrrolidine units in a highly enantio- and diastereoselective manner.

Copper-Catalyzed Cross-Coupling between Alkyl (Pseudo)halides and Bicyclopentyl Grignard Reagents

The development of a copper-catalyzed cross-coupling between primary and secondary (pseudo)halides and bicyclopentyl Grignard reagents is reported. Highly strained bicyclopentanes can be cross-coupled with a large panel of primary alkyl mesylates and secondary alkyl iodides. The catalytic system is simple and cheap, and the reaction is general and chemoselective.

A visible-light photoinduced charge-transfer complex promoted the ring opening of: N-alkyl-4-piperidinols

A visible-light photoinduced ring opening of N-alkyl-4-piperidinols under mild conditions has been achieved. The reaction sequence involves a visible-light-induced charge-transfer complex, which promoted the S-Cl bond cleavage of sulfonyl chlorides. The generated sulfonyl radical further reacts with N-alkyl-4-piperidinol cation radicals to achieve C-N and C-C bond cleavages to yield homoallylamine products.

New IDO-1 INHIBITOR AND USE THEREOF

The present invention refers to inhibit iDO-a 1 number and their use relates to search, more particularly by inhibiting the activity of the intracellular enzyme IDO (indoleamine-a 2,3 a-dioxygenase), which show excellent iDO-a 1 billion number number inhi

Boron trifluoride etherate functioning as a fluorine source in an iodosobenzene-mediated intramolecular aminofluorination of homoallylic amines

A widely used Lewis acid BF3·Et2O was shown to be capable of acting as an efficient fluorinating agent in an intramolecular aminofluorination reaction of homoallylic amines to provide 3-fluoropyrrolidines mediated by a commercially available hypervalent iodine(III) reagent PhIO at room temperature. A mechanism involving a carbocation intermediate was proposed on the basis of several experimental evidence.

A smooth rearrangement of N-p-toluenesulfonyl 2-tert- butyldiphenylsilylmethyl-substituted azetidines into N-p-toluenesulfonyl 3-tert-butyldiphenylsilyl-substituted pyrrolidines

The rearrangement of N-p-toluenesulfonyl 2-tert-butyldiphenylsilylmethyl- substituted azetidines into 3-tert-butyldiphenylsilyl-substituted pyrrolidines under Lewis acid conditions in dichloromethane involves 1,2-migration of silicon through a siliranium ion. The formation of siliranium ion was discovered not to be in concert with σC-N cleavage from stereochemical analysis of the pyrrolidine products formed from 3- and 4-substituted-2-tert- butyldiphenylsilylmethyl azetidines and also from the optical rotation data and chiral HPLC analysis of the pyrrolidine product formed from N-p-toluenesulfonyl 2(R)-tert-butyldiphenylsilylmethyl azetidine. The formation of sterically less hindered siliranium ion is followed by its SN2 opening by the internal nitrogen nucleophile. Oxidative cleavage of σC-Si bond leads to the formation of 3-hydroxypyrrolidines.

3-Hydroxypyrrolidines from epoxysulfonamides and dimethylsulfoxonium methylide

N-Tosyl-protected 3-hydroxypyrrolidines are prepared by reaction of dimethylsulfoxonium methylide with readily available epoxysulfonamides. The Royal Society of Chemistry 2006.

N-Substituted-3-arylpyrrolidines: Potent and Selective Ligands at Serotonin 1A Receptor

3-Arylpyrrolidines are synthesized through the coupling of N-benzyl-3-(methanesulfonyloxy)pyrrolidine with diarylcuprates. Pharmacological evaluation of a series of N-substituted-3-arylpyrrolidines toward several neurotransmitter receptors indicated that some of them are good ligands for serotonin 1A receptor. Particularly, N-pyrrolidines were found to be potent and selective ligands. A preliminary biological evaluation for several selected compounds indicated that they are potentially effective antianxiety and antidepressant agents.

SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF 1-CYCLOPROPYL-6,8-DIFLUORO-7-(2-SUBSTITUTED 4,6-DIHYDRO-1H-PYRROLOTHIAZOL-5-YL)-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACID

Quinolone derivatives (9 and 10) substituted with bicyclothiazole (7) and (8) at C-7 position were synthesized.Bicyclothiazole derivatives (7 and 8) were prepared through 9 steps by way of the 4-bromo-3-oxopyrrolidine (16) was a key intermediate and intro